Calculate

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PSA: Please select one -- ‹10 10-20 >20

Gleason Score: Please select one -- 3+3 3+4 4+3 4+4 4+5 5+4 5+5

Clinical Stage/Rectal Exam:
Please select one -- Normal Abnormal 1 Abnormal 2
Note*:
Abnormal 1 : do not extend beyond prostate
Abnormal 2 : with extension beyond the prostate

Imaging:
Please select one -- Negative Lymph node/other site involvment

Show Value

Very Low Risk Prostate Cancer

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• PSA <10
• Gleason 3+3=6 and less than 2cores
• Clinical Exam: normal

Management Options

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• Active Surveillance
• Open Radical Prostatectomy
• Robotic Radical Prostatectomy
• Radiation Therapy
• Watchful Waiting

Clinical Trials

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• J1408 A phase 2 Study of Bicalutamide Plus Finasteride in Men with MRI Detectable Prostate Nodules Undergoing Active Surveillance

Resources

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Low Risk of Prostate Cancer

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• PSA 0-10
• Gleason 3+3=6 and more than 2cores
• Clinical Exam: normal or 1/2 abnormality , one side only

Management Options

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These men have a very low risk of dying from prostate cancer and generally do well with most forms of therapy. This is the most common form of prostate cancer.

• Active Surveillance
• Open Radical Prostatectomy
• Robotic Radical Prostatectomy
• Radiation Therapy
• Watchful Waiting

Clinical Trials

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• J1408 A phase 2 Study of Bicalutamide Plus Finasteride in Men with MRI Detectable Prostate Nodules Undergoing Active Surveillance
• Hypofractionated Adaptive Image-Guided Radiation Therapy for Localized Adenocarcinoma of the Prostate

Resources

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Intermediate Risk Prostate Cancer

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• PSA 10-20
• Gleason 3+4 or 4+3
• Clinical Exam: Abnormality that does not extend beyond the boundary of the prostate

Management Options

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• Open Radical Prostatectomy
• Robotic Radical Prostatectomy
• Radiation Therapy
• Watchful Waiting

Clinical Trials

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• A study of allogeneic human bone marrow derived mesenchymal stem cells in localized prostate cancer
• Hypofractionated Adaptive Image-Guided Radiation Therapy for Localized Adenocarcinoma of the Prostate

Resources

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High Risk Prostate Cancer

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• PSA >20
• Gleason 4+4 or 4+5, more than 5 cores
• Clinical Exam: Abnormality that extends beyound the prostate with no fixation

Management Options

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These men have a much higher risk of recurrence with surgery or radiation or surveillance, and often benefit from more aggressive combination approaches.

• Open Radical Prostatectomy
• Robotic Radical Prostatectomy
• Radiation Therapy
and 2- 3 years of hormonal suppresion
• Watchful Waiting

Clinical Trials

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• A parmacodynamic pre-surgical study of hedgehog pathway inhibition with LDE225 in men with high-risk localized prostate cancer

• Target: Hedgehog Pathway New Trial Opens for Men with High-Risk Prostate Cancer
• Salvage Radiation Therapy and Enzalutamide: A Winning Combination?

Resources

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Very High Risk Prostate Cancer

 

• Gleason 5+4 or 4+5
• Gleason 4+4 or 4+5 and more than 4 cores
• Clinical Exam

Management Options

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• Open Radical Prostatectomy
• Robotic Radical Prostatectomy
• Radiation Therapy
• Watchful Waiting

Clinical Trials

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• A parmacodynamic pre-surgical study of hedgehog pathway inhibition with LDE225 in men with high-risk localized prostate cancer

Resources

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Metastatic

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• PSA
• Gleason
• Clinical Exam

Management Options

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• Hormone Therapy
• Chemotherapy
• Radium 223
• Immuntherapy

Clinical Trials

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• NCT02489357: Pembrolizumab and Cryosurgery in Treating Patients with Newly Diagnosed, Oligo-metastatic Prostate Cancer

Resources

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• New study proves early treatment with both chemotherapy and hormonal therapy has a major impact
• New Test Can Determine Whether Expensive Treatments Will Work In Metastatic Cancer