The life cycle of invasive species is directly analogous to the study of cancer metastasis [see Figure]. Cancer must grow in a primary site, extravasate and survive in the circulation to then intravasate at a target organ (invasive species survival in trans- port). Cancer cells often lay dormant at their metastatic site for a long period of time (lag period) before proliferating (invasive spread). Proliferation in the new site has an impact on the target organ microenvironment (ecological impact) and eventually the human host (biosphere impact).
Chen KW, Pienta KJ. Modeling invasion of metastasizing cancer cells to bone marrow utilizing ecological principles. Theor Biol Med Model. 2011 Oct 3;8:36
A large proportion of solid tumor metastases are bone metastases, known to usurp HSC hom- ing pathways to establish footholds in the bone marrow. Recent evidence suggests that tumor cells target and parasitize the HSC niche during metastasis just as invasive species do in the environment. Successful metastatic cancer cells grow in a primary site, emigrate out from that site, survive during migrate, immigrate into the new environment, and then naturalize and overtake / co-opt and / or cooperate with the host species to form a new tumor ecosystem
Prostate cancer as an invasive species
Pienta KJ, Loberg R. The “emigration, migration, and immigration”of prostate cancer. Clin Prostate Cancer. 2005 Jun;4(1):24-30.