prostate cancer discovery

 

 

Read About the Research You have Helped Make Possible.

The Patrick C. Walsh Prostate Cancer Research Fund

New Drug Selectively Kills Prostate Cancer Cells, and Works Even Better When Combined With Radiation

 

Venu Raman, Ph.D., and colleagues have identified a gene called DDX3. You probably haven’t heard of it, but if it is as promising as Raman believes, you will be hearing more about it someday soon. Raman, who holds a joint appointment in the Department of Radiology and Radiological Science and in the Department of Oncology, is intrigued by DDX3 because “it is essential for the maintenance of man y high-grade tumors, including those of prostate cancer,” he says. When he and colleagues stained cancer tissue samples, they found that “35 percent of tumors with a Gleason score of more than 7 have an increased expression of DDX3.” And this is important because “w e have designed a drug, which we call RK-33, that neutralizes the function of DDX3.” The result? Only the cancer cells die , and the normal cells are unharmed.

 

“We have designed a drug,” called RK-33, that kills cancer cells, but leaves normal cells unharmed.

 

Even more exciting, says Raman, The Carolyn and Bill Stutt Scholar, is that when RK-33 is combined with radiation, “it produces a synergistic cell death effect on cancer cells . We are confident that the use of DDX3 as a biomarker, to determine which cancers should be treated with RK-33 and radiation, will not only significantly reduce the tumor burden, but also reduce many side effects of conventional treatment.” When mice were treated with RK-33, they did not demons trate any evidence of toxicity, which suggests that “we can expedite the use of RK-33 into the clinical setting.”

© The Johns Hopkins University, The Johns Hopkins Hospital, and Johns Hopkins Health System. All rights reserved. Disclaimer
Email: webmaster@urology.jhu.edu | 600 North Wolfe Street, Baltimore, Maryland 21287

urology second opinion urology second opinion