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Bruce J. Trock, Ph.D. Shawn E Lupold, Ph.D.
Associate Professor of Urology and Oncology
Johns Hopkins University School of Medicine
Co-Director
Sidney Kimmel Comprehensive Cancer Center Prostate Cancer Program
Secondary Appointments and Affiliations
Radiation Oncology and Molecular Radiation Sciences
Johns Hopkins Institute for NanoBioTechnology

       

Shawn E. Lupold, Ph.D., is Associate Professor of Urology and Oncology and co-director of the Prostate Cancer Program for the Sidney Kimmel Comprehensive Cancer Center.  Dr. Lupold was trained as a Pre-IRTA fellow in the Laboratory of Human Carcinogenesis at the National Cancer Institute and received his Ph.D. in Pharmacology and Molecular Sciences from the Johns Hopkins University School of Medicine.  He further trained in prostate cancer research as a post doctoral fellow in the Brady Urological Research Institute at Johns Hopkins.

The Lupold laboratory focuses on prostate cancer biology with the goal of exploiting prostate tissue-specificity to develop new diagnostic, prognostic and therapeutic agents.  Research projects stem from basic cancer biology, such as studying the role of microRNAs in the prostate cancer phenotype, to translational projects such as targeted siRNA and gene therapy.  One area of interest is high diversity polymer libraries, including aptamers and peptides, which can be screened to identify high affinity cancer ligands.  With this approach Dr. Lupold developed the first RNA aptamers targeted to a cancer cell surface antigen.  He and others have applied these PSMA-targeting aptamers to deliver various therapeutic and imaging packages to prostate cancer cells and tumors. 

EDUCATION


1988- 1992

B.S., Biology; Dept of Life Sciences,
University of Maryland, College Park, MD

1993-1995

Pre-IRTA Fellow, Laboratory of Human Carcinogenesis,
National Institutes of Health, National Cancer Institute, Bethesda, MD

1995-2001 

Ph.D., Department of Pharmacology and Molecular Sciences,        
Biochemistry, Cellular, and Molecular Biology Graduate Program
The Johns Hopkins University School of Medicine, Baltimore, MD

2001-2005

Post Doctoral Fellow, Department of Urology,
The Johns Hopkins University School of Medicine, Baltimore, MD

 

PATENTS

  1. Lupold SE, Lin Y, Hicke BJ, Coffey DS. “Nucleic Acid Ligands to the Prostate Specific Membrane Antigen” US 6,933,114. Awarded 08/23/05

  2. Rodriguez R., Lupold SE, and Chowdhury WH “Peptides for Targeting the Prostate Specific Membrane Antigen” US 7,749,986. Awarded 07/06/2010

  3. Rodriguez R., Lupold SE, and Chowdhury WH, Kudroli, TA  “Adenoviral fiber exchange shuttle system”. US 8,088,621. Awarded 01/03/12

  4. Lupold SE, Rodriguez R, Chowdhury WH, and Kudrolli TA.  “Compositions and methods for generating and screening adenoviral libraries”. USPA 20090074658, March 19, 2009

  5. Lupold SE, DeWeese TL, Ni X, and Zhang Y. “Radiation sensitization agents for prostate cancer”. USPA 20130123566, May 16, 2013

  6. Lupold SE, Wu P, and Rodriguez R. “Compositions and methods for retargeting virus constructs”. USPA 20130315870, November 28, 2013

  7. Lupold SE, Chowdhury WH, Wu P, and Rodriguez R. “Compositions and methods for detecting and quantifying circulating tumor cells (CTCs).  USPA 20140017668, January 16, 2014

PUBLICATIONS

Free Access to abstracts at PubMed


  SELECTED PUBLICATIONS
  1. Mukherjee A, Castanares M, Hedayati M, Wabler M, Trock B, Kulkarni P, Rodriguez R, Getzenberg RH, DeWeese TL, Ivkov R*, and Lupold SE*. Monitoring nanoparticle mediated cellular hyperthermia with a high sensitivity biosensor.  Nanomedicine (Lond). 2014.  February 18.  [Epub ahead of Print]

  2. Mukherjee A, Darlington T, Baldwin R, Holz C, Olsen S, Kulkarni P, DeWeese TL, Getzenberg RH, Ivkov R and Lupold SE.  Development and screening of a series of antibody-conjugated and silica coated ironoxide nanoparticles for targeting the Prostate Specific Membrane Antigen.  ChemMedChem 2014, March 3.  [EPub ahead of Print].

  3. Ribas J, Ni X, Castanares M, Liu M, Rodriguez R, Mendell JT, and Lupold SE. A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts.  Nucleic Acids Research 2012; doi: 10.1093/nar/gks308

  4. Lupold SE, Johnson T, Chowdhury WH, and Rodriguez R.  A real time Metridia Luciferase based non-invasive reporter assay of mammalian cell viability and cytotoxicity via the β-actin promoter and enhancer.  PLoS ONE 7(5): e36535, 2012

  5. Ni X, Castanares M, Mukherjee A, and Lupold SE.  Nucleic Acid Aptamer: clinical applications and promising new horizons.  Cur Med Chem. 18(27), 4206-4214, 2011

  6. Ni X, Zhang Y, Ribas J, Chowdhury WH, Castanares M, Zhang Z, Laiho M, DeWeese TL, Lupold SE. Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts.  Journal of Clinical Investigation.  J Clin Invest. 2011 Jun 1;121(6):2383-90.

  7. Wu P, Kudrolli TA, Chowdhury WH, Minzhi ML, Rodriguez R, and Lupold SE.  Adenovirus Targeting to Prostate-specific Membrane Antigen through Virus displayed Semi-random Peptide Library Screening.  [Priority Report] Cancer Res. 2010 Dec 1;70(23):9549-53.

  8. Ribas J and Lupold SE.  The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer. Cell Cycle; 9(5), 923-9, 2010

  9. Ribas J, Ni X, Haffner M, Wentzel EA, Salmasi1 AH, Chowdhury WE, Kudrolli TA, Yegnasubramanian A, Luo J, Rodriguez T, Mendell JT, Lupold SE.  miR-21:  An androgen receptor regulated microRNA which promotes hormone dependent and independent prostate cancer growth.  Cancer Research. [Priority Report]  69(18): 7165-9, 2009   

  10. Lupold SE., Kudrolli T., Chowdhury W., Wu P, and Rodriguez R. "A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber" Nucl. Acids Res. 35(20):e138, 1-10, 2007

  11. Lupold SE, Rodriguez R.  "Adenoviral Vectors for Prostate Cancer Gene Therapy" Cancer Therapy, Vol 3, 267-284, 2005

  12. Lupold SE, Rodriguez R. "Adenoviral Gene Therapy, Radiation, and Prostate  Cancer" Reviews in Urology; Vol 7(4), 193-202. Fall 2005

  13. Lupold SE., Rodriguez R.  Disulfide-Constrained Peptides that Bind to the Extracellular Portion of the Prostate Specific Membrane Antigen.  Mol Cancer Ther. 3(5):597-603, 2004

  14. Lupold SE., Hicke B.J., Lin Y., Coffey DS. Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen. Cancer Research. 62(14):4029-33, 2002.

  BOOK CHAPTERS
  1. Ribas J and Lupold SE.  Role of miR-21, and androgen-regulated microRNA, in prostate cancer, In Androgen Responsive Genes in Prostate Cancer, Springer, 2012Chapter 18, in Androgen-Responsive Genes in Prostate Cancer.  Regulation, Function and Clinical Applications.  Springer, 2013

  2. Byun Y, Mease RC, Lupold SE, Pomper MG. Recent Development of Diagnostic and Therapeutic Agents Targeting Glutamate Carboxypeptidase II (GCPII), Chapter 36, In Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications.  Wiley, 2009

  OTHER MEDIA
  1. Lupold SE.  Molecular Approaches to Prostate Cancer, Johns Hopkins Medicine Podcast, 2008

MEMBERSHIP IN PROFESSIONAL ORGANIZATIONS

  • 1999-Present            American Association for Cancer Research

  • 2003-Present            American Society of Gene and Cell Therapy

  • 2006-Present            Society for Basic Urologic Research

  • 2009-Present           Johns Hopkins Institute for NanoBioTechnology

AWARDS & HONORS

1993  Pre-doctoral Intramural Research Training Award (IRTA)
2004   Prostate Cancer Foundation Career Development Award
2005  CPDR Distinguished Lecturer
2006   Virginia and Warren Schwerin Scholar
2007 BioVision.Nxt Fellow
2008 Department of Defense PCRP New Investigator
Award
2009 Society for Basic Urologic Research Young
Investigator Award
2009 Phyllis and Brian L. Harvey Scholar

   CONTACT INFORMATION

 

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