Adrenal Cancer, Bladder Cancer, Image-Guided Radiation Therapy, Intensity-Modulated Radiation Therapy (IMRT), Metastatic Bone Disease, Metastatic Disease, Oligometastatic Disease, Penile Cancer, Prostate Cancer, Radiation Oncology, Stereotactic Body Radiation Therapy, Testicular Cancer, Urethral Cancer
Radiosensitizers; Genetically engineered mouse models of disease; Epithelial Plasticity (Epithelial-Mesenchymal Transition and Mesenchymal-Epithelial Transition)
Dr. Tran's research focuses on the improvement of clinical radiotherapy for the treatment of adrenal, bladder, penile, prostate, testicular and urethral cancer. To learn how tumors grow and why some cancers are resistant to treatment, he studies the transitions of epithelial and mesenchymal cellular states in transgenic mouse models.
Additionally, Dr. Tran is working with colleagues from top-ranked institutions nationwide to establish a National Radiation Oncology Registry. The purpose of the registry is to improve the care of cancer patients by capturing and studying information about cancer treatments and outcomes.
Dr. Phuoc T. Tran is an associate professor of radiation oncology and molecular radiation sciences, oncology and urology at the Johns Hopkins School of Medicine.
Dr. Tran is the Clinical Director of Radiation Oncology at the Sidney Kimmel Comprehensive Cancer Center and treats patients with cancers of the genitourinary system and uses stereotactic radiation techniques (such as SRS and SBRT/SABR) for the treatment of patients with oligometastatic disease. His research focuses on the improvement of clinical radiotherapy for the treatment of adrenal, bladder, penile, prostate, testicular and urethral cancer as well as patients with oligometastatic disease.
Dr. Tran and his laboratory focus their studies on the transitions between epithelial and mesenchymal cellular states and the implications of these transitions for tumorigenesis, cancer treatment resistance and radiation-induced fibrosis. Their research utilizes a variety of inducible transgenic mouse models and non-invasive rodent imaging.
One of these transitions, known as epithelial-mesenchymal transition (EMT), is a conserved developmental program that when inappropriately activated in post-natal life has been associated with organ fibrosis, tumorigenesis and metastasis. A major focus of the laboratory is the use of inducible mouse models to simulate molecularly targeted therapies for malignancies and radiation induced late effects. Another focus of the laboratory is the study of novel targeted agents as tumor selective radiosensitizers to increase the therapeutic ratio of clinical radiotherapy.
The Tran lab is committed to translating discoveries from the laboratory bench into novel cancer prevention, diagnostic and treatment approaches that can be tested in the clinic.
National Cancer Institute 1R01CA166348-01A1, 2013-2018
Sidney Kimmel Translational Scholar Award. 2013-2015
Patrick C. Walsh Prostate Cancer Research Fund Award, 2013-2014
Alpha Omega Alpha Honor Medical Society Alumni Award, Oregon Health & Sciences University Chapter, 2013
Oregon Health & Sciences University School of Medicine Alumni Association Early Career Achievement Award, 2013
American Cancer Society Research Scholar, 2012-2016
Uniting Against Lung Cancer Award, 2012-2014
Included among Top Doctors by Baltimore Magazine, 2012
Association of Residents in Radiation Oncology (ARRO) Educator of The Year, 2012
DoD Prostate Cancer Physician Research Training Award, 2011-2016
The Phyllis and Brian L. Harvey Scholar - Patrick C. Walsh Prostate Cancer Research Fund Award, 2011-2013
ASTRO Junior Faculty Career Research Training Award, 2009-2011
Parker B. Francis Fellow, 2008-2011
Radiological Society of North America Research Fellow, 2008
Henry S. Kaplan Research Fellow, 2007
Malcolm A. Bagshaw Award, 2007
ASCO/AACR Methods in Clinical Cancer Research Workshop Scholarship, 2007
Radiological Society of North America Research Resident, 2006
Radiological Society of North America Roentgen Resident Research Award, 2006
OHSU Deans Medical Student Research Award, 2003
OHSU Molecular Hematology Research Training Fellow, 1998-2001
OHSU Laurel Merit MD/PhD Scholar, 1996-2003
Graduated magna cum laude from University of California, San Diego, 1996
University of California Regents Scholar, 1995-1996
John Muir College Caledonian Honor Society, University of California, San Diego, 1995