Edward M. Schaeffer, M.D., Ph.D.
Edward M. Schaeffer, M.D., Ph.D.

R. Christian B. Evensen Professor
Associate Professor of Urology, Oncology, Pathology
Director of the Prostate Cancer Program
Director of International Urology
Co-Director Prostate Cancer Multi-Disciplinary Clinic

Johns Hopkins Medical Institutions
600 North Wolfe St, Marburg 145 Baltimore MD 21287

Appointments: 410-955-6100

Office: 410-502-2733

Email: eschaeffer@jhmi.edu

Fax: 410-955-0833
Discharge Instructions for patients

Free Access to abstracts at PubMed


  1. Oefielein M, Grapey D, Schaeffer EM, Chin-Chance C, and BushmanW.  (1996)  Pax-2: Developmental Gene Constitutively Expressed in Mouse Epididymis and ductus Deferens, J Urol. 156:1204-1207,
  2. Debnath, J., Chamorro, M., Czar, M.J., Schaeffer, E.M., Lenardo, M.J., Varmus, H.E. and Schwartzberg, P.L. (1999) Rlk/Txk encodes two forms of a novel cysteine-string tyrosine kinase activated by Src family kinases. Mol. Cell Biol. 19: 1498-1507.
  3. Schaeffer EM, Pohlman A and Hall JB. (1999)  Oxygenation Improves in Intubated Mechanically Ventilated Patients with Status Asthmaticus During Heliox Therapy.  Crit Care Med, 27: 2666-2670.
  4. Schaeffer, EM., Debnath, J., Yap, G. McVicar, D., Sher, A. Littman, D., Varmus, H. E., Lenardo, M.J. and Schwartzberg, P., (1999) Essential roles for the Tec kinases Rlk and Itk in T cell receptor signaling and adaptive immunity.  Science, 284 638-641.
  5. Sun, Z., Arendt, C., Ellmeirer, W., Schaeffer, EM, Sunshine, M., Annes, J., Petrzilka, Kupfer, A., Schwartzberg, P. and Littman, D. (2000) Requirement for PKC-thetain T cell antigen receptor-mediated T cell activation and induction of the NF-KB signaling pathway.  Nature, 404:402-7.
  6. Schaeffer, EM., Debnath J, Broussard C, McVicar and Schwartzberg, P. (2000) Tec family kinases Alter Thresholds for Thymocyte Development and Selection. Journal of Experimental Medicine.  J Exp Med Oct 2;192(7):987-1000.
  7. Czar, MJ, Debnath J, Schaeffer EM, Lewis CM, Schwartzberg PL. (2001)  Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk.  Biochem Soc Trans. Nov;29(Pt 6):863-7.
  8. Schaeffer, EM Yap GS, Lewis CM, Czar DW, McVicar DW, Cheever AW, Sher A and Schwartzberg PL. (2001) Mutation of Tec family kinases alters T helper cell differentiation.  Nature  Immunol. 2(12):1138-8. 
  9. Schaeffer, EM and Bhayani SB. (2003) Inguinal Bladder Hernia, Urology 62(5) 940.
  10. Schaeffer, EM, Epstein JI and Walsh PC.  (2004) Amyloidosis of the Seminal Vesicle and Hematospermia. Journal of Urology.171(6):2382
  11. Schaeffer EM and Walsh PC. (2004) Hypogonadism and Prostate Cancer, Considerations for Testosterone Replacement Therapy. New England Journal of Medicine 350(19):2004-6;
  12. Allaf ME, Bhayani SB, Link RE, Schaeffer EM, Varkarakis JM, Shadpour P, Lima G Kavoussi LR. (2005) Laparoscopic retroperitoneal lymph node dissection: duplication of open technique. Urology. Mar;65(3):575-7.
  13. Schaeffer EM and Kavoussi LR, (2005) Adrenal Myelolipoma.  Journal of  Urology 173(5):1760.
  14. Schaeffer EM, Jarow JP Jr, Vrablic J, Jarow JP. (2006) Duplex ultrasonography detects clinically significant anomalies of penile arterial vasculature affecting surgical approach to penile straightening. Urology. (1):166-9.
  15. Warlick CW, Allaf ME, Guilherme LC, Varkaraksi JM Schaeffer EM, Kavoussi LR, Jarrett TW, and Solomon SB.  Clinical Sequlae of Radiographic Iceball Involvement of the Collecting System During Percutaneous Renal Tumor Cryoablation.  Urology 2006; 67(5):918-22.
  16. Muntener M, Nielsen ME, Romero FR, Schaeffer EM, Allaf ME, Brito FA, Pavlovich CP, Kavoussi LR, Jarrett TW.  Long-Term Oncologic Outcome after Laparoscopic Radical Nephroureterectomy for Upper Tract Transitional Cell Carcinoma.  Eur Urol. 2007 Jan 16
  17. Muntener M, Schaeffer EM, Nielsen ME, Romero FR, Allaf ME, Brito FA, Pavlovich CP, Kavoussi LR, Jarrett TW.   Rebuttal from Authors re: Peter Albers. Quality Criteria of Laparoscopic Nephroureterectomy. Eur Urol. 2007;51:1481-2
  18. Hernandez DJ, Schaeffer EM, Allaf ME.  Pyeloduodenal fistula due to advanced upper tract malignancy.  Urology. 2007 Jun;69(6):1206-7.
  19. Bivalacqua TJ, Alphs H, Aksentijevich I, Schaeffer EM, Schoenberg MP. Paraneoplastic polyarthritis from non-small-cell lung cancer metastatic to the bladder. J Clin Oncol. 2007 Jun 20;25(18):2621-3.
  20. Romero FR, Schaeffer EM, Muntener M, Trock B, Kavoussi LR, Jarrett TW.  Oncologic outcomes of extravesical stapling of distal ureter in laparoscopic nephroureterectomy.  J Endourol. 2007 Sep;21(9):1025-7.
  21. Berger J Lang, E and Schaeffer EM.  Urologic Radiographic Manifestations of Ehlers-Danlos Syndrome.  J Urol  2007 October, 178(4pt1): 1490.
  22. Zahurak M, Parmigiani G, Yu W, Scharpf RB, Berman D, Schaeffer E, Shabbeer S, Cope L. Pre-processing Agilent microarray data. BMC Bioinformatics. 2007 May 1;8:142.
  23. Muntener M, Schaeffer EM, Romero FR, Nielsen ME, Allaf ME, Brito FA, Pavlovich CP, Kavoussi LR, Jarrett TW.  Incidence of local recurrence and port site metastasis after laparoscopic radical nephroureterectomy. Urology November 72(5):864-8.
  24. Nielsen ME, Lima G, Schaeffer EM, Porter J, Cadeddu JA, Tuerk I, Kavoussi LR.  Oncologic efficacy of laparoscopic RPLND in treatment of clinical stage I nonseminomatous germ cell testicular cancer.  Urology. 2007 Dec;70(6):1168-72.
  25.  Bivalacqua TJ, Schaeffer EM, Alphs H, Mettee L, Wagner AA, Su LM, Pavlovich CP. Intraperitoneal Effects of Extraperitoneal Laparoscopic Radical Prostatectomy. Urology. 2008 Mar 18.
  26. Bivalacqua TJ, Guzzo TJ, Schaeffer EM, Gebska MA, Champion HC, Burnett AL, Gonzalgo ML. Application of Evicel to Cavernous Nerves of the Rat Does Not Influence Erectile Function In Vivo. Urology. 2008 Jun 16.
  27. Schaeffer EM, TJ. Bivalacqua, S Hortopan, C Weiss, S Mitchell and M. Allaf.  Cystoscopic Management of an Extruded Coil from Arteriovenous Fistula Embolization Using Arthroscopic Instruments.J Endourol 2008July 22 1567-9.
  28. Guzzo TJ, Schaeffer EM, Allaf ME. Laparoscopic Radical Nephroureterectomy with En-Bloc Distal Ureteral and Bladder Cuff Excision Using a Single Position Pneumovesicum Method. Urology. 2008 Jul 29.
  29. Edward M. Schaeffer, Luigi Marchionni, Zhenhua Huang, Brian Simons, Amanda Blackman, Wei Yu, Giovanni Parmigiani and David M. Berman.  Androgen induced programs for prostate epithelial growth and invasion arise in embryogenesis and are reactivated in cancer.  Oncogene 2008 Sept 15 Epub
  30. Hernandez DJ, Roberts WB, Miles-Thomas J, Magheli A, Saha S, Schaeffer EM, Racusen LC, Allaf ME.  Can Ischemic Preconditioning Ameliorate Renal Ischemia-Reperfusion Injury in a Single-Kidney Porcine Model? J Endourol. 2008 Oct 18. [Epub ahead of print]
  31. Nielsen ME, Schaeffer EM, Marschke P, Walsh PC.  High Anterior Release of the Levator Fascia Improves Sexual Function Following Open Radical Retropubic Prostatectomy. J Urol. 2008 Oct 17. [Epub ahead of print]
  32. Semins MJ, Allaf ME, Lang E Schaeffer EM.   Delineation of Inferior Vena Caval Anatomy With 3-Dimensional Computerized Tomography Reconstruction  J Urol. 2008 Oct 31. [Epub ahead of print]
  33. Guzzo TJ, Pierorazio PM, Schaeffer EM, Fishman EK, Allaf ME. The Accuracy of Multidetector Computerized Tomography for Evaluating Tumor Thrombus in Patients With Renal Cell Carcinoma.  J Urol. 2008 Dec 17.
  34. Guzzo T, Allaf ME, Pavlovich CP, Schaeffer EM.  Perioperative Outcomes of Elderly Patients Undergoing Laparoscopic Renal Procedures. Urology Dec 30 2008 [Epub]
  35. Guzzo TJ, Schaeffer EM, McNeil BK, Pollock RA, Pavlovich CP, Allaf ME.  Laparoscopic Radical Nephrectomy for Patients with Pathologic T(3b) Renal-Cell Carcinoma: The Johns Hopkins Experience.  J Endourol. 2009 Jan 2. [Epub ahead of print]
  36. Schaeffer EM , H Ballentine Carter, Anna Kettermann, Stacy Loeb, Luigi Ferrucci, Patricia Landis, Bruce J Trock, E Jeffrey Metter.  Prostate Specific Antigen Testing among the Elderly: When to Stop?  J Urol 2009 April 1606-1-1437)
  37. Guzzo TJ, Bivalacqua TJ, Pierorazio PM, Varkarakis J, Schaeffer EM, Allaf ME. Xanthogranulomatous pyelonephritis: presentation and management in the era of laparoscopy..BJU Int. 2009 Apr 15. [Epub ahead of print]
  38. Loeb S, Schaeffer EM, Chan DW, Carter HB, Walsh PC, Sokoll LJ.  Investigation of human anti-mouse antibodies as potential cause of postprostatectomy PSA elevation.  Urology. 2009 May;73(5):947-9.
  39. Albadine R, Wang W, Brownlee NA, Toubaji A, Billis A, Argani P, Epstein JI, Garvin AJ, Cousi R, Schaeffer EM, Pavlovich C, Netto GJ.  Topoisomerase II alpha status in renal medullary carcinoma: immuno-expression and gene copy alterations of a potential target of therapy.  J Urol. 2009 Aug;182(2):735-40. Epub 2009 Jun 18.
  40. Loeb S, Schaeffer EM.  Risk factors, prevention and early detection of prostate cancer. Prim Care. 2009 Sep;36(3):603-21.
  41. Loeb S, Carter HB, Schaeffer EM, Ferrucci L, Kettermann A, Metter EJ., Should prostate specific antigen be adjusted for body mass index? Data from the Baltimore Longitudinal Study of Aging. J Urol. 2009 Dec;182(6):2646-51.
  42.   Loeb S, Schaeffer EM, Trock BJ, Epstein JI, Humphreys EB, Walsh PC. What Are the Outcomes of Radical Prostatectomy for High-risk Prostate Cancer?  Urology. 2009 Nov 19.
  43. Schaeffer EM, Guzzo TJ, Furge KA, Netto G, Westphal M, Dykema K, Yang X, Zhou M, Teh BT, Pavlovich CP.  Renal medullary carcinoma: molecular, pathological and clinical evidence for treatment with topoisomerase-inhibiting therapy. BJU Int. . [Epub ahead of print]
  44. Brandt WD, Matsui W, Rosenberg JE, He X, Ling S, Schaeffer EM, Berman DM. Urothelial carcinoma: Stem cells on the edge.  Cancer Metastasis Rev. 2009 Dec;28(3-4):291-304.
  45. Loeb S, Carter HB, Schaeffer EM, Ling SM, Kettermann A, Ferrucci L, Metter EJ  Bone mineral content and prostate cancer risk: data from the Baltimore Longitudinal Study of Aging. BJU Int. 2010 Jan 8.
  46. Stacy Loeb, Edward M. Schaeffer, Jonathan I. Epstein.  The Vanishing Prostate Cancer Phenomenon. Urology. 2010 Jan 14
  47. Pierorazio PM, Guzzo TJ, Han M, Bivalacqua TJ, Epstein JI, Schaeffer EM, Schoenberg M, Walsh PC, Partin AW.  Long-term Survival After Radical Prostatectomy for Men With High Gleason Sum in Pathologic Specimen.  Urology. 2010 Mar 27.
  48. Loeb S, Partin AW, Schaeffer EM.  Complications of pelvic lymphadenectomy: do the risks outweigh the benefits?  Rev Urol. 2010 Winter;12(1):20-4.
  49. Loeb S, Makarov DV, Schaeffer EM, Humphreys EB, Walsh PC. Prostate Specific Antigen at the Initial Diagnosis of Metastasis to Bone in Patients After Radical Prostatectomy. J Urol. 2010 Jul;184(1):157-161. Epub 2010 May 16."
  50. Ross AE, Emadi A, Marchionni L, Hurley PJ, Simons BW, Schaeffer EM, Vuica-Ross M., Dimeric naphthoquinones, a novel class of compounds with prostate cancer cytotoxicity. BJU Int. 2010 Dec 22. [Epub ahead of print]
  51. Loeb S, Carter HB, Schaeffer EM, Kettermann A, Ferrucci L, Metter EJ.  Distribution of PSA velocity by total PSA levels: data from the Baltimore Longitudinal Study of Aging.  Urology. 2011 Jan;77(1):143-7.
  52. Ross AE, Marchionni L, Phillips T, Miller RM, Hurley P, Simons BW, Salmasi A, Schaeffer AJ, Gearhart JP, Schaeffer EM,  Molecular Effects of Genestein on Male Urethral Development. J Urol. Accepted
  53. Ross AE, Marchionni L, Vuica-Ross M, Cheadle C,  Fan J, Berman DM, Schaeffer EM. Gene Expression Pathways of High Grade Localized Prostate Cancer. The Prostate. Accepted.


  1. Schaeffer AJ and Schaeffer EM. Infections of the Urinary Tract Campbell-Walsh Urology Ninth Edition. Saunders Elsevier. Philadelphia PA
  2. Schaeffer EM.  Renal Parenchymal Tumors.  Brady Urology Manual.  Informa Healthcare 2006
  3. Schaeffer EM.  Antimicrobial Prophylaxis for Common Urologic Procedures.  Brady Urology Manual.  Informa Healthcare 2006
  4. Schaeffer EM and Schaeffer AJ  Antimicrobial Prophylaxis: Contemporary Indications.  AUA Update Series 2008
  5. Schaeffer EM, Nielsen ME, Gonzalgo ML and Schoenberg MP. Nerve Sparing Cystectomy. Bladder Cancer: Moving the Field Forward.  The Humana Press. 2009 In Press
  6. Schaeffer AJ and Schaeffer EM Infections of the Urinary Tract Campbell-Walsh Urology Tenth Edition, Saunders Elsevier. Philadelphia PA. In press 2010
  7. Schaeffer EM, Partin AW, Lepor H and Walsh PC. Radical Retropubic Prostatectomy. Campbell-Walsh Urology Tenth Edition. Saunders Elsevier. Philadelphia PA. In press 2010

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