Dr. Shawn Lupold Laboratory

Shawn E Lupold, Ph.D. 
slupold1@jhmi.edu 
Johns Hopkins School of Medicine 
600 N Wolfe St, Park 209 Baltimore, MD 21287

Select Publications

-see pubmed for a complete list of publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=lupold+sE

Select Publications 

Peskoe SB, Barber J, Zheng Q, Meeker, AK, De Marzo AM, Platz EA, and Lupold SE.  Differential long-term stability of microRNAs in 12-20 year old archived formalin-fixed paraffin-embedded tissues. BMC Cancer. 2017 Jan 6;17(1):32. PMCID: PMC5219687
https://www.ncbi.nlm.nih.gov/pubmed/28061773

Kumar B, Khaleghzadegan S, Mears B, Hatano K, Kudrolli TA, Chowdhury WH, Yeater D, Ewing CM, Luo J, Isaacs WB, Marchionni L, and Lupold SE.  Identification of miR-30b-3p and miR-30d-5p as direct regulators of Androgen Receptor Signaling in Prostate Cancer by complementary functional microRNA library screening.  Oncotarget. 2016 Nov 8;7(45):72593-72607. PMCID: Pending
https://www.ncbi.nlm.nih.gov/pubmed/27683042

Mukherjee A, Kumar B, Hatano K, Russell LM, Trock BJ, Searson PC, Meeker AK, Pomper MG and Lupold SE. Development and application of a novel model system to study ‘active’ and ‘passive’ tumor targeting.  Mol Cancer Ther. 2016 Oct;15(10):2541-2550. PMCID: PMC5050124http://www.ncbi.nlm.nih.gov/pubmed/27486224

Kumar B and Lupold SE. MicroRNA Expression and Function in Prostate Cancer: A Review of Current Knowledge and Opportunities for Discovery. Asian J Androl. Asian J Androl. 2016 Jul-Aug;18(4):559-67. PMCID: PMC4955179
http://www.ncbi.nlm.nih.gov/pubmed/27056344

Ni X, Zhang Y, Zennami K, Castanares M, Mukherjee A, Raval RR, Zhou H, DeWeese TL, and Lupold SE. Systemic administration and targeted radiosensitization via chemically synthetic aptamer-siRNA chimeras in human tumor xenografts. Mol Cancer Ther. 2015 Dec;14(12):2797-804. PMCID: PMC4674319
http://www.ncbi.nlm.nih.gov/pubmed/26438155

Hatano K, Kumar B, Zhang Y, Coulter JB, Hedayati M, Mears B, Ni X, Kudrolli TA, Chowdhury WH, Rodriguez R, DeWeese TL, and Lupold SE.  A functional screen identifies miRNAs that inhibit DNA repair and sensitize prostate cancer cells to ionizing radiation.  Nucleic Acids Res 2015 Apr 30;43(8):4075-86.  PMCID:  PMC4417178
http://www.ncbi.nlm.nih.gov/pubmed/25845598

Zheng Q, Peskoe SB, Ribas S, Rafiqi F, Kudrolli T, Meeker AK, De Marzo AM, Platz EA, and Lupold Se.  Investigation of miR-21, miR-141, and miR-221 expression levels in prostate adenocarcinoma for associated risk of recurrence after radical prostatectomy. Prostate. 2014 Dec; 74(16):1655-62. PMID: 25252191
http://www.ncbi.nlm.nih.gov/pubmed/25252191

Wu P, Sokoll LJ, Kudrolli TA, Chowdhury WH, Ma R, Liu MM, Rodriguez R, Lupold SE. A novel approach for detecting viable and tissue-specific circulating tumor cells through an adenovirus-based reporter vector. Prostate. 2014 Sep;74(13):1286-96. PMCID: PMC4130793
http://www.ncbi.nlm.nih.gov/pubmed/25065656

Castanares MA, Mukherjee A, Chowdhury WH, Liu M, Chen Y, Mease R, Wang Y, Rodriguez R, Lupold SE*, and Pomper MG*.  The development and evaluation of Prostate Specific Membrane Antigen as a novel imaging reporter. J Nucl. Med 2014.  May;55(5):805-11. PMCID: PMC4074907 (*equal contribution)
http://www.ncbi.nlm.nih.gov/pubmed/24700883

Mukherjee A, Darlington T, Baldwin R, Holz C, Olsen S, Kulkarni P, DeWeese TL, Getzenberg RH, Ivkov R and Lupold SE.  Development and screening of a series of antibody-conjugated and silica coated ironoxide nanoparticles for targeting the Prostate Specific Membrane Antigen.  ChemMedChem. 2014 Jul;9(7):1356-60. PMCID: PMC4082462
http://www.ncbi.nlm.nih.gov/pubmed/24591351

Mukherjee A, Castanares M, Hedayati M, Wabler M, Trock B, Kulkarni P, Rodriguez R, Getzenberg RH, DeWeese TL, Ivkov R*, and Lupold SE*. Monitoring nanoparticle mediated cellular hyperthermia with a high sensitivity biosensor.  Nanomedicine (Lond). 2014 Feb 18. [Epub ahead of print]. (*equal contribution)
http://www.ncbi.nlm.nih.gov/pubmed/24547783

Lupold SE, Johnson T, Chowdhury WH, and Rodriguez R.  A real time Metridia Luciferase based non-invasive reporter assay of mammalian cell viability and cytotoxicity via the β-actin promoter and enhancer.  PLoS ONE 7(5): e36535, 2012. PMCID: PMC3348918
http://www.ncbi.nlm.nih.gov/pubmed/22590558

Ribas J, Ni X, Castanares M, Liu M, Rodriguez R, Mendell JT, and Lupold SE. A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts.  Nucleic Acids Res. 2012 Aug 1;40(14):6821-33. PMCID: PMC3413119
http://www.ncbi.nlm.nih.gov/pubmed/22505577

Ni X, Castanares M, Mukherjee A, and Lupold SE.  Nucleic Acid Aptamer: clinical applications and promising new horizons.  Cur Med Chem. 18(27), 4206-4214, 2011. PMCID: PMC3104752
http://www.ncbi.nlm.nih.gov/pubmed/21838685

Ni X, Zhang Y, Ribas J, Chowdhury WH, Castanares M, Zhang Z, Laiho M, DeWeese TL, Lupold SE. Prostate-targeted radiosensitization via aptamer-shRNA chimeras in human tumor xenografts.  Journal of Clinical Investigation.  J Clin Invest. 2011 Jun 1; 121(6):2383-90. PMCID: PMC3104752
http://www.ncbi.nlm.nih.gov/pubmed/21555850

Wu P, Kudrolli TA, Chowdhury WH, Minzhi ML, Rodriguez R, and Lupold SE.  Adenovirus Targeting to Prostate-specific Membrane Antigen through Virus displayed Semi-random Peptide Library Screening.  Cancer Res. [Priority Report] Cancer Res. 2010 Dec 1; 70(23):9549-53. PMCID: PMC2995819
http://www.ncbi.nlm.nih.gov/pubmed/20670952

Ribas J and Lupold SE.  The transcriptional regulation of miR-21, its multiple transcripts, and their implication in prostate cancer. Cell Cycle; 9(5), 923-9, 2010. PMCID: PMC3462654
http://www.ncbi.nlm.nih.gov/pubmed/20160498

Ribas J, Ni X, Haffner M, Wentzel EA, Salmasi1 AH, Chowdhury WE, Kudrolli TA, Yegnasubramanian A, Luo J, Rodriguez T, Mendell JT, Lupold SE.  miR-21:  An androgen receptor regulated microRNA which promotes hormone dependent and independent prostate cancer growth.  Cancer Research. [Priority Report]  69(18): 7165-9, 2009. PMCID: PMC2861586.   
http://www.ncbi.nlm.nih.gov/pubmed/19738047

Lupold SE., Kudrolli T., Chowdhury W., Wu P, and Rodriguez R. “A Novel Method for Generating and Screening Peptides and Libraries Displayed on Adenovirus Fiber” Nucl. Acids Res. 35(20):e138, 1-10, 2007 . PMCID: PMC2175307
http://www.ncbi.nlm.nih.gov/pubmed/17965092
Lupold SE. and Rodriguez R.  Disulfide-Constrained Peptides that Bind to the Extracellular Portion of the Prostate Specific Membrane Antigen.  Mol Cancer Ther. 3(5):597-603, 2004
http://www.ncbi.nlm.nih.gov/pubmed/15141017

Lupold SE., Hicke B.J., Lin Y., Coffey DS. Identification and characterization of nuclease-stabilized RNA molecules that bind human prostate cancer cells via the prostate-specific membrane antigen. Cancer Research. 62(14):4029-33, 2002.
http://www.ncbi.nlm.nih.gov/pubmed/12124337


Book Chapters
Byun Y, Mease RC, Lupold SE, Pomper MG. Recent Development of Diagnostic and Therapeutic Agents Targeting Glutamate Carboxypeptidase II (GCPII), Chapter 36, In Drug Design of Zinc-Enzyme Inhibitors: Functional, Structural, and Disease Applications.  Wiley, 2009
http://www.wiley.com/WileyCDA/WileyTitle/productCd-0470275006.html

Ribas J and Lupold SE.  Role of miR-21, and androgen-regulated microRNA, in prostate cancer, In Androgen Responsive Genes in Prostate Cancer, Springer, 2012Chapter 18, in Androgen-Responsive Genes in Prostate Cancer.  Regulation, Function and Clinical Applications.  Springer, 2013
http://www.springer.com/biomed/cancer/book/978-1-4614-6181-4

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