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the patrick c. walsh prostate cancer research fund
Developing the Brady Genomics Portal
“The Brady Urological Institute, in conjunction with the Department of Pathology, has an unrivaled biorepository of prostate cancer,” says pathologist Alex Baras, M.D., Ph.D. But this amazing library of prostate cancer samples and data could be even better, he believes. Baras, with pathologist Tamara Lotan, M.D., and urologist Ashley Ross, M.D., Ph.D., plans “to leverage this unique resource to develop the Brady Genomics Portal,” taking the understanding of prostate cancer to a new level with new molecular and genetic characterizations of prostate cancer.
In work funded by the Patrick C. Walsh Prostate Cancer Research Fund, the investigators will examine the Natural History Cohort, “a data set that includes 356 men with intermediate- or high-risk prostate cancer,” Baras explains. The team will augment tissue samples from these tumors, which have had DNA and RNA extracted, with genomic studies characterizing gene mutations and copy number alterations. The team will integrate clinical and pathologic findings with the latest molecular information; their comprehensive results will be made available to Brady researchers and updated regularly. “We hope this will prove to be an invaluable and renewable resource for the Brady for years to come.”