Edward M. Schaeffer, M.D., Ph.D. Assistant Professor of Urology Johns Hopkins Medical Institutions Email:eschaef4@jhmi.edu

   PUBLICATIONS

1. Oefielein M, Grapey D, Schaeffer EM, Chin-Chance C, and BushmanW.  (1996)  Pax-2: Developmental Gene Constitutively Expressed in Mouse Epididymis and ductus Deferens, J Urol. 156:1204-1207,
2. Debnath, J., Chamorro, M., Czar, M.J., Schaeffer, E.M., Lenardo, M.J., Varmus, H.E. and Schwartzberg, P.L. (1999) Rlk/Txk encodes two forms of a novel cysteine-string tyrosine kinase activated by Src family kinases. Mol. Cell Biol. 19: 1498-1507.
3. Schaeffer EM, Pohlman A and Hall JB. (1999)  Oxygenation Improves in Intubated Mechanically Ventilated Patients with Status Asthmaticus During Heliox Therapy.  Crit Care Med, 27: 2666-2670.
4. Schaeffer, EM., Debnath, J., Yap, G. McVicar, D., Sher, A. Littman, D., Varmus, H. E., Lenardo, M.J. and Schwartzberg, P., (1999) Essential roles for the Tec kinases Rlk and Itk in T cell receptor signaling and adaptive immunity.  Science, 284 638-641.
5. Sun, Z., Arendt, C., Ellmeirer, W., Schaeffer, EM, Sunshine, M., Annes, J., Petrzilka, Kupfer, A., Schwartzberg, P. and Littman, D. (2000) Requirement for PKC-thetain T cell antigen receptor-mediated T cell activation and induction of the NF-KB signaling pathway.  Nature, 404:402-7.
6. Schaeffer, EM and Schwartzberg, P. L. (2000), Tec Family Kinases in Lymphocyte Development and Function.  Curr. Opin.

7. Schaeffer, EM., Debnath J, Broussard C, McVicar and Schwartzberg, P. (2000) Tec family kinases Alter Thresholds for Thymocyte Development and Selection. Journal of Experimental Medicine.  J Exp Med Oct 2;192(7):987-1000.
8. Czar, MJ, Debnath J, Schaeffer EM, Lewis CM, Schwartzberg PL. (2001)  Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk.  Biochem Soc Trans. Nov;29(Pt 6):863-7.
9. Schaeffer, EM Yap GS, Lewis CM, Czar DW, McVicar DW, Cheever AW, Sher A and Schwartzberg PL. (2001) Mutation of Tec family kinases alters T helper cell differentiation.  Nature  Immunol. 2(12):1138-8. 
10. Schaeffer, EM and Bhayani SB. (2003) Inguinal Bladder Hernia, Urology 62(5) 940.
11. strong>Schaeffer, EM, Epstein JI and Walsh PC.  (2004) Amyloidosis of the Seminal Vesicle and Hematospermia. Journal of Urology.171(6):2382
12. Schaeffer EM and Walsh PC. (2004) Hypogonadism and Prostate Cancer, Considerations for Testosterone Replacement Therapy. New England Journal of Medicine 350(19):2004-6;
13. Allaf ME, Bhayani SB, Link RE, Schaeffer EM, Varkarakis JM, Shadpour P, Lima G Kavoussi LR. (2005) Laparoscopic retroperitoneal lymph node dissection: duplication of open technique.
    Urology. Mar;65(3):575-7.
14. Schaeffer EM and Kavoussi LR, (2005) Adrenal Myelolipoma.  Journal of  Urology 173(5):1760.
15. Schaeffer EM, Jarow JP Jr, Vrablic J, Jarow JP. (2006) Duplex ultrasonography detects clinically significant anomalies of penile arterial vasculature affecting surgical approach to penile straightening. Urology. (1):166-9.
16. Schaeffer EM.  (2006) Prophylactic use of antimicrobials in commonly performed outpatient urologic procedures.  Nature Clinic
17. Warlick CW, Allaf ME, Guilherme LC, Varkaraksi JM Schaeffer EM, Kavoussi LR, Jarrett TW, and Solomon SB.  Clinical Sequlae of Radiographic Iceball Involvement of the Collecting System During Percutaneous Renal Tumor Cryoablation.  2006; 67(5):918-22.
18. Nielsen ME, Schaeffer EM, Veltri RW, Schoenberg MP, Getzenberg RH.  Urinary markers in the detection of bladder cancer: what's new?  Curr Opin Urol. 2006;16(5):350-5
19. Muntener M, Nielsen ME, Romero FR, Schaeffer EM, Allaf ME, Brito FA, Pavlovich CP, Kavoussi LR, Jarrett TW.  Long-Term Oncologic Outcome after Laparoscopic Radical Nephroureterectomy for Upper Tract Transitional Cell Carcinoma.  Eur Urol. 2007 Jan 16
20. Muntener M, Schaeffer EM, Nielsen ME, Romero FR, Allaf ME, Brito FA, Pavlovich CP, Kavoussi LR, Jarrett TW.   Rebuttal from Authors re: Peter Albers. Quality Criteria of Laparoscopic Nephroureterectomy. Eur Urol. Jan 16 2007
21. Zahurak M, Parmigiani G, Yu W, Scharpf RB, Berman D, Schaeffer E, Shabbeer S, Cope L. Pre-processing Agilent microarray data.  BMC Bioinformatics. 2007 May 1;8:142
22. Hernandez DJ, Schaeffer EM, Allaf ME.  Pyeloduodenal fistula due to advanced upper tract malignancy.  Urology. 2007 Jun;69(6):1206-7.
23. Bivalacqua TJ, Alphs H, Aksentijevich I, Schaeffer EM, Schoenberg MP. Paraneoplastic polyarthritis from non-small-cell lung cancer metastatic to the bladder. J Clin Oncol. 2007 Jun 20;25(18):2621-3.
24. Berger J, Lang, E and Schaeffer EM.  Urological radiographic manifestations of the Ehlers-Danlos syndrome.  J Urol. 2007 Oct;178(4 Pt 1):1490.
25. Romero FR, Schaeffer EM, Muntener M, Trock B, Kavoussi LR, Jarrett TW.  Oncologic outcomes of extravesical stapling of distal ureter in laparoscopic nephroureterectomy.
    J Endourol. 2007 Sep;21(9):1025-8.

   TEXTBOOK CHAPTERS

1. Schaeffer AJ and Schaeffer EM. Infections of the Urinary Tract Campbell-Walsh Urology Ninth Edition. Saunders Elsevier. Philadelphia PA

2. Schaeffer EM.  Renal Parenchymal Tumors.  Brady Urology Manual.  Informa Healthcare 2006
   

3. Schaeffer EM.  Antimicrobial Prophylaxis for Common Urologic Procedures.  Brady Urology Manual.  Informa Healthcare 2006