November 22, 2009


Theodore L. DeWeese, M.D.

Chairman, Department of Radiation Oncology and Molecular Radiation Science
Johns Hopkins Medical Institutions

Professor, Department of Oncology & Urology

Email:deweete@jhmi.edu

    Free Access to abstracts at PubMed
Articles Published in Professional Journals
ARTICLES PUBLISHED IN PROFESSIONAL JOURNALS
  1. DeWeese, T.L. Hazuka, M.B., Hommel, D.J., Kinzie, J.J., Daniels, W.E. AIDS-related non-Hodgkin's Lymphoma: The Outcome and Efficacy of Radiation Therapy. Int J Radiat Oncol Biol Phys 20:803-808, 1991.

     

  2. Carducci, M.A., DeWeese, T.L. Nelson, W.G., Simons, J.W., Sinibaldi, V., Eisenberger, M.A. Prostate Cancer Treatment Strategies Based on Tumor-Specific Biological Principles: Future Directions. Semin Oncol 23:56-62, 1996.

     

  3. DeWeese, T.L. , Walsh, J.C., Dillehay, L.E., Kessis, T.D., Hedrick, L., Cho, K.R., Nelson, W.G. Human Papillomavirus E6 and E7 Oncoproteins Alter Cell Cycle Progression But Not Radiosensitivity of Carcinoma Cells Treated with Low Dose-Rate Radiation. Int J Radiat Oncol Biol Phys 37:145-154 1997.

  4. Cadeddu J.A., Partin, A.W., DeWeese, T.L, Walsh, P.C. Long-term Results of Radiation Therapy For Prostate Cancer Recurrence Following Radical Prostatectomy. J Urol 159:173-178, 1998.

     

  5. DeWeese, T.L. , Shipman, J.M., Dillehay, L.E., Nelson, W.G. Sensitivity of Human Prostatic Carcinoma Cell Lines to Low Dose Rate Radiation Exposure. J Urol 159:591-598, 1998.

     

  6. Wurzler, K.K., DeWeese, T.L. , Sebald, W., Reddi, A.H. Radiation-induced Impairment of Bone Healing can be Overcome by Recombinant Human Bone Morphogenetic Protein-2. J Craniofacial Surg 9:131-137, 1998.

     

  7. Polascik, T., Pound, C.R., DeWeese, T.L. , Walsh, P.C. Comparison of Radical Prostatectomy and 125I Interstitial Radiotherapy for the Treatment of Clinically Localized Prostate Cancer: A 7-year Biochemical (PSA) Progression Analysis. Urology 51:884-889, 1998.

     

  8. Healy, C.G., Simons, J.W., Carducci, M.A., DeWeese, T.L. , Bartkowski, M., Tong, K.P., Bolton, W.E. Impaired Expression And Function Of Signal Transducing Zeta Chains In Peripheral T Cells And Natural Killer Cells In Patients With Prostate Cancer. Cytometry 32:109-119, 1998.

     

  9. DeWeese, T.L. , Shipman, J.M., Larrier, N.A., Buckley N.M., Kidd, L.R., Groopman, J.D., Cutler, R.G., Riele, H, Nelson W.G. Mouse Embryonic Stem Cells Carrying One or Two Defective Msh2 Alleles Respond Abnormally to Oxidative Stress Inflicted by Low Level Radiation. Proc Natl Acad Sci USA 95:11915-11920, 1998.

     

  10. Carducci, M.A., DeWeese, T.L. , Nelson, J.B. PSA and Other Markers of Therapeutic Response. Urol Clin North Am 26:291-302, 1999.

     

  11. Welsh, J., Torre, T.G., DeWeese, T.L. , O'Reilly, S. Radiation Myositis. Ann Oncol 10:1105-1108, 1999.

     

  12. Hurwitz, M.D., DeWeese, T.L. , Zinreich, E., Epstein, J.I., Partin, A.P. Nuclear Morphometry Predicts Disease-free Interval for Clinically Localized Adenocarcinoma of the Prostate Treated with Definitive Radiation Therapy. Int J Cancer 84:594-597, 1999.

     

  13. DeWeese, T.L. , Song, Dan Y. Current Evidence for the Role of Combined Androgen Suppression and Radiation in the Treatment of Adenocarcinoma of the Prostate. Urology 55:169-174, 2000.

     

  14. Chan, DY, Koniaris, LG, Magee, C., Ferrell, M., Solomon, S., Lee, BR., Anderson, JH., Smith, DO., Czapski, J., DeWeese, T., Choti, A., Kavoussi, LR. Feasibility of Ablating Normal Renal Parenchyma By Interstitial Photon Radiation Energy In a Canine Model. J Endourol 14:111-116, 2000.

     

  15. Koniaris, L.G., Chan, D.Y., Magee, C., Solomon, S.B., Anderson, J.H., Smith, D.O., DeWeese, T.L. , Kavoussi, L.R., Choti, M.A. Focal Hepatic Ablation Using Interstitial Photon Radiation Energy in a Canine Model. J Am Coll Surg 191:164-174, 2000.

     

  16. Thurman, S.A., DeWeese, T.L. Multimodality Therapy for the Treatment of Muscle-Invasive Bladder Cancer. Semin Urol Oncol 18:313-322, 2000.

     

  17. Li, S., DeWeese, T.L. , Lee, D.J., Kleinberg, L., Wharam, M. A Dose Texture Plot in a Moving Frame as a New Planning Tool for Single-Plane Implants in HDR Brachytherapy. Med Phys 28: 97-103, 2001.

     

  18. Solomon, S.B., Koniaris, L.G., Chan, D.Y., Magee, C.A., DeWeese, T.L. , Kavoussi, L.R., Choti, M.A. Temporal CT Changes after Hepatic and Renal Interstitial Radiotherapy in a Canine Model. JCAT 25: 74-80, 2001.

     

  19. DeWeese, T.L. , Hruszkewycz, A.M., Marnett, L.J. Oxidative Stress in Chemoprevention Trials. Urology 57: 137-140, 2001.

     

  20. Nelson, W.G., DeMarzo, A.M., DeWeese, T.L. The Molecular Pathogenesis of Prostate Cancer: Implications for Prostate Cancer Prevention. Urology 57: 39-45, 2001.

     

  21. NCI Radiation Research Program Meeting Report. Young Investigators Workshop - Radiation Research Program, Radiation Oncology Sciences Program, National Cancer Institute, NIH, August 1-2, 2000. Int J. Radiation Oncology Biol Phys 49: 1505-16, 2001.

     

  22. Nelson, W.G., DeMarzo, A.M., DeWeese, T.L. The Molecular Pathogenesis of Prostate Cancer: Focus on the Earliest Steps. Eur Urol 39 (Suppl 4): 8-11, 2001.

     

  23. Walsh, P.C., DeWeese, T.L. , Eisenberger, M.A. A Structured Debate: Immediate Versus Deferred Androgen Suppression In Prostate Cancer - Evidence For Deferred Treatment. J Urol, 166: 508-16, 2001.

     

  24. Chen, Y., DeWeese, T., Dilley, J., Zhang, Y., Li, Y., Ramesh, N., Lee, J., Pennathur-Das, R., Radzyminski, J., Wypch, J., Brignetti, D., Scott, S., Stephens, J., Karpf, D., Henderson, D., and Yu, D-C. CV706, a Prostate Cancer-specific Adenovirus Variant, in Combination with Radiotherapy Produces Synergistic Antitumor Efficacy without Increasing Toxicity. Cancer Res 61: 5453-5460, 2001.

  25. Song, D.Y., Lawrie, W.T., Abrams, R.A., Kafonek, D.R., Bayless, M.B., Welsh, J.S., Boitnott, J.K., DeWeese, T.L. Acute and Late Radiotherapy Toxicity in Patients with Inflammatory Bowel Disease. Int J Radiat Oncol Biol Phys, 51: 455-459, 2001.

     

  26. DeWeese, T.L. , van der Poel, H., Li, S., Mikhak, B, Drew, R., Goemann, M., Hamper, U., DeJong, R., Detorie, N., Rodriguez, R., Haulk, T., DeMarzo, A.M., Piantadosi, S., Yu, D.C., Chen, Y., Henderson, D.R., Carducci, M.A., Nelson, W.G., and Simons, J.W. A Phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally-recurrent prostate cancer following radiation therapy. Cancer Res, 61:7464-72, 2001.

     

  27. Lin, X., Tascilar, M., Lee, W.-H., Lee, Vles, W.J., Lee, B.H., Veeraswamy, R., Asgari, K., Freije, D., van Rees, B., Gage, W.R., Bova, G.S., Isaacs, W.B., Brooks, J.D., DeWeese, T.L. , De Marzo, A.M., and Nelson, W.G. GSTP1 CpG Island Hypermethylation Is Responsible for the Absence of GSTP1 Expression in Human Prostate Cancer Cells. Am J Pathol, 159:1815-26, 2001.

     

  28. Lin, X., Asgari, K., Putzi, M.J., Gage, W.R., Yu, X., Cornblatt, B.S., Kumar, A., Piantadosi, S., DeWeese, T.L. , DeMarzo, A.M., and Nelson, W.G. Reversal of GSTP1 CpG Island Hypermethylation and Reactivation of ?-Class Gluthatione S-Transferase (GSTP1) Expression in Human Prostate Cancer Cells by Treatment with Procainamide. Cancer Res, 61: 8611-16, 2001.

     

  29. Nelson, W.G., DeMarzo, A.M., DeWeese, T.L. , Lin, X., Brooks, J.D., Putzi, M.J., Nelson, C.P., Groopman, J.D., and Kensler, T.W. Preneoplastic prostate lesions: an opportunity for prostate cancer prevention. Ann N Y Acad Sci 952: 135.44, 2001.

     

  30. Fichtinger, G., DeWeese, T.L. , Patriciu, A., Tanacs, A., Mazilu, D., Anderson, J.H., Masamune, K., Taylor, R.H., and Stoianovici, D. System For Robotically Assisted Prostate Biopsy and Therapy with Intra-Operative CT guidance (Preliminary Investigation). J. of Academic Radiology, 9 (1): 60-74, 2002.

     

  31. Basari, S., Lieb, J., Tang, A.M, DeWeese, T., Carducci, M., Eisenberger, M.A., Dobs, A. Long-Term Effects of Androgen Deprivation Therapy in Prostate Cancer Patients. Clin Endocrinol 56: 779-86, 2002.

     

  32. Song. D.Y., Thompson, T.L., Ramakrishnan, V., Harrison, R., Bhavsar, N., Onaodowan, O., and DeWeese, T.L. Salvage Radiotherapy for Rising or Persistent PSA Following Radical Prostatectomy. Urology, 60 (2): 281-7, 2002.

     

  33. Nelson, W.G., DeWeese, T.L. , and DeMarzo, A.M. The diet, prostate inflammation, and the development of prostate cancer. Cancer Metastasis Rev, 21:3-16, 2002.

     

  34. Parker, A.R., O’Meally, R.N., Oliver, D.H., Hua, L., Nelson, W.G., DeWeese, T.L. and Eshleman, J.R. 8-Hydroxyguanosine Repair is Defective in Some Microsatellite Stable Colorectal Cancer Cells. Cancer Res, 62:7230-7233, 2002.

     

  35. Heath, E.I., DeWeese, T.L. , Partin, A.W., DeMarzo, A.M., Groopman, J.D., Nelson, W.G., Piantadosi, S.A., Lieberman, R., and Carducci, M.A. The Design of a Randomized, Placebo-Controlled Trial of Celecoxib in Pre-Prostatectomy Men with Clinically Localized Adenocarcinoma of the Prostate. Clin Prostate Cancer, 1: 182-187, 2002.

     

  36. Li, S., Simons, J., Detorie, N., O’Rourke, B. Hamper, U., and DeWeese, T.L. Dosimetric and Technical Considerations for Interstitial Adenoviral Therapy as applied to Prostate Cancer. Int J Radiat Oncol Biol Phys, 55: 204-214, 2003.

     

  37. Collis, S.J., Ketner, G.W., Hicks, J.L., Nelson, W.G., DeMarzo, A.M., and DeWeese, T.L. Expression of DNA-PK binding protein E4-34K fails to confer radiation sensitivity to mammalian cells. Int J Radiat Biol, 79: 53-60, 2003.

     

  38. Collis, S.J., Swartz, M.J., Nelson, W.G., and DeWeese, T.L. Enhanced Radiation and Chemotherapy-Mediated Cell Killing of Human Cancer Cells by Small Inhibitory RNA Silencing of DNA Repair Factors. Cancer Res, 63: 1550-1554, 2003.

     

  39. Li, S., Frassica, D., DeWeese, T.L. , Lee, D-J., Geng, J., and Nag, S. A real-time image-guided intraoperative high-dose-rate brachytherapy system. Brachytherapy, 2: 5-16, 2003.

     

  40. DeWeese, T.L. , and Nelson, W.G. Inadequate “caretaker” gene function and human cancer development. Methods Mol Biol 222: 249-268, 2003.

     

  41. Collis, S.J., Khater, K., and DeWeese, T.L. Novel Therapeutic Strategies in Prostate Cancer Management Using Gene Therapy in Combination with Radiation Therapy. World J Urol, 21: 275-289, 2003.

     

  42. Hughes, M.A., Wang, A., and DeWeese, T.L. Two Secondary Malignancies Following Radiation Therapy for Seminoma: Case Report and Review of the Literature. Urology, 62: 748, 2003.

     

  43. Parker, A.R., O’Meally, R.N., Sahin, F., Su, G.H., Racke, F.K., Nelson, W.G., DeWeese, T.L. , and Eshleman, J.R. Defective Human MutY Phosphorylation Exists in Colorectal Cancer Cell Lines With Wild-Type MutY Alleles. J Biol Chem, 278: 47937-47945, 2003.

     

  44. DeMarzo, A.M., DeWeese, T.L. , Platz, E.A., Meeker, A.K., Nakayama, M., Epstein, J.I., Isaacs W.B., Nelson, W.G. Pathological and Molecular Mechanisms of Prostate Carcinogenesis: Implications for Diagnosis, Detection, Prevention, and Treatment. J Cell Biochem, 91: 459-477, 2004.

     

  45. Lapidus, R.G., Dang, W. Rosen, D.M., Gady, A.M., Zabelinka, Y., O’Meally, R., DeWeese, T.L. , and Denmeade, S.R. Anti-Tumor Effect of Combination Therapy with Intratumoral Controlled-Release Paclitaxel (PACLIMER(R) Microspheres) and Radiation. Prostate 58: 291-298, 2004.

     

  46. Collis, S.J. and DeWeese, T.L. Enhanced Radiation Response Through Directed Molecular Targeting Approaches. Cancer Metastasis Rev, 23: 277-292, 2004.

     

  47. Collis, S.J., Neutzel, S., Thompson, T.L., Swartz, M.J., Dillehay, L.E., Collector, M.I., Sharkis, S.J., DeWeese, T.L. Hematopoietic Progenitor Stem Cell Homing in Mice Lethally Irradiated with Differing Dose Rates of Ionizing Radiation. Radiation Res, 162: 48-55, 2004.

     

  48. DeWeese, T.L. Radiation Therapy and Androgen Suppression as Treatment for Clinically Localized Prostate Cancer: The New Standard? JAMA 292: 864-866, 2004.

     

  49. Collis, S.J., Schwaninger, J.M., Ntambi, A.J., Keller, T.W., Nelson, W.G., Dillehay, L.E., and DeWeese, T.L. Evasion of early cellular response mechanisms following low level radiation-induced DNA damage. J Biol Chem, 279: 49624-32, 2004.

     

  50. Nelson, W.G., DeMarzo, A.M., DeWeese, T.L. and Isaacs, W.B. The Role of Inflammation in the Pathogenesis of Prostate Cancer. J Urol, 172: S6-11; discussion S11-2, 2004.

     

  51. DeWeese, T.L. Making the right choices for radiation therapy. Johns Hopkins Med Lett Health After 50 16: 6, 2004.

  52. Collis, S.J., DeWeese, T.L. , Jeggo, P.A., and Parker, A.R. The Life and Death of DNA-PK”, Oncogene, 2004 Dec 13.

     

  53. Rosenbaum, E., Zahurak, M., Sinibaldi, V., Carducci, M.A., Pili, R., Laufer, M., DeWeese, T.L. , and Eisenberger, M.A. Marimastat in the treatment of patients with biochemically relapsed prostate cancer: a prospective randomized, double-blind, phase I/II trial. Clin Cancer Res, 11(12): 4437-43, 2005.

     

  54. Ouyang, X., DeWeese, T.L. , Nelson, W.G., and Abate-Shen, C. Loss-of-Function of Nkx3.1 Promotes Increased Oxidative Damage in Prostate Carcinogenesis. Cancer Res 65: 6773-9, 2005.

     

  55. DeWeese, T.L. , Song, D.Y. Radiation dose escalation as treatment for clinically localized prostate cancer: is more really better? JAMA 294(10): 1274-6, 2005.


Articles Published in Professional Journals
PUBLISHED ABSTRACTS
  1. DeWeese, T.L. , Hazuka, M.B., Hommel, D.J., Kinzie, J.J., Daniel, W.E. Aids-related Non-Hodgkin Lymphoma: Outcome and Efficacy of Radiation Therapy. Radiology, 173:218, 1989.

     

  2. DeWeese, T.L. , Wharam, M.D., Herman, M.G., Lam, W.C., Nauta, H.J., Duhon, M.A. A non-invasive Method of Fractionated Stereotactic Radiotherapy of Intracranial Tumors. Int J Rad Oncol Biol Phys 24:290, 1992.

     

  3. DeWeese, T.L. , Dillehay, L.E., Shao, Y., Williams, J.R. Low Dose-Rate Sensitization of Human Prostate Cancer Cells. Int J Rad Oncol Biol Phys. 30:319, 1994.

     

  4. DeWeese, T.L. , Walsh, J., Dillehay, L.E., Shao, Y., Kessis, T.D., Cho, K.R., Nelson, W. Acute Dose and Low Dose-Rate Irradiation of Carcinoma Cells Expressing Human Papillomavirus E6 and E7 Oncoproteins - The Significance of p53, Rb and G1 Arrest Status. Int J Radiat Oncol Biol Phys, 32:220, 1995.

     

  5. Tong, K.P., DeWeese, T.L. , Mansfield, E.P., Carducci, M.A. New Insights into Phenylbutyrate Bioactivity in Human Prostate Cancer. Proc Am Assoc Cancer Res, 37:361, 1996.

     

  6. Hurwitz, M.D., DeWeese, T.L. , Zinreich, E. , Epstein, J.I., Partin, A.P. Evaluation of a Nuclear Morphometric Parameter as a Predictor of Outcome in Patients Receiving Radiation Therapy for Prostate Cancer. Radiology, 201:342, 1996.

     

  7. DeWeese, T.L. , Bucci, J.M., Dillehay, L.E., Nelson, W.G. The Significance of p53 and G1 Cell Cycle Arrest on the Low Dose Rate Radiation Sensitivity of Human Prostate Cancer Cell Lines. 7th Prouts Neck Meeting on Prostate Cancer. 1996

     

  8. DeWeese, T.L. , Bucci, J.M., Dillehay, L.E., Nelson, W.G. Low Dose Rate Radiation Sensitivity of Human Prostate Cancer Cell Lines: The Role of p53 and G1 Cell Cycle Arrest. Proc Am Assoc Cancer Res, 38:540, 1997.

     

  9. Ravi, R., DeWeese, T.L. , McMahon, M., Zang, Y., Williams, J.R., Nelkin, B.D., Mabry, M. Activated Raf-1 Induces p21 Mediated Cell Cycle Arrest In LNCap Prostate Cancer Cells. Proc Am Assoc Cancer Res, 38:621, 1997.

     

  10. Healy, C.G., Simons, J.W., Carducci, M.A., Bartkowski, L.M., Tong, K.P., DeWeese, T.L. , and Bolton, W.E. Flow cytometric detection of decreased TCR ? expression in patients with prostate cancer. Proc Am Assoc Cancer Res 38:631, 1997.

     

  11. Walsh, P.C., Cadeddu, J.A., Partin, A.W., DeWeese, T.L. Long-term results of radiation therapy for isolated PSA elevations following radical prostatectomy. J Urol, 157:94, 1997.

  12. Carducci, M.A., DeWeese, T.L. , Marshall, F.F, Tong, K.P, Bartkowski, L.M., Simons J.W., Bolton, W.E., Healy C.G. Significant Alteration in TCR ? Expression In Circulating T-cells From Prostate Cancer Patients: A Marker For Use In Immunologic Staging. J Urol, 157:115, 1997.

     

  13. DeWeese, T.L. , Bucci, J.M., Larrier, N.A., Cutler, R.G., Riele, H., Nelson, W.G. Alteration of Cellular Radiation Response as a Consequence of Defective Mismatch Repair. Int J Rad Oncol Biol Phy, 39:252, 1997.

     

  14. Tong, K.P., David-Beabes, G., Meeker, A., Bucci, J., DeWeese, T.L. , Carducci, M.A. Phenylbulyrate (PB) has Pleiotropic Effects on Gene Transcription and Inhibits Telomerase Activity in Human Prostate Cancer. Anticancer Res, 17: 3953, 1997.

     

  15. DeWeese, T.L. , Shipman, J.M., Buckley, N.M., Thomas, R. and Nelson, W.G. Inactivation of GSTPI Genes Provides a Survival Advantage Following Oxidative DNA Damage in Human Prostate Cancer Cells. Proc Am Assoc Cancer Res, 39:466, 1998.

     

  16. Chin, B.B., Welsh, J., DeWeese, T.L. , Partin, A., Petronis, J. In-111 Prostascint Scintigraphy may Alter Therapeutic Management in Patients with Rising PSA Values after Radical Prostatectomy. J Nucl Med, 39:149, 1998.

     

  17. Ramakrishna, N,.R., Rioseco-Camacho, N., Sawyers, C.L., Yu, C.De., Henderson, D., Simons, J.W., DeWeese, T.L. Synergism of Ionizing Radiation and Gene Therapy with the Replication Competent CN706 Adenovirus in the LAPC-4 Prostate Cancer Cell Line. J Urol, 161:62, 1999.

     

  18. DeWeese, T.L. , Shipman, J.M., Buckley, N.M., Hopkins, L.A., Riele, H., Nelson, W.G. Cellular Resistance to FUdR is Associated with Defective DNA Mismatch Repair. Proc Am Assoc Cancer Res, 40:139, 1999.

     

  19. Ramakrishna, N,.R., Rioseco-Camacho, N., Sawyers, C.L., Yu, C.De., Henderson, D., Simons, J.W., DeWeese, T.L. Synergism of Ionizing Radiation and Gene Therapy with the Replication Competent CN706 Adenovirus in the LAPC-4 Prostate Cancer Cell Line. Proc Am Assoc Cancer Res, 40:630, 1999.

     

  20. Li, S., DeWeese T.L., Ramakrishna, N., Detorie, N., Hamper, U., Simons, J. Three-Dimensional Treatment Planning for Transrectal Ultrasound-Guided Cytolytic Adenoviral Gene Therapy, Part I. Proc Am Assoc Physicists Med, 26:1121, 1999.

     

  21. Li., S., DeWeese, T.L. , Hamper, M., Simons, J., Three-Dimensional Treatment Planning for Transrectal Ultrasound-Guided Cytolytic Adenoviral Gene Therapy, Part II. Proc Am Assoc Physicists Med, 26:1121, 1999.

     

  22. Li., S., DeWeese, T.L. , Lee, D., Wharam, M., Frankel, T., Dicello, J. A Moving-Frame Method in HDR Brachytherapy. Proc Am Assoc Physicists Med, 26:1141, 1999.

     

  23. DeWeese, T.L. , Ramakrishna, N., Demarzo, A., Rodriguez, R., Li, S., Detorie, N., Goemann, M., Mikhak, B., Simons, J.W. Bioactivity of CN706, A PSA Specific Oncolytic Adenoviral Vector: A Phase I Trial of In Vivo Gene Therapy for Locally-Recurrent Prostate Cancer Following Radiation Therapy. Int J Radiat Oncol Biol Phys, 45(3):356, 1999.

     

  24. Ramakrishna, N.R., Rioseco-Camacho, N., Sawyers, C.L., Yu, D.C., Henderson, D., Simons, J.W., DeWeese, T.L. Mechanisms of Therapeutic Synergy Between Radiation Treatment and Adenoviral Gene Therapy with the Replication Competent PSA-Specific Vector CN706 in The LAPC-4 and LnCaP Prostate Cancer Cell Lines. Int J Radiat Oncol Biol Phys, 45(3):300, 1999.

     

  25. DeWeese, T.L. , Ramakrishna, N., DeMarzo, A., Rodriguez, R., Li, S., Drew, R., Goemann, M., Mikhak, B., Hamper, U., DeJong, R., Simons, J. A Phase I Trial of In Vivo Gene Therapy for Locally-Recurrent Prostate Cancer Following Radiation Therapy Using CN706, A PSA-Selective Cytolytic Adenovirus. Int J Radiat Oncol Biol Phys, 46:786, 2000.

     

  26. DeWeese, T.L. , Mikhak, B., Ramakrishna, N., DeMarzo, A.M., Rodriguez, R., Goemann, M.A., Drew, R., Li, S., Hamper, U., DeJong, M.R., Detorie, N., Simons, J.W. Bioactivity of CN706, A PSA Selective Oncolytic Adenoviral Vector: A Phase I Trial of In Vivo Gene Therapy for Locally-Recurrent Prostate Cancer Following Radiation Therapy. Proc Am Assoc Cancer Res, 41:123, 2000.

  27. Ramakrishna, N., Rioseco-Comacho, N.S., Nielsen, M.E., Wu, X., Yu, D.C., Henderson, D.R., Simons, J.W., DeWeese, T.L. Ionizing Radiation Enhances Therapeutic Efficacy and Replication of the Oncolytic Adenovirus CN706 in the LNCAP Prostate Cancer Cell Line. Proc Am Assoc Cancer Res, 41:731, 2000.

     

  28. Hopkins, L.A., Shipman, J.M., Buckley, N.M., Zahurak, M.L., Sokoll, L.J., Chan, D.W., Simons, J.W., Nelson, W.G. and DeWeese, T.L. Basic fibroblastic growth factor in human prostate cancer: In vitro and human studies of radiation-induced modulation. Int J Rad Onc Biol Phys, 48: 282, 2000.

     

  29. Hopkins, L.A., Kirchner, J., Kuhn, Y., Nelson, W., Stephens, J., Krochak, K., Scott, S., and DeWeese, T.L. The DNA Mismatch Repair Protein, Msh2, is involved in the Cellular Response to Hypoxic Exposures. Proc Am Assoc Cancer Res, 42: 571, 2001.

     

  30. DeWeese, T.L. , Chen, Y., Scott, S., Stephens, J., Henderson, D., and Yu, D.C. Significant Synergy Exists Between CV706, a PSA-selective, Replication-Competent Adenovirus and Radiation in the Treatment of Human Prostate Cancer. Int J Rad Onc Biol Phys, 51: 115, 2001.

     

  31. Parker, A.R., O’Meally, R., Oliver, D.H., Hua, L., Nelson, W.G., DeWeese, T.L. , and Eshleman, J.R. 7,8-dihydro-8-oxo-deoxyguanosine repair is defective in some microsatellite stable colorectal cancer cells. Proc Am Assoc Cancer Res, 43:56, 2002.

     

  32. Lapidus, R.G., Dang, W., Gady, A., Rosen, M.., DeWeese, T.L. , and Denmeade, S.R. Effect of intratumoral controlled release Paclitaxel (Paclime® Microspheres) and radiation on prostate cancer models. Proc Am Assoc Cancer Res, 43: 190, 2002

     

  33. Collis, S., Ketner, G., and DeWeese, T.L. Expression of adenovirus E4orf6 as a potential radiation sensitization strategy. Proc Am Assoc Cancer Res, 43: 229, 2002.

     

  34. Parker, A.R., O’Meally, R.N., Nelson, W.G., DeWeese, T.L. , and Eshleman, J.R. Phosphorylation regulates repair of adenine:8-oxoguanine (A:8-oxoG) mispairs in microsatellite stable colorectal cancer cell lines. Proc Am Assoc Cancer Res, 44: 335, 2003.

     

  35. Collis, S., Swartz, M., Nelson, W.G., and DeWeese, T.L. Enhanced radiation and chemotherapy-mediated cell killing of human cancer cells by siRNA-silencing of DNA repair factors. Proc Am Assoc Cancer Res, 44: 436, 2003.

     

  36. Parker, A.R., O’Meally, R.N., Oliver, D.H., Nelson, W.G., DeWeese, T.L. , and Eshleman, J.R. Stable antisense human mutY in microsatellite stable colorectal cancer cell lines is directly associated with elevation of the mutagenic base 8-oxoguanine. Proc Am Assoc Cancer Res, 44: 440, 2003.

     

  37. Collis, S.J., Hopkins, L.A., Schwaninger, J.M., Drost, M.L., Faith, D.A., Isaacs, W.B., Eschleman, J.R., Piantadosi, S., DeWeese, T.L. Elevated mutation frequency results from exposure of Msh2 cells to oxidative injury inflicted by protracted low dose-rate radiation. Proc Am Assoc Cancer Res, 45: 327, 2004.

     

  38. Collis, S.J., Schwaninger, J., Ntambi, A., Keller, T., Dillehay, L., Nelson, W., and DeWeese, T.L. Low-level radiation–induced DNA damage evades early cellular response mechanisms leading to increased cell death. ASTRO Meeting Proceedings, #2012, 2004.

Articles Published in Professional Journals

BOOKS CHAPTER
  1. Ramakrishna, N.R. and DeWeese, T.L. : Radiation Therapy as Applied to Prostate Cancer: Clinical, Technical and Biologic Considerations, in Prostate Cancer in the 21st Century. Ed. Chung, L.W.K., Isaacs, W.B., Simons, J.W., Humana Press, 387-413, 1999.

     

  2. DeWeese, T.L. : Bladder-Preserving Strategies, in The Guide to Living with Bladder Cancer. Ed. Schoenberg, M.P., Johns Hopkins Press, 112-122, 2000.

     

  3. Thurman, S.A., Ramakrishna, N.R., and DeWeese, T.L. : Radiation Therapy for the Treatment of Locally Advanced and Metastatic Prostate Cancer, in Hematology/Oncology Clinics of North America. Ed. Carducci, M.A., Eisenberger, M.A., W.B.Saunders Company, Philadelphia, 423-443, 2001.

     

  4. Nelson, W.G., DeWeese, T.L. , DeMarzo, A.M., and Brooks, J.D. Prostate Cancer Prevention, in Prostate Cancer: Principles and Practice. Lippincott Williams & Wilkins, pg 103, 2001.

     

  5. D’Amico, A.V., Crook, J., Beard, C.J., Hurwitz, M., Kaplan, I., and DeWeese, T.L. Radiation Therapy for Prostate Cancer, in Campbell’s Urology; Eighth Edition. Elsevier Science, pg 3147-3171, 2002.

     

  6. Ramakrishna, N.R., Li, Shidong, Detorie, N. Simons, J.W. and DeWeese, T.L. : Prostate Cancer Gene Therapy, in Prostate Cancer - Scientific and Clinical Aspects. Bridging the Gap between Clinicians and Scientists. Ed. Abel, P.D. and Lalani, E-N; Imperial College Press, UK, 2003.

     

  7. Nelson, W.G., Carter, B., DeWeese, T.L. , Bajaj, G., Thompson, T.L., and Eisenberger, M.A.: Prostate Cancer, in Clinical Oncology. Ed. Abeloff, Armitage, Kastan, and Niederhuber, 2003.
 
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