George  Netto, M.D.
George Netto, M.D.

Director of Surgical Pathology Molecular Diagnostics
Professor of Pathology, Urology and Oncology

Johns Hopkins University School of Medicine

Address:
Division of Surgical Pathology
Weinberg Building Room 2242
Baltimore, MD 21231 2410

Office: (410) 955-5082

Email: gnetto1@jhmi.edu


Publications


  

BOOK:

  1. Prostate Biopsy Interpretation JI Epstein & GJ Netto
    Fourth Edition; Lippincott Williams& Wilkins, Philadelphia, 2007 

PUBLICATIONS:

  1. Immunohistology and Molecular Diagnostics of The Prostate Neoplasms GJ Netto and JI Epstein. Chapter 16 Section I; in Diagnostic Immunohistochemistry. Churchill Livingston Elsevier, Third Edition, Ed. David Dabbs Ed. IN PRESS

  2. Immunohistology and Molecular Diagnostics of The Urinary Bladder Neoplasms GJ Netto and JI Epstein. Chapter 16 Section II; in Diagnostic Immunohistochemistry. Churchill Livingston Elsevier, Third Edition, Ed. David Dabbs Ed. IN PRESS

  3. Immunohistology and Molecular Diagnostics of The Renal Neoplasms GJ Netto and JI Epstein. Chapter 16  Section III; in Diagnostic Immunohistochemistry. Churchill Livingston Elsevier, Third Edition, Ed. David Dabbs Ed. IN PRESS

  4. Immunohistology and Molecular Diagnostics of The Testicular Neoplasms. GJ Netto and JI Epstein. Chapter 16 Section IV; in Diagnostic Immunohistochemistry. Churchill Livingston Elsevier, Third Edition, Ed. David Dabbs Ed. IN PRESS

  5. BENIGN MIMICKERS OF PROSTATE ADENOCARCINOMA ON NEEDLE BIOPSY & TRANSURETHRAL RESECTION: George J. Netto and Jonathan I Epstein Surgical Pathology Clinics, 2008 Volume 1, Issue 1, ISSN: 1875-9181 SAUNDERS

  6. Mesenchymal Tumors of the Prostate Donna E. Hansel MD PhD, George J Netto MD, Elizabeth A. Montgomery MD and Jonathan I. Epstein MD.Surgical Pathology Clinics, 2008 Volume 1, Issue 1, ISSN: 1875-9181 SAUNDERS

  7. Pathology of Liver Transplantation: Complications of Liver Transplantation. GJ Netto. chapter 34; Atlas of Liver Transplantation: Molmenti & Klintmalm; Ed; Elsevier Science 2002.

  8. Pathology of Liver Transplantation: Primary Hepatic Disease. GJ Netto.chapter 35; Atlas of Liver Transplantation: Molmenti & Klintmalm; Ed; Elsevier Science 2002.        
  9. Pathology of Liver Transplantation: Recurrence of Primary Hepatic Diseases in Transplanted Livers. GJ Netto. chapter 36Atlas of Liver Transplantation: Molmenti & Klintmalm; Ed; Elsevier Science 2002.

  10. Pathology of Liver Transplantation; Grading and staging Systems. GJ Netto . chapter 37; Atlas of Liver Transplantation: Molmenti & Klintmalm; Ed; Elsevier Science 2002.

Selected Peer Reviewed Articles

  1. Sarkis A, Bajorin D, Reuter V, Herr H, Netto G, Zhang Z-F , Schultz P, Cordon-Cardo C and Scher H:  Prognostic Value of p53 Nuclear Overexpression in Patients with Invasive Bladder Cancer Treated with Neoadjuvant MVAC. Journal of Clinical Oncology 1995; 13: 1384-1890.
  2. Scher H, Sarkis A, Reuter V, Cohen D, Netto G, Petrylak D, Lianes P, Fuks Z, Mendelsohn J and Cordon-Cardo C: Changing Pattern of Expression of the Epidermal Growth Factor Receptor and Transforming Growth Factor Alpha in the Progression of Prostatic Neoplasms. Clin. Cancer Res. 1995; 1(5): 545-550
  3. Nord JD, Stolfi RL, Alfieri AA, Netto G, Reuter V, Sternberg SS, Colofiore JR, Koultcher JA and Martin DS:  Apoptosis Induced in Advanced CD8F1- Murine Mammary Tumors by the Combination of PALA, MMPR and 6AN Precedes Tumor Regression and is Preceded by ATP Depletion.  Cancer Chemother Pharmacol.  1997; 40 (5): 376-384.
  4. Hogenauer C, Meyer RL, Netto GJ, Bell D, Little KH, Ferries L, Santa Ana CA, Porter JL, Fordtran JS :  Malabsorption due to cholecystokinin deficiency in a patient with autoimmune polyglandular syndrome type I. N. Engl. J. Med. 2001 ; 344:270-274.
  5. Nemunaitis J, Cunningham C, Tong AW, Post L, Netto G, Paulson AS, Rich D, Blackburn A, Sands B, Gibson B, Randlev B, Freeman S.: Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients. Cancer Gene Ther 2003; (10):341-52.
  6. Islas-Ohlmayer M, Padgett-Thomas A, Saad R, Melkus M, Cravens P. Martin M, Netto G and Garcia JV. Experimental Infection of NOD/SCID Mice Reconstituted with Human CD34+ Cells with Epstein-Barr Virus. J Virol 2004 (78): 13891-13900
  7. Tong A, Nemunaitis J, Su D, Zhang Y, Cunningham C, Senzer N, Netto G, Rich D, Mhashilkar A, Parker K, Coffee K, Ramesh R, Ekmekcioglu S, Grimm EA, van Wart Hood J, Merritt J and Chada S. Intratumoral Injection of INGN 241, a Nonreplicating Adenovector Expressing the Melanoma-Differentiation Associated Gene-7 (mda-7/IL24): Biologic Outcome in Advanced Cancer Patients. 
    Molecular Therapy 2005; (1):160-72.
  8. Sanchez S, Holmes H, Katabi N, Newman J, Domiatti-Saad R, Stone M andNetto GJ.  Composite Lymphocyte Rich Hodgkin Lymphoma and Peripheral T Cell Lymphoma Associated wih Epstein-Barr Virus. Case Report and Literature Review.Arch Pathol Lab Med 2006:130:107-112.
  9. G J Netto, DL Watkins, J W Williams, T Colby, G dePetris, F Sharkey, C Corless, D Lewin , L Petrovic, S Sharma, G Kanel , N Theise, A B West, A Koehler, N Jhala, J Lefkowitch, J Lezzoni, Linda Jennings, GW Tillery, G Klintmalm and The Hepatitis C 3 Trial Group. : Interobserver Agreement in Hepatitis C Grading and Staging and Banff Grading Schema for Acute Cellular Rejection: The “Hepatitis C 3” Multi-institutional Trial Experience. Arch Pathol Lab Med 2006:130:1157-1162
  10. Netto GJ, Altrabulsi  B, Katabi N, Martin P, Burt K, Levy M, Sanchez E, Watkins DL, Jennings L, Klintmalm G and Goldstein R: Radio Frequency Ablation of Hepatocellular Carcinoma Prior to Liver Transplantation: A Histologic and TUNEL Study. Liver International 2006: 26(6): 746-751
  11. Ueno T, Barri YM, Netto GJ, Martin A, Onaca N, Sanchez EQ, Chinnakotla S, Randall HB, Dawson S, Levy MF, Goldstein RM, Klintmalm GB. Liver and kidney transplantation for polycystic liver and kidney-renal function and outcome. Transplantation. 2006: 82:501-5077.
  12. Netto GJ, Epstein JI: Widespread High Grade Prostatic Intraepithelial Neoplasia on Prostatic Needle Biopsy: A Significant Likelihood of Subsequently Diagnosed Adenocarcinoma. Am J Surg Pathol 2006: 30(9):1184-1188
  13. E Kuhn, J De Anda, S Manoni, G Netto and J Rosai: Renal Cell Carcinoma Associated with Prominent Angioleiomyoma-Like Proliferation: Report of Five cases and review of The Literature. Am J Surg Pathol 2006: 30(11): 1372-1361
  14. Hansel DE, DeMarzo AM, Platz EA, Jadallah S , Hicks J, Epstein1JI, Partin AW, and Netto GJ:Early Prostate Cancer Antigen (EPCA) Expression in Predicting Presence of Prostate Cancer among Men with Histologically Negative Biopsies. J Urol  2007: 177(5)1736-1740
  15. Owens C, Epstein JI and Netto GJ: Distinguishing Prostatic From Colorectal Adenocarcinoma on Biopsy Samples: The Role of Morphology and Immunohistochemistry. Arch Pathol Lab Med 2007:131(4);599-603
  16. Gilliland GD, Gilliland G, Fincher T, Harrington J, Gilliland JM, Netto G and Burt K. Timing of return to normal activities after orbital floor fracture repair. Plast Reconstr Surg. 2007;120:245-251.
  17. Paulson KE, Rieger-Christ K, McDevitt MA, Kuperwasser C, Kim J, Unanue VE, Zhang X, Hu M, Ruthazer R, Berasi SP, Huang CY, Giri D, Kaufman S, Dugan JM, Blum J, Netto G, Wazer DE, Summerhayes IC, and Yee AS. Alterations of the HBP1 Transcriptional Repressor Are Associated with Invasive Breast Cancer. Cancer Res. 2007;67:6136-45.
  18. Klintmalm GB, Washburn WK, Rudich SM, Heffron TG, Teperman LW, Fasola C, Eckhoff DE, Netto GJ, Katz E. Corticosteroid-free immunosuppression with daclizumab in HCV(+) liver transplant recipients: 1-year interim results of the HCV-3 study. Liver Transpl. 2007;13(11):1521-31.
  19. Grosso GF, Kelleher CC, Timothy J. HarrisTJ, Maris CH, Hipkiss EL, DeMarzo A, Anders R,  Netto G, Getnet D, Bruno TB, Goldberg MV, Pardoll DM and Drake CG. Expression of LAG-3 on CD8 T cells regulates their accumulation and effector function in murine self and tumor tolerance systems. J Clin Investigation 2007: 117(11):3383-92
  20. Osunkoya AO, Netto GJ, Epstein JI: Colorectal adenocarcinoma involving the prostate: report of 9 cases. Hum Pathol 2007; 38(12):1836-41
  21. Lane Z, Epstein JI, Ayub S and Netto GJ : Prostatic Adenocarcinoma In Colorectal Biopsy: Clinical And Pathologic Features. Hum Pathol 2008;39(4):543-9.
  22. Osunkoya AO, Hansel DE, Sun X, Netto GJ, Epstein JI. Aberrant diffuse expression of p63 in adenocarcinoma of the prostate on needle biopsy and radical prostatectomy: report of 21 cases. Am J Surg Pathol. 2008 Mar;32(3):461-7.
  23. Sireci AN, Rodriguez  R, Swierczynski  SL, Netto GJ and Argani, P:  Fat-Predominant Mixed Epithelial Stromal Tumor (MEST):  Report of a Unique Case Mimicking Angiomyolipoma.  Int J Surg Pathol  2008;16(1):73-7.
  24. Nagpal JK, Dasgupta S, Jadallah S, Chae YK, Ratovitski EA, Toubaji A, Netto GJ, Eagle T, Nissan A, Sidransky D, Trink B. Profiling the expression pattern of GPI transamidase complex subunits in human cancer. Mod Pathol. 2008 (8):979-91.
  25. Argani P, Netto GJ, Parwani AV.Papillary renal cell carcinoma with low-grade spindle cell foci: a mimic of mucinous tubular and spindle cell carcinoma.Am J Surg Pathol. 2008(9):1353-9
  26. Goodwin AC, Jadallah S, Toubaji A, Lecksell K, Hicks J,Kowalski J, Bova GS, 3, De Marzo AM, Netto GJ, and Casero RA Jr: Increased Spermine Oxidase Expression in Human Prostate Cancer and Prostatic Intraepithelial Neoplasia Tissues. Prostate 2008 (7):766-72
  27. Netto GJ, Nakai Y, Nakayama M, Jadallah S, Toubaji A, Nonomura N, Albadine R , Hicks J, Epstein JI, Yegnasubramanian S, Nelson WG, and De Marzo AM: Global DNA Hypomethylation in Intratubular Germ Cell Neoplasia and Seminoma, but Not in Non-Seminomatous Male Germ Cell Tumors.Modern Pathol 2008; 21(11):1337-44.
  28. Wang W, Tavora F, Sharma R, Eisenberger M and Netto GJ. PSMA Expression in Schwannoma: A Potential Clinical Mimicker of Metastatic Prostate Carcinoma. Urol Oncology (In Press)
  29. Cheung WL, Albadine R, Chan T, R. Sharma R and Netto GJ: Phosphorylated H2AX in Non-Invasive Low Grade Urothelial Carcinoma of Urinary Bladder: Correlation with Tumor Recurrence. J Urol  (In Press)
  30. R Albadine, W Wang, NA Brownlee, A Toubaji, A Billis, JI Epstein, P Argani, AJ Garvin, Couzi, R, E Schaeffer,CP Pavlovich, GJ Netto: Topoisomerase IIA Status in Renal Medullary Carcinoma: Immunoexpression and Gene Copy Alterations of a Potential Target of Therapy.  J Urol (In Press)
  31. Klock C, Gomes R, João M, Netto G. Prostate Melanosis Associated With Acinar Adenocarcinoma. Int J Surg Pathol. (In Press)
  32. Tamara L. Lotan, Antoun Toubaji, Roula Albadine, Mathieu Latour, Mehsati Herawi, Alan K. Meeker, Angelo M. DeMarzo, Elizabeth A. Platz, Jonathan I. Epstein, and George J. NettoTMPRSS2-ERG Gene Fusions are Infrequent in Prostatic Ductal Adenocarcinomas. Modern Pathol (In Press)
  33. K Fujita, CP Pavlovich, G Netto, Y Konishi, WB Isaacs, S Ali, A De Marzo and A Meeker: Specific detection of prostate cancer cells in urine by multiplex immunofluorescence cytology. Hum Pathol (In Press)
  34. Margulis V, Lotan Y, Karakiewicz PI, Fradet Y, Ashfaq R, Capitanio U, MontorsiF, Bastian PJ, Nielsen ME, Müller SC, Rigaud J, Heukamp LC, Netto G,Lerner SP, Sagalowsky AI, Shariat SF. Multi-institutional validation of the predictive value of Ki-67 labeling index in patients with urinary bladder cancer.J Natl Cancer Inst. 2009 Jan 21;101(2):114-9.

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