Robert H. Getzenberg, Ph.D. Research Director Johns Hopkins Medical Institutions Email:rgetzen1@jhmi.edu

   REFEREED ARTICLES.

1. Nath, P., Getzenberg, R.H., Beebe, D., Pallansch, L. and Zelenka, P. c-myc mRNA is Elevated as Differentiating Lens Cells Withdraw From the Cell Cycle. Experimental Cell Research 169; 215-222, 1988.
2. Getzenberg, R.H. and Coffey, D.S. Tissue Specificity of the Hormonal Response in Sex Accessory Tissues is Associated with Nuclear Matrix Protein Patterns. Molecular Endocrinology, 4(9):1336-1342, 1990.
3. Getzenberg, R.H., Pienta, K.J. and Coffey, D.S. The Tissue Matrix: Cell Dynamics and Hormone Action. Endocrine Reviews, 11(3): 399-417, 1990.
4. Boyd, J., Pienta, K.J., Getzenberg, R.H., Coffey, D.S. and Barrett, J.C. Preneoplastic Alterations in Nuclear Morphology that Accompany Loss of the Tumor Suppressor Phenotype. Journal of the National Cancer Institute. 83(12):862-866, 1991.
5. Pienta, K.J., Murphy, B.C., Getzenberg, R.H. and Coffey, D.S. The Effect of Extracellular Matrix Interactions on Morphologic Transformation in vitro. Biochemical and Biophysical Research Communications, 179(1):333-339, 1991.
6. Getzenberg, R.H., Pienta, K.J., Huang, E.Y.W., Murphy, B.C. and Coffey, D.S. Modifications of the Intermediate Filament and Nuclear Matrix Networks by the Extracellular Matrix. Biochemical and Biophysical Research Communications, 179(1):340-344, 1991.
7. Getzenberg, R.H., Pienta, K.J., Huang, E.Y.W. and Coffey, D.S. Identification of Nuclear Matrix Proteins in the Cancer and Normal Rat Prostate. Cancer Research, 51(24):6514-6520, 1991.
8. Pienta, K.J., Getzenberg, R.H. and Coffey, D.S. Cell Structure and DNA Organization. Critical Reviews in Eukaryotic Gene Expression, 1(4):355-385, 1991.
9. Getzenberg, R.H., Pienta, K.J., Ward, W.S. and Coffey, D.S. Nuclear Structure and the Three-Dimensional Organization of DNA. Journal of Cellular Biochemistry, 47:289-299, 1991.
10. Pienta, K.J., Getzenberg, R.H. and Coffey, D.S. Characterization of Nuclear Morphology and Nuclear Matrices in Ageing Human Fibroblasts. Mechanisms of Ageing and Development, 62:13-24, 1992.
11. Partin, A.W., Getzenberg, R.H., CarMichael, M.J., Vindivich, D., Yoo, J., Epstein, J.I., and Coffey, D.S. Nuclear Matrix Protein Patterns in Human Benign Prostatic Hyperplasia and Prostate Cancer. Cancer Research, 53(4):744-746, 1993.
12. Getzenberg, R.H. The Nuclear Matrix and the Regulation of Gene Expression: Tissue Specificity. J. Cell. Biochem., 55(1):22-31, 1994.
13. Pierceall, W.E., Cho, K.R., Getzenberg, R.H., Reale, M.A., Hedrick, L., Vogelstein, B., and Fearon, E.R. NIH3T3 Cells Expressing the Deleted in Colorectal Cancer Gene Product Stimulate Neurite Outgrowth in Rat PC12 Pheochromocytoma Cells. J. Cell Biol., 124(6):1017-1027, 1994.
14. Reale, M.A., Hu, G., Zafar, A.I., Getzenberg, R.H., Levine, S.M., and Fearon, E.R. Expression and Alternative Splicing of the Deleted in Colorectal Cancer (DCC) Gene in Normal and Malignant Tissues. Cancer Research, 54(16):4493-4501, 1994.
15. Osborn, J.L., Getzenberg, R.H., and Trump, D.L. Spinal Cord Compression in Prostate Cancer. J. Neuro-Onc., 23(2):135-147, 1995.
16. Nardozza, T.A., Quigley, M.M., and Getzenberg, R.H. Association of Transcription Factors with the Nuclear Matrix. Journal of Cellular Biochemistry, 61(3):467-477, 1996.
17. Getzenberg, R.H., Konety, B.R., Oeler, T.A., Quigley, M.M., Hakam, A., Becich, M.J., and Bahnson, R.R. Bladder Cancer Associated Nuclear Matrix Proteins. Cancer Research, 56:1690-1694, 1996.
18. Replogle-Schwab, T.S., Pienta, K.J., and Getzenberg, R.H. The Utilization of Nuclear Matrix Proteins for Cancer Diagnosis. Critical Reviews in Eukaryotic Gene Expression, 6(1&2):103-113, 1996.
19. Replogle-Schwab, T.S., Getzenberg, R.H., Donat, T.L., and Pienta, K.J. The Effect of Organ Site of Nuclear Matrix Protein Composition. Journal of Cellular Biochemistry, 62(1), 132-141, 1996.
20. Konety, B.R., Getzenberg, R.H., and Bahnson, R.R. Diagnostic and Prognostic Markers in Bladder Cancer. Contemporary Urology, 8(7), 15-35, 1996.
21. Konety, B.R., Schwartz, G.G., Acierno, J.S., Becich, M.J., and Getzenberg, R.H. The Role of Vitamin D in Normal Prostatic Growth and Differentiation. Cell Growth and Differentiation, 7, 1563-1570, 1996.
22. Getzenberg, R.H., Light, B.W., Lapco, P.E., Konety, B.R., Nangia, A.K., Acierno, J.S., Dhir, R., Shurin, Z., Day, R.S., Trump, D.L., and Johnson, C.S. Vitamin D Inhibition of Prostate Adenocarcinoma Growth and Metastasis in the Dunning Rat Prostate Model System. Urology, 50(6), 999-1006, 1997.
23. Konety, B.R., Nangia, A.K., Nguyen, T-S. T., Veitmeier, B.N., Dhir, R., Acierno, J.S., Becich, M.J., Hrebinko, R., and Getzenberg, R.H. Identification of Nuclear Matrix Protein Alterations Associated with Renal Cell Carcinoma. Journal of Urology, 159, 1359-1363, 1998.
24. Nangia, A.K., Butcher, J., Konety, B.R., and Getzenberg, R.H. Association of Vitamin D Receptors with the Nuclear Matrix of Human and Rat Genitourinary Tissues. Journal of Steroid Biochemistry and Molecular Biology, 66(4), 241-246, 1998.
25. Green, J.E., Greenberg, N.M., Ashendel, C.L., Barrett, J.C., Boone, C., Getzenberg, R.H., Henkin J., Matusik, R., Janus, T.J., and Scher, H.I. Workgroup 3: Transgenic and Reconstitution Models of Prostate Cancer. Prostate, 36(1), 59-63, 1998.
26. Tang, Y., Getzenberg, R.H., Vietmeier, B.N., Sallcup, M.R., Eggert, M., Renkawitz, R., and DeFranco, D.B. The DNA-Binding and ?2 Transactivation Domains of the Rat Glucocorticoid Receptor Constitute a Nuclear Matrix Targeting Signal. Molecular Endocrinology, 12(9), 1420-1431, 1998.
27. Konety, B.R., Nangia, A.K., Nguyen, T-S.T., and Getzenberg, R.H. Effect of pre-natal vitamin D (calcitriol) exposure on the growth and development of the prostate and premature death. The Prostate, 41(3), 181-189, 1999.
28. Horton, M.J. and Getzenberg, R.H. Rat Seminal Vesicle Secretory Protein SVS-II Binds DNA with a Preference for 5’ Regulatory Regions of Secretory Protein Genes: Presence Among Components of the Nuclear Matrix. Journal of Andrology, 20(2): 7, 1999.
29. Krill, D., Stoner, J., Konety, B.R., Becich, M.J., and Getzenberg, R.H. Differential Effects of Vitamin D on Normal Human Prostatic Epithelial and Stromal Cells in Primary Culture. Urology, 54 (1) 171-177, 1999.
30. Pirtskalaishivili, G., Getzenberg, R. H., and Konety, B. R. Use of Urine-Based Markers for Detection and Monitoring of Bladder Cancer. Techniques in Urology, 5 (4): 179-184, 1999.
31. Konety, B. R. and Getzenberg, R. H. Nuclear Structural Proteins as Biomarkers of Cancer. Journal of Cellular Biochemistry. 32/33: 183-191, 1999.
32. Pirtskalaishvili, G., Konety, B. R., Getzenberg, R. H. Update on Urine-Based Markers for Bladder Cancer. Postgraduate Medicine, 106 (6): 85-94, 1999.
33. Konety, B. R., Leman, E., Vietmeier, B., Arlotti, J. A., Dhir R., and Getzenberg, R. H. In vitro and In vivo Effects of Vitamin D (calcitriol) Administration on the Normal Neonatal and Pre-Pubertal Prostate. Journal of Urology, 164, 1812-1818, 2000
34. Konety, B. R., Nguyen, T-S.T., Brenes, G., Sholder, A., Lewis, N., Bastacky, S., Potter, D., and Getzenberg, R. H. Clinical Usefulness of the Novel Marker, BLCA-4, for the Detection of Bladder Cancer. Journal of Urology, 164: 634-639, 2000.
35. Konety, B. R., Nguyen, T-S.T., Brenes, G., Lewis, N., Saul, M., Nelson, J. B., and Getzenberg, R. H. Evaluation of the Effect of Spinal Cord Injury (SCI) on serum PSA levels, Urology, 56: 82-86, 2000.
36. Konety, B.R., Nguyen, T-S.T., Dhir, R., Day, R., Stadler, W.M., Becich, M.J., and Getzenberg, R.H. Detection of Bladder Cancer Using a Novel Nuclear Matrix Protein, BLCA-4. Clinical Cancer Research, 6: 2618-2625, 2000.
37. Davido, T., and Getzenberg, R.H. Nuclear Matrix as Cancer Markers. Journal of Cellular Biochemistry, 999:35: 136-141, 2000.
38. Konety, B. R., Lavelle, J. P., Pirtskalaishvili, G., Dhir, R., Meyers, S. A., Nguyen, T-S.T., Hershberger, P., Shurin, M. R., Johnson, C. S., Trump, D. S., Zeidel, M. L., and Getzenberg, R. H. Effects of Vitamin D (calcitriol) on Transitional Cell Carcinoma of the Bladder In Vitro and In Vivo. Journal of Urology, 165: 253-258, 2001.
39. Arlotti, J.A., Cimino, T.S., Nguyen T-S, T., Jaynes, J.M., Caldwell, A.L., Jr., McKenna, M.J., and Getzenberg, R.H. Efficacy of a Synthetic Lytic Peptide in the Treatment of Prostate Cancer. Urologic Oncology, 6/3: 97-102, 2001.
40. Krill, D., DeFlavia, P., Dhir, R., Luo, J., Leman, E. Becich, M.J., and Getzenberg, R.H. Expression Patterns of Vitamin D Receptor in Human Prostate. Journal of Cellular Biochemistry 82: 566-572 2001.
41. Konety, B.R. and Getzenberg, R.H. Urine Based Markers of Urological Malignancy. Journal of Urology, 165: 600-611, 2001.
42. Brunagel, G., Vietmeier, B.N., Bauer, A.J., Schoen, R.E., and Getzenberg, R.H. Identification of Nuclear Matrix Protein Alterations Associated with Human Colon Cancer. Cancer Research, 62:2437-2442, 2002.
43. Kulkarni, P., Pirozzi, G., Elashoff, M., Munger, W., Waga, I., Dhir, R., Kakehi, Y., and Getzenberg, R.H. Symptomatic and Asymptomatic Benign Prostatic Hyperplasia: Molecular Differentiation Using Microarrays. Proceedings of the National Academy of Sciences, 11:7598-7603, 2002.
44. Konety, B.R., Somogyi, G., Atan, A., Muindi, J., Chancellor, M.B., and Getzenberg, R.H. Evaluation of Intra-Prostatic Metabolism of 1,25 Dihydroxyvitamin D3 (Calcitriol) Using a Microdialysis Technique. Urology, 59:947-952, 2002.
45. Davido, H. T. and Getzenberg, R.H. Utilization of a Urine-Based Assay for BLCA-4 in the Detection of Bladder Cancer. Journal of Clinical Ligand Assay, 25:85-86, 2002.
46. Leman, E.S., Arlotti, J.A., Dhir, R., Greenberg, N., and Getzenberg R.H. Characterization of the Nuclear Matrix Proteins in a Transgenic Mouse Model and Prostate Cancer. Journal of Cellular Biochemistry, 86:203-212, 2002.
47. Leman, E.S., and Getzenberg, R.H. Nuclear Matrix Proteins as Biomarkers in Prostate Cancer. Journal of Cellular Biochemistry, 86:213-223, 2002
48. Brunagel, G., Vietmeier, B.N., Bauer, A.J., Schoen, R.E., and Getzenberg, R.H. Nuclear Matrix Protein Alterations Associated with Colon Cancer Metastasis to the Liver. Clinical Cancer Research, 8: 3039-3045, 2002
49. Konety, B.R., Getzenberg, R.H. Vitamin D and Prostate Cancer. Urologic Clinics of North America, 29:95-106, 2002.
    
    
50. Leman, E.S., DeMiguel, F., Gao, A.C., and Getzenberg, R.H. Regulation of Androgen and Vitamin D Receptors by 1,25-dihydroxyvitamin D3 in Human Prostate Epithelial and Stromal Cells. Journal of Urology, 170:235-240, 2003.
51. Leman, E.S., and Getzenberg, R.H. The Effects of 1,25-Dihydroxyvitamin D3 on the Distribution of Androgen and Vitamin D Receptors in Human Prostate Neonatal Epithelial Cells. Journal of Cellular Biochemistry, 88: 609-622, 2003.
52. Leman, E.S., Madigan, M.C., Brunagel, G., Takaha, N., Coffey, D.S. and Getzenberg, R.H. Nuclear Matrix Localization of High Mobility Group Protein I (Y) in a Transgenic Mouse Model for Prostate Cancer. Journal of Cellular Biochemistry, 88:599-608, 2003.
53. Brunagel, G., Shah, U., Schoen, R.E., and Getzenberg, R.H. Identification of Calreticulin as a Nuclear Matrix Protein Associated with Human Colon Cancer. Journal of Cellular Biochemistry, 89:238-243, 2003.
54. Leman, E.S., Arlotti, J.A., Dhir, R., and Getzenberg, R.H. Vitamin D and Androgen Regulation of Prostatic Growth. Journal of Cellular Biochemistry, 90: 138-147, 2003.
55. Getzenberg, R.H. Urine-Based Assays for Bladder Cancer. Laboratory Medicine, 34: (8) 613-617, 2003.
56. Sakamoto, S., Yokoyama, M., Prakash, K., Tsuruha, J-I., Masamoto, S., Getzenberg, R.H. and Kakehi, Y. Development of Quantitative Detection Assays for CYR61 as a New Marker for Benign Prostatic Hyperplasia. Journal of Biomolecular Screening, 8: No: 6: 701-711, 2003.
57. Kasai, M., Guerrero-Santoro, J., Friedman, R., Leman E.S., Getzenberg, R.H. and DeFranco, D. B. The Group 3 LIM Domain Protein Paxillin Potentiates Androgen Receptor Transactivation in Prostate Cancer Cell Lines. Cancer Research, 63: 4927-4935, 2003.
58. Kakehi, Y., Segawa, T., Wu, X-X., Kulkarni, P., Dhir, R., and Getzenberg, R.H. Down-regulation of Macrophage Inhibitory Cytokine-1/Prostate Derived Factor in Benign Prostatic Hyperplasia. The Prostate, 59: 351-356, 2004.
59. Dhir, R., Vietmeier, B., Arlotti, J., Acquafondata, M., Landsittel, D. Getzenberg, R.H. Early Identification of Individuals with Prostate Cancer in “Negative Biopsies”. J. of Urology, 171:1419-1423, 2004.
60. Guzey, M., Arlotti, J., Acquafondata, M., Jukic, D., Dhir, R., and Getzenberg, R.H. Increased Apoptosis of Periprostatic Adipose Tissue in VDR Null Mice. Journal of Cellular Biochemistry, 93: 133- 141, 2004.
61. Guzey, M., Luo J. and Getzenberg, R.H. Vitamin D3 Modulated Gene Expression Patterns in Primary Prostate Normal and Cancer Cells. Journal of Cellular Biochemistry, 93:271-285, 2004.
62. Shah, U.S., and Getzenberg, R.H. Fingerprinting the Diseased Prostate: Association Between BPH and Prostate Cancer. Journal of Cellular Biochemistry, 91:161-169, 2004.
63. Brunagel, G., Schoen, R.E., and Getzenberg, R.H. Colon Cancer Specific Nuclear Matrix Protein Alterations in Human Colonic Adenomatous Polyps. Journal of Celluar Biochemistry, 91: 365-374, 2004.
64. Van Le, T-S.T., Myers, J., Konety, B.R., Barder, T., and Getzenberg, R.H. Functional Characterization of the Bladder Cancer Marker, BLCA-4. Clinical Cancer Research, 10: 1384-1391, 2004.
65. Shah, U.S., Arlotti, J., Dhir, R., Lu, S., Pirozzi, G., Prakash, K., and Getzenberg, R.H. Androgen Regulation of JM-27 is Associated with the Diseased Prostate. Journal of Andrology, 25: 618-624, 2004.
66. Sakamoto, S., Yokoyama, M., Zhang, X., Prakash, K., Nagao, K., Hatanaka, T., Getzenberg, R.H., and Kakehi, Y. Increased Expression of CYR61, an Extracellular Matrix Signaling Protein, in Human Benign Prostatic Hyperplasia and Its Regulation by Lysophosphatidic Acid. Endocrinology, 145:(6) 2929-2940, 2004.
67. Myers, J.M., Landsittel, D., and Getzenberg, R.H. Use of novel marker, BLCA-1, for the detection of
    bladder cancer. Journal of Urology, 174:(1) 64-68, 2005.

68. Ouyang, D.L., Chen, J.J., Getzenberg, R.H., and Schoen, R.E. Non-Invasive Testing for Colorectal Cancer: A Review. American J. of Gastroenterology, 100:(6) 1393-1403, 2005.

69. Minnery, C. and Getzenberg, R.H. BPH Cell Viability and Modulation of JM-27 by Doxazosin and Ibuprofen. Journal of Urology, 173:(1) 375-379, 2005.

70. Van Le, T-S.T., Miller, R., Barder, T., Babjuk, M., Potter D.M., and Getzenberg, R.H. A Highly Specific Urine-Based Marker of Bladder Cancer. Urology, in press, 2005.

71. Paul, B., Dhir, R., Landsittel, D., Hitchens, M.R., and Getzenberg, R. H.Detection of Prostate Cancer with a Blood-Based Assay for EPCA.Cancer Research, 65:(10), 4097-100, 2005.

72. Davies, B., Chen, J., Leiras, C., Modugno, F.M., Landsittel, D., Dhir, R., Nelson, J., and Getzenberg, R.H.  Contribution of the Prostate Limits the Utility of Survivin in the Detection of Bladder Cancer.Journal of Urology, in press, 2005.

73. Davies, B., Chen, J., McMurray, T., Landsittel, D., Lewis, N., Brenes, G., and Getzenberg, R. H. Efficacy of BTA Stat, Survivin, and Cytology in Bladder Cancer Surveillance over Five Years in Spinal Cord Injury Patients. Urology, in press, 2005.

74. Myers-Irvin, J., Van Le, T., and Getzenberg, R. H. Mechanistic Analysis of the Role of BLCA-4 in Bladder Cancer Pathobiology. Cancer Research, 65:(16), in press, 2005.

Nagatomi, J., DeMiguel, F., Torimoto, K., Chancellor, M. B., Getzenberg, R. H. and Sacks, M.  Early molecular-level changes in rat bladder wall tissue following spinal cord injury.  Biochemical and Biophysical Research Communications 334, 1159-1164, 2005.

    BOOKS, CHAPTERS AND REVIEWS.

1. Getzenberg, R.H., and Coffey, D.S. Tissue Specificity and Cell Death are Associated with Specific Alterations in Nuclear Matrix Proteins, In: Karr, J.P., Tindall, D.J., Coffey, D.S., and Smith, R.G. (eds) Molecular and Cellular Biology of Prostate Cancer, Plenum Press, New York, pg 1-13, 1989.

2. Pienta, K.J., Murphy, B.C., Getzenberg, R.H., and Coffey, D.S. The Tissue Matrix and the Regulation of Gene Expression in Cancer Cells. Advances in Molecular and Cellular Biology, 7:131-156, 1993.

3. Getzenberg, R.H. Book Review of Essential Endocrinology. The Physiologist, 409, 1996

4. Getzenberg, R.H. The Tissue Matrix: Cell Signaling and Hormone Regulation. In: Bittar, E.E. and Bittar, N. (eds) Principles of Medical Biology, JAI Press, Inc., Greenwich, CT, 10B:643-662, 1997.

5. Konety, B.R. and Getzenberg, R.H. Novel Therapies for Advanced Prostate Cancer. Seminars in Urologic Oncology, 15(1):33-42, 1997.

6. Horton, M.J. and Getzenberg, R.H. The Role of the Nuclear Matrix in Tissue Specific Gene Expression. In: Getzenberg, R.H. (ed.) Cell Structure and Signalling, JAI Press Inc., Greenwich, CT, 185-206, 1997.

7. Getzenberg, R.H. Telomerase, Aging and Cancer. AUA News, 2(4):10, 1997.

8. Getzenberg, R.H. Vitamin D and Normal Prostate Growth and Differentiation. Nutrition Report, 15(4):25,32, 1997.

9. Uskokovic, M.R., Trump, D.L., Getzenberg, R.H., and Johnson, C.S. Anticancer Activity of Vitamin D Analogs. In: Holick, M.(ed) Vitamin D Physiology, Molecular Biology, and Chemical Application, Humana Press, Totowa, NJ, in press.

10. Konety, B.R., Johnson, C.S., Trump, D.L., Getzenberg, R.H. Vitamin D in the Prevention and Treatment of Prostate Cancer. Seminars in Urologic Oncology, 17:77-84, 1999.

11. Getzenberg, R.H., Reviewer - Unweaving the Rainbow: Science, Delusion, and the Appetite for Wonder, Author, Richard Dawkins. Oncology Times, 1999.

12. Getzenberg, R.H. The Nuclear Matrix and Cytoskeleton. The Role of the Nuclear Matrix and Cytoskeleton in Cancer, In: Chung, L. W. K., Isaacs, W. B. and Simons, J. W. (eds) Prostate Cancer: Biology, Genetics, and the New Therapeutics. Humana Press, Totowa, NJ, 2000.

13. Lokeshwar, V.B. and Getzenberg, R.H. Voided Urine Markers. Lerner, S.P., Schoenberg, M., Sternberg, C. (Eds): Textbook of Bladder Cancer. London: T& F-Informa, 2005 (in preparation)