July 20, 2008


Mark L. Gonzalgo, M.D., Ph.D.

Assistant Professor of Urology and Oncology
Johns Hopkins Medical Institutions

Director, Urologic Oncology Fellowship
Johns Hopkins Medical Institutions


Email:gonzalgo@jhmi.edu

    Free Access to abstracts at PubMed

  
PEER-REVIEWED SCIENTIFIC ARTICLES:
  1. Bastian, P.J., Gonzalgo M.L., Aronson, W.J., Terris, M.K., Kane, C.J., Amling, C.L., Presti, J.C., Mangold, L.A., Humphreys, E., Epstein, J.I., Partin, A.W., and Freedland, S.J. Clinical and pathological outcome after radical prostatectomy for prostate cancer with a preoperative Gleason sum 8 to 10. Cancer,107:1265-1272, 2006.

  2. Makarov, D.V., Bagga, H., and Gonzalgo M.L. Genitourinary myiasis (maggot infestation). Urology, in press.


  3. Gonzalgo M.L., Su, L.M., and Basaria, S. Adrenal myelolipoma. Endocr Prac.,12: 109, 2006.

  4. Gonzalgo M.L., Bastian, P.J., Mangold, L.A., Epstein, J.I., Walsh, P.C., and Partin, A.W. Relationship between primary Gleason pattern on prostate needle biopsy and clinicopathological outcomes among men with Gleason 7 adenocarcinoma of the prostate. Urology, 67: 115-119, 2006.

  5. Krishnan, M., Park, J.M., Wang, D., Tseng, J.R., Gonzalgo M.L., Gambhir, S.S., and Wu, J.C. Effects of epigenetic modulation on reporter gene expression: implications for stem cell imaging. FASEB J, 10: 1-18, 2006.

  6. Gonzalgo M.L., Pavlovich, C.P., Trock, B.J., Link, R.E., Sullivan, W., and Su, L.M. Classification and trends of perioperative morbidities following laparoscopic radical prostatectomy. J Urol, 174: 135-139, 2005.

  7. Friedrich, M.G., Weisenberger, D.J., Cheng, J.C., Chandrasoma, S., Siegmund, K.D., Gonzalgo M.L., Toma, M.I., Huland, H., Yoo, C., Tsai, Y.C., Nichols, P.W., Bochner, B.H., Jones, P.A., and Liang, G. Detection of methylated apoptosis-associated genes in urine sediments of bladder cancer patients. Clin Cancer Res., 10: 7457-7465, 2004.

  8. Gonzalgo M.L., Yegnasubramanian, S., Yan, G., Rogers, C.G., Nelson, W.G., Nicol, T.L., and Pavlovich, C.P. Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysis. Clin Cancer Res., 10: 7276-7283, 2004.

  9. Varkarakis, I.M., Bhayani, S.B., Allaf, M.E., Inagaki, T., Gonzalgo M.L., and Jarrett, T.W. Laparoscopic-assisted nephrectomy with inferior vena cava tumor thrombectomy: preliminary results. Urology, 64: 925-929, 2004.

  10. Rogers, C.G., Yan, G., Zha, S., Gonzalgo M.L., Isaacs, W.B., Luo, J., De Marzo, A.M., Nelson, W.G., and Pavlovich, C.P. Prostate cancer detection on urinalysis for alpha methylacyl coenzyme a racemase protein. J Urol, 172: 1501-1503, 2004.

  11. Yegnasubramanian, S., Kowalski, J., Gonzalgo M.L., Zahurak, M., Piantadosi, S., Walsh, P.C., Bova, G.S., De Marzo, A.M., Isaacs, W.B., and Nelson, W.G. Hypermethylation of CpG islands in primary and metastatic human prostate cancer. Cancer Res., 64: 1975-1986, 2004.

  12. Gonzalgo M.L., Nakayama, M., Lee, S.M., De Marzo, A.M., and Nelson, W.G. Detection of GSTP1 methylation in prostatic secretions using combinatorial MSP analysis. Urology, 63: 414-418, 2004.

  13. Gonzalgo M.L., and Chan, D.Y. Endoscopic basket extraction of a urethral foreign body. Urology, 62: 352, 2003.
    14. Gonzalgo M.L., Pavlovich, C.P., Lee, S.M., and Nelson, W.G. Prostate cancer detection by GSTP1 methylation analysis of post-biopsy urine specimens. Clin Cancer Res., 9: 2673-2677, 2003.

  14. Gonzalgo M.L., Brotzman, M., Trock, B.J., Burnett, A.L., Geringer, A.L., and Jarow, J.P. Clinical efficacy of sildenafil citrate and predictors of long-term response. J Urol, 170: 503-506, 2003.

  15. Gonzalgo M.L., de Lacerda, D.A., De Marzo, A.M., and Chan, D.Y. Persistent purulent drainage from the glans penis: atypical presentation of pyoderma gangrenosum. J Urol, 169:1793-1794, 2003.

  16. Gonzalgo M.L. and Walsh, P.C. Balloon cuffing and management of the entrapped Foley catheter. Urology, 61:825-827, 2003.

  17. Gonzalgo M.L., Eisenberger, C.F., Lee, S.M., Trock, B.J., Marshall, F.F., Hortopan, S., Sidransky, D., and Schoenberg, M.P. Prognostic significance of preoperative molecular serum analysis in renal cancer. Clin Cancer Res, 8: 1400-1403, 2002.

  18. Bender, C.M., Gonzalgo M.L., Gonzales, F.A., Nguyen, C.T., Robertson, K.D., and Jones, P.A. The roles of cell division and gene transcription in the de novo methylation of CpG islands following demethylation by 5-Aza-2’-deoxycytidine. Mol Cell Biol, 19: 6690-6698, 1999.

  19. Tsutsumi, M., Tsai, Y.C., Gonzalgo M.L., Nichols, P.W., and Jones, P.A. Early acquisition of homozygous deletions of p16/p19 during squamous cell carcinogenesis and genetic mosaicism in bladder cancer. Oncogene, 17: 3021-3028, 1998.

  20. Gonzalgo M.L., Hayashida, T., Bender, C.M., Pao, M.M., Tsai, Y.C., Gonzales, F.A., Nguyen, H.D., Nguyen, T.T., and Jones, P.A. The role of DNA methylation in expression of the p19/p16 locus in human bladder cancer cell lines. Cancer Res, 58: 1245-1252, 1998.

  21. Gonzalgo M.L., Bender, C.M., You, E.H., Glendening, J.M., Flores, J.F., Walker, G.J., Hayward, N.K., Jones, P.A., and Fountain, J.W. Low frequency of p16/CDKN2A methylation in sporadic melanoma: comparative approaches for methylation analysis of primary tumors. Cancer Res, 57: 5336-5347, 1997.

  22. Gonzalgo M.L. and Jones, P.A. Rapid quantitation of methylation at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE). Nucleic Acids Res, 25: 2529-2531, 1997.

  23. Gonzalgo M.L., Liang, G., Spruck, C.H., Zingg, J.M., Rideout, W.M., and Jones, P.A. Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR. Cancer Res, 57: 594-599, 1997.

  24. Simoneau, A.R., Spruck, C.H., Gonzalez-Zulueta, M., Gonzalgo M.L., Chan, M.F., Tsai, Y.C., Dean, M., Steven, K., Horn, T. and Jones, P.A. Evidence for two tumor suppressor loci associated with proximal chromosome 9p to q and distal chromosome 9q in bladder cancer and the initial screening for GAS1 and PTC mutations. Cancer Res, 56: 5039-5043, 1996.

  25. Yang, A.S., Gonzalgo M.L., Zingg, J.M., Millar, R.P., Buckley, J.D., and Jones, P.A. The rate of CpG mutation in Alu repetitive elements within the p53 tumor suppressor gene in the primate germline. J Mol Biol, 258: 240-250, 1996.

  26. Gonzalez-Zulueta, M., Shibata, A., Ohneseit, P.F., Spruck, C.H., Busch, C., Shamaa, M., El-Baz, M, Gonzalgo M.L., Nichols, P.W., and Jones, P.A. High frequency of chromosome 9p allelic loss and CDKN2 tumor suppressor gene alterations in squamous cell carcinoma of the bladder. J Natl Cancer Inst, 87: 1383-1393, 1995.

  27. Pallavicini, M.G., Flake, A.W., Madden, D., Bethel, C., Duncan, B., Gonzalgo M.L., Haendel, S., Montoya, T., Roberts, L. Hemopoietic chimerism in rodents transplanted in utero with fetal human hemopoietic cells. Transplant Proc, 24: 542-543, 1992.

  28. Pallavicini, M.G., Langlois, R.G., Reitsma, M., Gonzalgo, M., Sudar, D., Montoya, T., Weier, H.U., Haendel, S. Comparison of strategies to detect and quantitate uniquely marked cells in intra- and inter-species hemopoietic chimeras. Cytometry 13: 356-367, 1992.

INVITED REVIEWS, EDITORIALS, BOOK CHAPTERS:
  1. Gonzalgo M.L. and Eastham, J.A. Wide excision radical prostatectomy: indications and technique. Contemp Urol, in press.

  2. Gonzalgo M.L., Datar, R.,H., Schoenberg, M.P., and Cote, R.J. The role of DNA methylation in development, diagnosis, and prognosis of bladder cancer. Urologic Oncology, in press.

  3. Schoenberg, M.P. and Gonzalgo M.L. Management of invasive and metastatic bladder cancer. In: Cambell-Walsh Urology, Ninth Edition. Wein, A.J., Kavoussi, L.R., Novick, A.C., Partin, A.W., and Peters, C.A., eds., Saunders, New York, in press.

  4. Gonzalgo M.L. Superficial bladder cancer. In: The Brady urological handbook. Parsons, J.K. and Wright, E.J., eds., T & F - Informa, London, in press..

  5. Gonzalgo M.L. Invasive bladder cancer and urinary diversion. In: The Brady urological handbook. Parsons, J.K. and Wright, E.K., eds., T & F - Informa, London, in press.

  6. George, B., Gonzalgo M.L., Datar, R.H., and Cote, R.J. Cell cycle alterations. In: Textbook of bladder cancer. Lerner, S.P., Schoenberg, M.P., and Sternberg, C., eds., T & F - Informa, London, 2006.

  7. Gonzalgo M.L., Su, L.M., and Partin, A.W. Minimally invasive techniques to diagnose and stage carcinoma of the prostate. In: Minimally invasive uro-oncologic surgery. Moore, R.G. and Bishoff, J.T., eds. Taylor & Francis, London, 2005.

  8. Gonzalgo M.L., Su, L.M., and Partin, A.W. Carcinoma of the prostate: diagnosis and staging. In: Minimally invasive urologic surgery. Moore, R.G., Bishoff, J.T., Loening, S., and Docimo, S.G., eds. Martin Taylor & Francis, London, 2005.

  9. Nakayama, M., Gonzalgo M.L., Yegnasubramanian, S., Lin, X., De Marzo, A.M., and Nelson, W.G. GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer. J Cell Biochem., 91: 540-552, 2004.

  10. Gonzalgo M.L., and Isaacs, W.B. Molecular pathways to prostate cancer. J Urol, 170: 2444-2452, 2003.

  11. Gonzalgo M.L. and Schoenberg, M.P. Tailoring surveillance of superficial bladder cancer. Contemp Urol, 15: 16-39, 2003.

  12. Liang, G., Gonzalgo M.L., Salem, C., and Jones, P.A. Identification of DNA methylation differences during tumorigenesis by methylation-sensitive arbitrarily primed polymerase chain reaction. Methods, 27: 150-155, 2002.

  13. Gonzalgo M.L. and Jones, P.A. High-throughput quantitation of DNA methylation using methylation-sensitive single-nucleotide primer extension (Ms-SNuPE). Methods, 27: 128-133, 2002.

  14. Gonzalgo M.L., Rodriguez, R., and Schoenberg, M.P. Biological pathways to bladder carcinogenesis. Semin Urol Oncol, 18: 256-263, 2000.

  15. Jones, P.A., Gonzalgo M.L., Tsutsumi, M., and Bender, C.M. DNA methylation in bladder cancer. Eur Urol, 33: 7-8, 1998.

  16. Gonzalgo M.L. and Jones, P.A. Mutagenic and epigenetic effects of DNA methylation. Mutat Res, 386: 107-118, 1997.

  17. Jones, P.A. and Gonzalgo M.L. Altered DNA methylation and genome instability: a new pathway to cancer? Proc Natl Acad Sci USA, 94: 2103-2105, 1997.
 
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