Next Step After the HOXB13 Discovery: A Mouse Model of Familial Prostate Cancer
The exciting discovery (see story) by William Isaacs, Ph.D., and colleagues of a major susceptibility gene for prostate cancer, HOXB13, was Step One. Step Two: A mouse model. "Mouse models have proved invaluable in their ability to provide unprecedented insight into the mechanics of human cancer genes," says Isaacs. "We hypothesize that when a mutated version of HOXB13 is expressed in the mouse prostate, either by itself or in conjunction with an established prostate oncogene, it will promote or accelerate the development of prostate cancer in mice.