Testosterone Plus Radiation Equals Better Cancer Control
DeWeese and Yegnasubramanian: Giving testosterone after a period
of hormonal therapy is "a radicalnotion that... would represent a
paradigm shift for treatment of high-risk prostate cancer. "An unusual observation by Hopkins scientists about how testosterone affects prostate cancer cells may lead to more effective radiation therapy in men with high-risk disease.
"These data led us to consider," DeWeese adds, "that testosterone stimulation after an initial period of testosterone deprivation, when appropriately timed with radiation therapy, might lead to particularly effective control of high-risk prostate cancer – a radical notion that, if proven, would represent a paradigm shift for treatment of high-risk prostate cancer."