The James Buchanan Brady Urological Institute
 
 
 

Dr. Kenneth Pienta LABORATORY

Publications

Identification of Targetable FGFR Gene Fusions in Diverse Cancers.

Wu YM, Su F, Kalyana-Sundaram S, Khazanov N, Ateeq B, Cao X, Lonigro RJ, Vats P, Wang R, Lin SF, Cheng AJ, Kunju LP, Siddiqui J, Tomlins SA, Wyngaard P, Sadis S, Roychowdhury S, Hussain M, Feng FY, Zalupski MM, Talpaz M, Pienta KJ, Rhodes DR, Robinson DR, Chinnaiyan AM. Cancer Discov. 2013 Apr 4. PMID: 23558953

The 19th Annual Prostate Cancer Foundation Scientific Retreat: Meeting Report.

Walia G, Pienta KJ, Simons JW, Soule HR. Cancer Res. 2013 Mar 27. [Epub ahead of print] PMID: 23536559

Cancer stem cells and their role in metastasis. Shiozawa Y, Nie B, Pienta KJ, Morgan TM, Taichman RS. Pharmacol Ther. 2013 May;138(2):285-93. PMID: 23384596

Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Robinson DR, Wu YM, Kalyana-Sundaram S, Cao X, Lonigro RJ, Sung YS, Chen CL, Zhang L, Wang R, Su F, Iyer MK, Roychowdhury S, Siddiqui J, Pienta KJ, Kunju LP, Talpaz M, Mosquera JM, Singer S, Schuetze SM, Antonescu CR, Chinnaiyan AM. Nat Genet. 2013 Feb;45(2):180-5. PMID: 23313952

New and emerging therapies for bone metastases in genitourinary cancers.
Saylor PJ, Armstrong AJ, Fizazi K, Freedland S, Saad F, Smith MR, Tombal B, Pienta K. Eur Urol. 2013 Feb;63(2):309-20. PMID: 23201471 Definition of molecular determinants of prostate cancer cell bone extravasation. Barthel SR, Hays DL, Yazawa EM, Opperman M, Walley KC, Nimrichter L, Burdick MM, Gillard BM, Moser MT, Pantel K, Foster BA, Pienta KJ, Dimitroff CJ. Cancer Res. 2013 Jan 15;73(2):942-52. PMID: 23149920

Role of transcriptional corepressor CtBP1 in prostate cancer progression.

Wang R, Asangani IA, Chakravarthi BV, Ateeq B, Lonigro RJ, Cao Q, Mani RS, Camacho DF, McGregor N, Schumann TE, Jing X, Menawat R, Tomlins SA, Zheng H, Otte AP, Mehra R, Siddiqui J, Dhanasekaran SM, Nyati MK, Pienta KJ, Palanisamy N, Kunju LP, Rubin MA, Chinnaiyan AM, Varambally S. Neoplasia. 2012 Oct;14(10):905-14.

Pienta KJ, Machiels JP, Schrijvers D, Alekseev B, Shkolnik M, Crabb SJ, Li S, Seetharam S, Puchalski TA, Takimoto C, Elsayed Y, Dawkins F, de Bono JS.

 Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer.  Invest New Drugs. 2012 Aug 21

Jung Y, Shiozawa Y, Wang J, McGregor N, Dai J, Park SI, Berry JE, Havens AM, Joseph J, Kim JK, Patel L, Carmeliet P, Daignault S, Keller ET, McCauley LK, Pienta KJ, Taichman RS.   

Prevalence of prostate cancer metastases after intravenous inoculation provides clues into the molecular basis of dormancy in the bone marrow microenvironment.
 Neoplasia. 2012 May;14(5):429-39.

Grasso CS, Wu YM, Robinson DR, Cao X, Dhanasekaran SM, Khan AP, Quist MJ, Jing X, Lonigro RJ, Brenner JC, Asangani IA, Ateeq B, Chun SY, Siddiqui J, Sam L, Anstett M, Mehra R, Prensner JR, Palanisamy N, Ryslik GA, Vandin F, Raphael BJ, Kunju LP, Rhodes DR, Pienta KJ, Chinnaiyan AM, Tomlins SA.  

The mutational landscape of lethal castration-resistant prostate cancer.  Nature. 2012 Jul 12;487(7406):239-43.

Park SI, Liao J, Berry JE, Li X, Koh AJ, Michalski ME, Eber MR, Soki FN, Sadler D, Sud S, Tisdelle S, Daignault SD, Nemeth JA, Snyder LA, Wronski TJ, Pienta KJ, McCauley LK.

Cyclophosphamide creates a receptive microenvironment for prostate cancer skeletal metastasis.
 Cancer Res. 2012 May 15;72(10):2522 -32.

Mishra A, Wang J, Shiozawa Y, McGee S, Kim J, Jung Y, Joseph J, Berry JE, Havens A,Pienta KJ, Taichman RS. 

Hypoxia stabilizes GAS6/AXl signaling in metastatic prostate cancer.
 Mol Cancer Res. 2012 Apr 19.

Pienta KJ, Gelato MC, Lichtenstein MJ.

Forging the Association for Clinical and Translational Science (ACTS). Clin Transl Sci. 2012 Apr;5(2):117-8.



Pienta KJ, Camacho DF. Disrupting the networks of cancer.
 Clin Cancer Res. 2012 Mar 22. [Epub ahead of print]



Pedersen EA, Shiozawa Y, Pienta KJ, Taichman RS.  The prostate cancer bone marrow niche: more than just ‘fertile soil’
.  Asian J Androl. 2012 Feb 27.

Joseph J, Shiozawa Y, Jung Y, Kim JK, Pedersen E, Mishra A, Zalucha JL, Wang J, Keller ET, Pienta KJ, Taichman RS.  

Disseminated prostate cancer cells can instruct hematopoietic stem and progenitor cells to regulate bone phenotype.
 Mol Cancer Res. 2012 Mar;10(3):282-92. Epub 2012 Jan 12.

Elbez R, McNaughton BH, Patel L, Pienta KJ, Kopelman R. 

Nanoparticle induced cell magneto-rotation: monitoring morphology, stress and drug sensitivity of a suspended single cancer cell. PLoS One. 2011;6(12):e28475.

Roca H, Craig MJ, Ying C, Varsos ZS, Czarnieski P, Alva AS, Hernandez J, Fuller D, Daignault S, Healy PN, Pienta KJ.  

IL-4 induces proliferation in prostate cancer PC3 cells under nutrient-depletion stress through the activation of the JNK-pathway and survivin upregulation.
 J Cell Biochem. 2011 Dec 15

Roychowdhury S, Iyer MK, Robinson DR, Lonigro RJ, Wu YM, Cao X, Kalyana-Sundaram S, Sam L, Balbin OA, Quist MJ, Barrette T, Everett J, Siddiqui J, Kunju LP, Navone N, Araujo JC, Troncoso P, Logothetis CJ, Innis JW, Smith DC, Lao CD, Kim SY, Roberts JS, Gruber SB, Pienta KJ, Talpaz M, Chinnaiyan AM.  

Personalized oncology through integrative high-throughput sequencing: a pilot study.
 Sci Transl Med. 2011 Nov 30;3(111):111ra121.

Lonigro RJ, Grasso CS, Robinson DR, Jing X, Wu YM, Cao X, Quist MJ, Tomlins SA,Pienta KJ, Chinnaiyan AM. Detection of somatic copy number alterations in cancer using targeted exome capture sequencing. Neoplasia. 2011 Nov;13(11):1019-25.

Roca H, Craig MJ, Ying C, Varsos ZS, Czarnieski P, Alva AS, Hernandez J, Fuller D, Daignault S, Healy PN, Pienta KJ.  

IL-4 induces proliferation in prostate cancer PC3 cells under nutrient-depletion stress through the activation of the JNK-pathway and survivin upregulation.
 J Cell Biochem. 2011 Dec 15. doi: 10.1002/jcb.24025. [Epub ahead of print]

Elbez R, McNaughton BH, Patel L, Pienta KJ, Kopelman R. 

Nanoparticle induced cell magneto-rotation: monitoring morphology, stress and drug sensitivity of a suspended single cancer cell.
 PLoS One. 2011;6(12):e28475. Epub 2011 Dec 13

Hsiao AY, Tung YC, Kuo CH, Mosadegh B, Bedenis R, Pienta KJ, Takayama S. 

Micro-ring structures stabilize microdroplets to enable long term spheroid culture in 384 hanging drop array plates.
 Biomed Microdevices. 2011 Nov 5

Patel LR, Camacho DF, Shiozawa Y, Pienta KJ, Taichman RS. 

Mechanisms of cancer cell metastasis to the bone: a multistep process.  Future Oncol. 2011 Nov;7(11):1285-97.
Dwyer-White M, Doshi A, Hill M, Pienta KJ. 

Centralized Research Recruitment-Evolving a Local Clinical Research Recruitment Web Application to Better Meet User Needs.
 Clin Transl Sci. 2011 Oct;4(5):363-368. 

Selker HP, Pienta KJ. The importance of proposed changes in the “common rule” for -clinical and translational researchers. Clin Transl Sci. 2011 Oct;4(5):312-3. 

Chen KW, Pienta KJ. 


Modeling invasion of metastasizing cancer cells to bone marrow utilizing ecological principles.
 Theor Biol Med Model. 2011 Oct 3;8:36.

 

Pienta KJ, Spork AL, Scheske   The Clinical and Translational Science Awards (CTSAs) Are Transforming the Way Academic Medical Institutions Approach Translational Research: The University of Michigan Experience J.  Clin Transl Sci. 2011 Aug;4(4):233-5.http://www.ncbi.nlm.nih.gov/pubmed/21884508

Mishra A, Shiozawa Y, Pienta KJ, Taichman RS.   Homing of Cancer Cells to the Bone.  Cancer Microenviron. 2011 Aug 9. http://www.ncbi.nlm.nih.gov/pubmed/21826451

Shiozawa Y, Pienta KJ, Taichman RS. Hematopoietic stem cell niche is a potential therapeutic target for bone metastatic tumors. Clin Cancer Res. 2011 Sep 1;17(17):5553-8. Epub 2011 Jun 15. http://www.ncbi.nlm.nih.gov/pubmed/21676926


Brenner JC, Ateeq B, Li Y, Yocum AK, Cao Q, Asangani IA, Patel S, Wang X, Liang H, Yu J, Palanisamy N, Siddiqui J, Yan W, Cao X, Mehra R, Sabolch A, Basrur V, Lonigro RJ, Yang J, Tomlins SA, Maher CA, Elenitoba-Johnson KS, Hussain M, Navone NM, Pienta KJ, Varambally S, Feng FY, Chinnaiyan AM. Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell. 2011 May 17;19(5):664-78. http://www.ncbi.nlm.nih.gov/pubmed/21575865


Mehra R, Kumar-Sinha C, Shankar S, Lonigro RJ, Jing X, Philips NE, Siddiqui J, Han B, Cao X, Smith DC, Shah RB, Chinnaiyan AM, Pienta KJ. Characterization of bone metastases from rapid autopsies of prostate cancer patients.  Clin Cancer Res. 2011 Jun 15;17(12):3924-32. Epub 2011 May 9. http://www.ncbi.nlm.nih.gov/pubmed/21555375


Shiozawa Y, Pedersen EA, Havens AM, Jung Y, Mishra A, Joseph J, Kim JK, Patel LR, Ying C, Ziegler AM, Pienta MJ, Song J, Wang J, Loberg RD, Krebsbach PH, Pienta KJ, Taichman RS. Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow.  J Clin Invest. 2011 Apr 1;121(4):1298-312. doi: 10.1172/JCI43414. Epub 2011 Mar 23. http://www.ncbi.nlm.nih.gov/pubmed/21436587


Li X, Liao J, Park SI, Koh AJ, Sadler WD, Pienta KJ, Rosol TJ, McCauley LK. Drugs which inhibit osteoclast function suppress tumor growth through calcium reduction in bone. Bone. 2011 Jun 1;48(6):1354-61. Epub 2011 Mar 17.http://www.ncbi.nlm.nih.gov/pubmed/21419883


Ateeq B, Tomlins SA, Laxman B, Asangani IA, Cao Q, Cao X, Li Y, Wang X, Feng FY, Pienta KJ, Varambally S, Chinnaiyan AM. Therapeutic targeting of SPINK1-positive prostate cancer. Sci Transl Med. 2011 Mar 2;3(72):72ra17.http://www.ncbi.nlm.nih.gov/pubmed/21368222


Zhang J, Sud S, Mizutani K, Gyetko MR, Pienta KJ.  Activation of urokinase plasminogen activator and its receptor axis is essential for macrophage infiltration in a prostate cancer mouse model.  Neoplasia. 2011 Jan;13(1):23-30.http://www.ncbi.nlm.nih.gov/pubmed/21245937


Pienta KJ.  Successfully accelerating translational research at an academic medical center: the University of Michigan-Coulter translational research partnership program.  Clin Transl Sci. 2010 Dec;3(6):316-8. http://www.ncbi.nlm.nih.gov/pubmed/21167009



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