The James Buchanan Brady Urological Institute
 
 
 
Donald S. Coffey, Ph.D. Donald S. Coffey, Ph.D.
The Catherine Iola and J. Smith Michael Distinguished Professor of Urology
University Distinguished Service Professor of Urology
Professor of Oncology
Professor of Pharmacology and Molecular Sciences
Professor of Pathology

Johns Hopkins Medical Institutions
Principal Professional Staff
Johns Hopkins University Applied Physics Laboratory

PUBLICATIONS

  1. Meeker, A.K.and Coffey, D.S. Telomerase: a Promising Marker of Biological Immortality of Germ, Stem and Cancer Cells. A Review. Biochemistry (Moscow) Vol. 62, No. 11, pp. 1323-1331, 1997.

  2. Schürmann, M.G. and Coffey, D.S. Aptamer Adaptability: Utilizing Tumor Cell Surface Heterogeneity to Self-Select Appropriate Diagnostic and Therapeutic Agents. IN: Advances in Molecular and Cell Biology {Bittar, E.E. and Getzenberg, R.H., Eds.}, Vol. 24, JAI Press, Inc., Greenwich, Connecticut and London, England, pp. 77-93, 1997.

  3. Partin, A.W., Briggman, J.V., Subong, E., Szaro, R., Oreper, A., Wiesbrock, S., Meyer, J., Coffey, D.S. and Epstein, J.I. Preliminary Immunohistochemical Characterization of A Monoclonal Antibody (PRO:4-216) Prepared from Human Prostate Cancer Nuclear Matrix Proteins. Urology 50, (5): pp. 800-808, 1997.

  4. Garcia-Schürmann, M., Partin, A.W. and Coffey, D.S . The Molecular and Cellular Biology of Urologic Cancers. Urologic Oncology {J. Oesterling and J. Richie, eds.}, W. B. Saunders Company, Philadelphia, pp. 3-15, 1997.

  5. Garcia-Schürmann, M. and Coffey, D.S. The Concept of Evolution in the Pathogenesis and Treatment of Prostate Cancer British Journal of Urology 79, (2):9-17, 1997

  6. Coffey, D.S Prostate Cancer Metastatis: Talking the Walk. Nature Medicine 2:1305, 1996

  7. Posadas, E.M., Criley, S.R. and Coffey, D.S. Chaotic Oscillations in Cultured Cultured Cells: Rat Prostate Cancer. Cancer Research 56, 3682-3688, 1996.

  8. Meeker, A.K., Sommerfeld, H.J. and Coffey, D.S. Telomerase is Activated in the Prostate and Seminal Vesicles of the Castrated Rat. Endrocrinology 137, (12): 5743-5746,

  9. Epner, D. E and Coffey, D.S There are Multiple Forms of Glyceraldehyde-3-Dehydrogenase in Prostate Cancer Cells and Normal Prostate Tissue. Prostate 27: 372-378, 1996.

  10. Griffiths, K., Coffey, D., Cockett, A., diSant'Agnese, A., Ichikawa, T., Krieg, M., Lee, C., McKeehan, W., Schalken, J., Sciarra, F., Steiner, G., Sugimura, Y., and Yamanaka, H. The Regulation of Prostatic Growth. IN: Proceedings of the 3rd International Consultation on Benign Prostatic Hyperplasia (BPH). Cockett, A.T.K., Khoury, S., Aso, Y., Chatelain, C., Denis, L., Griffiths, K. and Murphy, G. (Eds.), Monaco, June 26-28, 1995, pp. 73-115

  11. Sommerfeld, H. J., Meeker, A. K., Piatyszek, M. A., Bova, G. S., Shay, J. W. and Coffey, D.S Telomerase Activity: A Prevalent Marker of Malignant Human Prostate Tissue. Cancer Res. 56:218, 1996.

  12. Coffey, D. What is the Prostate and What is its Function? Handbook of Andrology, pp. 21-24, April 1995.

  13. Sommerfeld, H. J., Meeker, A. K., Posadas, E. M. and Coffey, D.S Frontiers in Prostate Cancer: Telomeres and Chaos. Cancer 75: 2027-2035, 1995.

  14. M.C. Luke and Coffey, D.S. The Male Sex Assessory Tissues. Structure, Androgen Action and Physiology. IN: The Physiology of Reproduction, Second Edition. Knobil, E. and Neill, J.D. (Eds.), Raven Press, Ltd., New York, 1994, pp. 1435-1487.

  15. Veltri, R. W., Partin, A. W., Epstein, J. I., Marley, G. M., Miller, C. M., Singer, D. S., Patton, K. P., Criley, S. R. and Coffey, D.S Quantitative Nuclear Morphometry, Markovian Texture Descriptors, and DNA Content Captured on a CAS-200 Image Analysis System, Combined with PCNA anD Her2/Neu Immunohistochemistry for Prediction of Prostate Cancer Progression. J. Cell. Biochem. 19:249-258, 1994.

  16. Rinker-Schaeffer, C.W., Partin, A.W., Isaacs, W.B., Coffey, D.S. and Isaacs, J.T. Molecular and Cellular Changes Associated With the Acquisition of Metastatic Ability by Prostatic Cancer Cells. Prostate 25:249-265, 1994.

  17. Juniewicz, P.E., Berry, S.J., Coffey, D.S., Strandberg, J.D. and Ewing, L.L. The Requirement of the Testis in Establishing the Sensitivity of the Canine Prostate to Develop Benign Prostatic Hyperplasia. J. Urol. 152:996-1001, 1994.

  18. Partin, A.W. and Coffey, D.S. Benign and Malignant Prostatic Neoplasms: Human Studies. Recent Prog. Horm. Res. 49:293-331, 1994.

  19. Luke, M.C. and Coffey, D.S. Human Androgen Receptor Binding to the Androgen Response Element of Prostate Specific Antigen. J. Androl. 15:41-51, 1994.

  20. Coffey, D.S Prostate Cancer. An Overview of an Increasing Dilemma. Cancer 71:880-886, 1993.

  21. Pienta, K.J., Murphy, B.C., Getzenberg, R.H. and Coffey, D.S. The Tissue Matrix and the Regulation of Gene Expression in Cancer Cells. IN: Advances in Molecular and Cell Biology, Vol. 5, pp. 131-156, JAI Press, Inc., 1993.

  22. Walensky, L.D., Coffey, D.S., Chen, T.-H., Wu, T.-C. and Pasternack, G.R. A Novel Mr 32,000 Nuclear Phosphoprotein is Selectively Expressed in Cells Competent for Self-Renewal. Cancer Res. 53:4720-4726, 1993.

  23. Epner, D. E., Partin, A. W., Schalken, J. A., Isaacs, J. T. and Coffey, D.S Association of Glyceraldehyde-3-phosphate Dehydrogenase Expression with Cell Motility and Metastatic Potential of Rat Prostatic Adenocarcinoma. Cancer Res. 53:1995-1997, 1993.

  24. Partin, A. W., Getzenberg, R. H., CarMichael, M. J., Vindivich, D., Yoo, J., Epstein, J. I. and Coffey, D.S Nuclear Matrix Protein Patterns in Human Benign Prostatic Hyperplasia and Prostate Cancer. Cancer Res. 53:744-746, 1993.

  25. Isaacs, W. B. and Coffey, D.S Understanding DNA Changes in Urological Cancers. IN: Oncogenes and Molecular Genetics of Urological Tumors (Olsson, C. A., Ed.), Churchill Livingstone, New York, pp. 3-14, 1992.

  26. PIenta, K. J. and Coffey, D.S Nuclear-cytoskeletal interactions: Evidence for Physical Connections Between the Nucleus and Cell Periphery and their Alteration by Transformation. J. Cell. Biochem. 49:357-365, 1992.

  27. Partin, A. W., Carter, H. B., Epstein, J. I. and Coffey, D.S The Biology of Prostate Cancer: New and Future Directions in Predicting Tumor Behavior. United States and Canadian Academy of Pathology: The Long Course - Urinary Bladder and Prostate, 1992.

  28. Sharma, O. P., Adlercreutz, H., Strandberg, J. D., Zirkin, B. R., Coffey, D.S and Ewing, L. L. Soy of Dietary Source Plays a Preventive Role Against the Pathogenesis of Prostatitis in Rats. J. Steroid Biochem. Mol. Biol. 43:557-546, 1992.

  29. Murphy, B. C., Pienta, K. J. and Coffey, D.S Effects of Extracellular Matrix Components and Dihydrotestosterone on the Structure and Function of Human Prostate Cancer Cells. Prostate 20:29-41, 1992.

  30. Pienta, K. J., Getzenberg, R. H. and Coffey, D.S Characterization of Nuclear Morphology and Nuclear Matrices in Ageing Human Fibroblasts. Mech. Ageing and Develop. 62:13-24, 1992.

  31. Pienta, K. J., Murphy, B. C., Isaacs, W. B., Isaacs, J. T. and Coffey, D.S Effect of Pentosan, a Novel Cancer Chemotherapeutic Agent, on Prostate Cancer Cell Growth and Motility. Prostate 20:233-241, 1992.

  32. Leonard, M. P., Jeffs, R. D., Gearhart, J. P. and Coffey, D.S Recombinant human tumor necrosis factor enhances radiosensitivity and improves animal survival in murine neuroblastoma. J. Urol. 148:743-746, 1992.

  33. Partin, A. W., Steinberg, G. D., Pitcock, R. V., Wu, L., Piantadosi, S., Coffey, D.S and Epstein, J. I. Use of Nuclear Morphometry, Gleason Histologic Scoring, Clinical Stage, and Age to Predict Disease-Free Survival Among Patients with Prostate Cancer. Cancer 70:162-168, 1992.

  34. Partin, A. W., Carter, H. B., Epstein, J. I. and Coffey, D.S The Biology of Prostate Cancer: New and Future Directions in Predicting Tumor Behavior. IN: Pathology and Pathobiology of the Urinary Bladder and Prostate (Weinstein, R. S. and Gardner, W. A., Jr., Eds.), Williams & Wilkins, pp. 198-218, 1992.

  35. Coffey, D.S The Molecular Biology, Endocrinology, and Physiology of the Prostate and Seminal Vesicles. IN: Campbell's Urology (Walsh, P. C., Retik, A. B., Stamey, T. A. and Vaughan, E. D., Jr., Eds.), W. B. Saunders Co., New York, 6th Edition, Volume I, pp. 221-266, 1992.

  36. Partin, A. W., Mohler, J. L. and Coffey, D.S Cell Motility as an Index of Metastatic Ability in Prostate Cancers: Results with an Animal Model and with Human Cancer Cells. IN: Therapy for Genitourinary Cancer (Lepor, H. and Lawson, R. K., Eds.), Kluwer Academic Publishers, pp. 121-130, 1992.

  37. Mohler, J. L., Partin, A. W., Epstein, J. I., Becker, R. L., Mikel, U. V., Sesterhenn, I. A., Mostofi, F. K., Gleason D. F., Sharief, Y. and Coffey, D.S Prediction of Prognosis in Untreated Stage A2 Prostatic Carcinoma. Cancer 69:511-519, 1992.

  38. Isaacs, W. B. and Coffey, D.S Molecular Biology of the Cancer Cell. AUA Update Series, Volume XI, Lesson 16, pp. 120-125, 1992.

  39. Coffey, D.S, Ripoll, E., Sugimura, Y. and van Steenbrugge, G.J. Animal Models of Benign Prostatic Hyperplasia. IN: The International Consultation on Benign Prostatic Hyperplasia (BPH) (Cockett, A.T.K., Aso, Y., Chatelain C., Denis, L., Griffiths, K., Khoury, S. and Murphy, G. (Eds.), Proceedings of the World Health Organization Meeting, Paris, June 27-27, pp. 269-277, 1991.

  40. Getzenberg, R. H., Pienta, K. J., Ward, S. W. and Coffey, D.S Nuclear Structure and the Three-Dimensional Organization of DNA. J. Cell. Biochem. 47:289-299, 1991.

  41. Getzenberg, R. H., Pienta K .J., Huang, E. Y. W. and Coffey, D.S Identification of Nuclear Matrix Proteins in the Cancer and Normal Rat Prostate. Cancer Res. 51:6514-6520, 1991.

  42. Pienta, K. J., Getzenberg, R.H. and Coffey, D.S Cell Structure and DNA Organization. Critical Revs. In Eukaryotic Gene Exp. 1:355-385, 1991.

  43. Getzenberg, R. H., Pienta, K. J., Huang, E. Y. W., Murphy, B. C. and Coffey, D.S Modifications of the Intermediate Filament and Nuclear Matrix Networks by the Extracellular Matrix. Biochem. Biophys. Res. Commun. 179:340-344, 1991.

  44. Pienta, K. J., Murphy, B. C., Getzenberg, R. H. and Coffey, D.S The Effect of Extracellular Matrix Interactions on Morphologic Transformation in Vitro. Biochem. Biophys. Res. Commun. 179:333-339, 1991.

  45. Pienta, K. J., Partin, A. W. and Coffey, D.S Cell Motility and Structural Harmonics in Prostate Cancer. IN: Molecular and Cell Biology of Prostate Cancer (Karr, J. P., Coffey, D.S, Smith, R. G. and Tindall, D. J., Eds.), Plenum Press, New York, pp. 65-72, 1991.

  46. Getzenberg, R. H. and Coffey, D.S Tissue Specificity and Cell Death are Associated with Specific Alterations in Nuclear Matrix Proteins. IN: Molecular and Cell Biology of Prostate Cancer (Karr, J. P., Coffey, D.S, Smith, R. G. and Tindall, D. J., Eds.), Plenum Press, New York, pp. 1-13, 1991.

  47. Hildebrand, R. K., Naslund, M. J., Oesterling, J. R. and Coffey, D.S Influence of Age, Strain, and the Testes on Rat Prostate Hormone Sensitivity. Prostate 18:81-19, 1991.

  48. Karr, J. P., Coffey, D.S, Smith, R. G. and Tindall, D. J. (Eds.), Molecular and Cellular Biology of Prostate Cancer, Plenum Press, New York, 1991.

  49. Boyd, J., Pienta, K. J., Getzenberg, R. H., Coffey, D.S and Barrett, J. C. Preneoplastic Alterations in Nuclear Morphology that Accompany Loss of Tumor Suppressor Phenotype. J. Natl. Cancer Inst. 83:862-866, 1991.

  50. Getzenberg, R. H. and Coffey, D.S Tissue Specificity of the Hormonal Response in Sex Accessory Tissues is Associated with Nuclear Matrix Protein Patterns. Mol. Endocrinol. 4:1336-1342, 1990.

  51. Ward, W. S. and Coffey, D.S DNA Packaging and Organization in Mammalian Spermatozoa: Comparison with Somatic Cells. Biol. Reprod. 44:569-574, 1991.

  52. Pienta, K. J., Isaacs, W. B., Vindivich, D. and Coffey, D.S The Effects of Basic Fibroblast Growth Factor and Suramin on Cell Motility and Growth of Rat Prostate Cancer Cells. J. Urol. 145:199-202, 1991.

  53. Pienta, K. J. and Coffey, D.S Cellular Harmonic Information Transfer Through a Tissue Tensegrity-Matrix System. Med. Hypothesis . 34:88-95, 1991.

  54. Isaacs, W. B., Isaacs, J. T., Kyprianou, N., Burgers, J. K., Alexander, R. B., Partin, A. W., Mohler, J. L., Marshall, F. F. and Coffey, D.S New Approaches to the Evaluation of the Metastatic Ability of Renal Cancer and New Approaches to Chemotherapy. Europ. Urol. 18(Suppl 2):33-35, 1990.

  55. Pienta, K. J. and Coffey, D.S Characterization of the Subtypes of Cell Motility in Ageing Human Skin Fibroblasts. Mech. Ageing Develop. 56:99-105, 1990.

  56. Ward, W. S. and Coffey, D.S Specific Organization of Genes in Relation to the Sperm Nuclear Matrix. Biochem. Biophys. Res. Commun. 173:20-25, 1990.

  57. Getzenberg, R. H., Pienta, K. J. and Coffey, D.S The Tissue Matrix: Cell Dynamics and Hormone Action. Endocrine Revs. 11:399-417, 1990.

  58. Carter, H. B. and Coffey, D.S The Prostate: An Increasing Medical Problem. Prostate 16:39-48, 1990.

  59. Coffey, D.S The Function and Control of the Prostate Gland and the Sex Accessory Tissues. In: Urology, Prostate Cancer (Khoury, S., Chatelain, C., Murphy, G. and Denis, L., Eds.), FIIS et RGP, pp. 70-103, 1990. (English version -1990; French version, 1988.)

  60. Isaacs, J. T. and Coffey, D.S Animal Model Systems for the Study of Prostatic Cancer. In: Scientific Foundations of Urology, 3rd Edition (Chisholm, G. D. and Fair, W. F., Eds.), Heinemann Medical Books (Oxford) and Year Book Medical Publishers (Chicago), pp. 613-620, 1990.

  61. Coffey, D.S and Walsh, P. C. Clinical and Experimental Studies of Benign Prostatic Hyperplasia. Urologic Clin. North Am. 17:461-475, 1990.

  62. Pienta, K. J. and Coffey, D.S DNA Organization in the Interphase Nucleus and Metaphase Chromosome. IN: Trends in Chromosome Research (Sharma, T, Ed.), Narosa Publishing House, New Delhi, pp. 1-5, 1990.

  63. Coffey, D.S and Carter, H. B. Advanced Prostatic Cancer. IN: Current Trends and Controversies: The Treatment of Prostatic Cancer. Proceedings of Symposium on Treatment of Prostate Cancer, Toronto, Sept. 24, 1988. MES Medical Education Services, Canada, pp. 21-33, 1989.

  64. Coffey, D.S and Carter, H. B. New Frontiers in The Treatment of Prostatic Cancer. IN: Current Trends and Controversies: The Treatment of Prostatic Cancer. Proceedings of Symposium on Treatment of Prostate Cancer, Toronto, Set. 24, 1988. MES Medical Education Services, Canada, pp. 2-3, 1989.

  65. Catalona, W. J., Coffey, D.S and Karr, J. P. (Eds.), Clinical Aspects of Prostate Cancer. Assessment of New Diagnostic and Management Procedures. Proceedings of a Workshop of the Prostate Cancer Working Group of the National Cancer Institute's Organ Systems Program, held Oct. 16-19, 1988 at Prout's Neck, Maine, Elsevier, N.Y., 1989.

  66. Coffey, D.S El Control Endocrino del Cancer de Prostata. IN: Actualizaciones Urologicas (Pontes, J. E., Ed.), Pulso Ediciones S.A., pp. 13-24, 1989.

  67. Partin, A. W., Pitcock, R. V., Walsh, A. C., Mohler, J. L. and Coffey, D.S Fourier Analysis of Cell Motility: Correlation of Motility with Metastatic Potential in the Dunning R3327 Animal Model of Prostate Cancer. IN: Prognostic Cytometry and Cytopathology of Prostate Cancer (Karr, J. P., Coffey, D.S and Gardner, W. Jr., Eds.), Elsevier Publ. Co., pp. 1-18, 1989.

  68. Carter, H. B., Partin, A. W. and Coffey, D.S Prediction of Metastatic Potential in an Animal Model of Prostate Cancer: Flow Cytometric Quantification of Cell Surface Charge. J. Urol. 142:1338-1341, 1989.

  69. Ward, W. S. and Coffey, D.S Identification of a Sperm Nuclear Annulus: A Sperm DNA Anchor. Biol. Reprod. 41:361-370, 1989.

  70. Ward, W. S., Partin, A. W. and Coffey, D.S DNA Loop Domains in Mammalian Spermatozoa. Chromosoma 98:153-159, 1989.

  71. Partin, A. W., Walsh, A. C., Pitcock, R. V., Mohler, J. L., Epstein, J. I. and Coffey, D.S A Comparison of Nuclear Morphometry and Gleason Grade as a Predictor of Prognosis in Stage A2 Prostate Cancer: A Critical Analysis. J. Urol. 142:1254-1258, 1989.

  72. Isaacs, J. T. and Coffey, D.S Etiology and Disease Process of Benign Prostatic Hyperplasia. Prostate (Suppl.) 2:33-50, 1989.

  73. Pienta, K. J., Partin, A. W. and Coffey, D.S Cancer as a Disease of DNA Organization and Dynamic Cell Structure. Cancer Res. 49:2525-2532, 1989.

  74. Coffey, D.S Physiologie de la Prostate. IN: Urologie - Cancer de la Prostate (Khoury, S. and Chatelain, Eds.), FIIS et RGP, 1988.

  75. Partin, A. W., Schoeniger, J. S., Mohler, J. L. and Coffey, D.S Fourier Analysis of Cell Motility: Correlation of Motility with Metastatic Potential. Proc. Natl. Acad. Sci. USA 86:1254-1258, 1989.

  76. Juniewicz, P. E., Ewing, L. L., Dahnert, W. F., Hamper, U. M., Dembeck, C., Sanders, R. C. and Coffey, D.S Determination of Canine Prostatic Size In Situ: Comparison of Direct Caliper Measurement with Radiologic and Transrectal Ultrasonographic Measurements. Prostate 14:55-64, 1989.

  77. Mohler, J. L., Partin, A. W. and Coffey, D.S Cancer Cell Motility: A Visual Grading System for Assessment of Prognosis in Prostatic Carcinoma. IN: Prognostic Cytometry and Cytopathology of Prostate Cancer (Karr, J. P., Coffey, D.S and Gardner, W., Jr., Eds.), Elsevier Science Publishing Co., Inc., pp. 337-348, 1989.

  78. Carter, H. B. and Coffey, D.S Prediction of Tumor Behavior in Prostate Cancer. IN: Prostate Cancer: The Second Tokyo Symposium (Karr, J. P. and Yamanaka, H., Eds.), Elsevier Science Publishing Co., Inc., pp. 19-27, 1989.

  79. Partin, A. W., Isaacs, J. T., Treiger, B. and Coffey, D.S Early Cell Motility Changes Associated with an Increase in Metastatic Ability in Rat Prostatic Cancer Cells Transfected with the v-Harvey-ras Oncogene. Cancer Res. 48:6050-6053, 1988.

  80. Naslund, M. J., Strandberg, J. D. and Coffey, D.S The Role of Androgens and Estrogens in the Pathogenesis of Experimental Nonbacterial Prostatitis. J. Urol. 140:1049-1053, 1988.

  81. Mohler, J. L., Partin, A. W., Isaacs, J. T. and Coffey, D.S Metastatic Potential by a Visual Grading System of Cell Motility: Prospective Validation in the Dunning R-3327 Prostatic Adenocarcinoma. Cancer Res. 48:4312-4317, 1988.

  82. Schulze, H., Oesterling, J.E., Isaacs, J.T. and Coffey, D.S. Hormonal Therapy of Prostate Cancer: Limitations in the Total Androgen Ablation Concept. IN: A Multidisciplinary Analysis of Controversies in the Management of Prostate Cancer (Coffey, D.S., Resnick, M.I., Dorr, F.A. and Karr, J.P., Eds.), Plenum Press, New York, 1988, pp. 215-224.

  83. Carter, H.B. and Coffey, D.S. Prostate Cancer: The Magnitude of the Problem in the United States. IN: A Multidisciplinary Analysis of Controversies in the Management of Prostate Cancer (Coffey, D.S., Resnick, M.I., Dorr, F.A. and Karr, J.P., Eds.), Plenum Press, New York, 1988, pp. 1-8.

  84. Carter, H. B. and Coffey, D.S Cell Surface Charge in Predicting Metastatic Potential of Aspirated Cells from the Dunning Rat Prostatic Adenocarcinoma Model. J. Urol. 140:173-175, 1988.

  85. Oesterling, J. E., Juniewicz, P. E., Walters, J. R., Strandberg, J. D., Steele, R. E., Ewing, L. L. and Coffey, D.S Aromatase Inhibition in the Dog. II. Effect on Growth, Function, and Pathology of the Prostate. J. Urol. 139:832-839, 1988.

  86. Juniewicz, P. E., Oesterling, J. E., Walters, J. R., Steele, R. E., Niswender, G. D., Coffey, D.S and Ewing, L. L. Aromatase Inhibition in the Dog. I. Effect on Serum LH, Serum Testosterone Concentrations, Testicular Secretions, and Spermatogenesis. J. Urol. 139:827-831, 1988.

  87. Mohler, J. L., Partin, A. W., Epstein, J. I., Lohr, W. D. and Coffey, D.S Nuclear Roundness Factor Measurement for Assessment of Prognosis of Patients with Prostatic Carcinoma. II. Standardization of Methodology for Histologic Sections. J. Urol. 139:1085-1090, 1988.

  88. Mohler, J. L., Partin, A. W., Lohr, W. D. and Coffey, D.S Nuclear Roundness Factor Measurement for Assessment of Prognosis of Patients with Prostatic Carcinoma. I. Testing of a Digitization System. J. Urol. 139:1080-1084, 1988.

  89. Coffey, D.S Androgen Action and the Sex Accessory Tissues. IN: The Physiology of Reproduction (Knobil, E., Neill, J. D., Ewing, L. L., Greenwald, G. S., Markert, C. L. and Pfaff, D. W., Eds.), Raven Press, New York, 1988, pp. 1081-1120.

  90. Isaacs, J. T., Schulze, H. and Coffey, D.S Development of Androgen Resistance in Prostatic Cancer. IN: Prostate Cancer, Part A. Research, Endocrine Treatment, and Histopathology: Progress in Clinical and Biological Research, Vol. 243A (Murphy, G., Khoury, S., Kuss, R., Chatelain, C. and Denis, L., eds.), Alan R. Liss, New York, 1987, pp. 21-31.

  91. Schulze, H., Isaacs, J. T. and Coffey, D.S A Critical Review of the Concept of Total Androgen Ablation in the Treatment of Prostate Cancer. IN: Prostate Cancer, Part A. Research, Endocrine Treatment, and Histopathology: Progress in Clinical and Biological Research, Vol. 243A (Murphy, G., Khoury, S., Kuss, R., Chatelain, C. and Denis, L., eds.), Alan R. Liss, New York, 1987, pp. 1-19.

  92. Juniewicz, P. E., Oesterling, J. E., Walters, J. R., Strandberg, J. D., Coffey, D.S and Ewing, L. L. Effect of Aromatase Inhibition on Prostatic Growth and Pathology, Prostatic and Serum Androgen Concentrations, and Testicular Androgen Secretion in Beagles. Steroids 50:4-6, 1987.

  93. Juniewicz, P. E., Walters, J. R., Oesterling, R. E., Coffey, D.S and Ewing, L. L. Effect of Inhibiting Endogenous Estradiol Production on Androgen Secretion by Dog Testes Perfused in Vitro. Reprinted from Cell Biology of the Testis and Epididymis, Volume 513 of the Annals of the New York Academy of Sciences, December 29, 1987.

  94. Coffey, D.S and Pienta, K. J. New Concepts in Studying the Control of Normal and Cancer Growth of the Prostate. IN: Current Concepts and Approaches to the Study of Prostate Cancer (Coffey, D.S, Bruchovsky, N., Gardner, W. A., Resnick, M. I. and Karr, J. P., Eds.), Alan R. Liss, Inc., New York, 1987, pp. 1-73

  95. Naslund, M. J. and Coffey, D.S The Hormonal Imprinting of the Prostate and the Regulation of Stem Cells in Prostatic Growth. IN: Benign Prostatic Hyperplasia, Vol. II (Rodgers, D.S., Coffey, D.S. Cunha, g., Grayhack, J.T., Hinman, F., Jr. and Horton, R., Eds.), U.S. Dept. of Health and Human Services, 1987, pp. 73-83, NIH Publication No. 87-2881, 1987.

  96. Coffey, D.S, Berry, S. J. and Ewing, L. L. An Overview of Current Concepts in the Study of Benign Prostatic Hyperplasia. IN: Benign Prostatic Hyperplasia, Vol. II (Rodgers, C. H., Coffey, D.S, Cunha, G., Grayhack, J. T., Hinman, F., Jr. and Horton, R., Eds.), U.S. Dept. of Health and Human Services, 1987, pp. 1-13, NIH Publication No. 87-2881, 1987.

  97. Ewing, L. L., Berry, S. J., Juniewicz, P. E., Zirkin, B. R. and Coffey, D.S Aging, Leydig Cell Structure-Function and Benign Prostatic Hyperplasia in the Beagle. IN: Benign Prostatic Hyperplasia, Vol. II (Rodgers, C. H., Coffey, D.S, Cunha, G., Grayhack, J. T., Hinman, F., Jr. and Horton, R., Eds.), U.S. Dept. of Health and Human Services, 1987, pp. 129-137, NIH Publication No. 87-2881, 1987.

  98. Nelson, W. G. and Coffey, D.S Structural Aspects of Mammalian DNA Replication: Topoisomerase II. NCI Monographs 4:23-29, 1987.

  99. Alexander, R. B. and Coffey, D.S Future Developments and New Research in Genitourinary Cancers - Perspectives. Cancer 60:686-690, 1987.

  100. Mohler, J . L., Partin, A. W. and Coffey, D.S Correlation of Prognosis to Nuclear Roundness and to Flow Cytometric Light Scatter. Anal. Quant. Cytol. Histol. 9:156-164, 1987.

  101. Alexander, R. B., Nelson, W. G. and Coffey, D.S Synergistic Enhancement by Tumor Necrosis Factor of in Vitro Cytotoxicity from Chemotherapeutic Drugs Targeted at DNA Topoisomerase II. Cancer Res. 47:2403-2406, 1987.

  102. Nelson, W. G., Cho, K. R., Hsiang, Y.-H., Liu, L. F. and Coffey, D.S Growth-related Elevations of DNA Topoisomerase II Levels Found in Dunning R3327 Rat Prostatic Adenocarcinomas. Cancer Res. 47:3246-3250, 1987.

  103. Alexander, R. B., Isaacs, J. T. and Coffey, D.S Tumor Necrosis Factor Enhances the In Vitro and In Vivo Efficacy of Chemotherapeutic Drugs Targeted at DNA Topoisomerase II in the Treatment of Murine Bladder Cancer. J. Urol. 138:427-429, 1987.

  104. Mohler, J. L., Partin, A. W. and Coffey, D.S Prediction of Metastatic Potential by a New Grading System of Cell Motility: Validation in the Dunning R-3327 Prostatic Adenocarcinoma Model. J. Urol. 138:168-170, 1987.

  105. Mohler, J. L., Partin, A. W., Isaacs, W. B. and Coffey, D.S Time Lapse Videomicroscopic Identification of Dunning R-3327 Adenocarcinoma and Normal Rat Prostate Cells. J. Urol. 137:544-547, 1987.

  106. Bartsch, G., Bruengger, A., DeKlerk, D. P., Coffey, D.S and Rohr, H. P. Light-Microscopic Stereologic Analysis of Spontaneous and Steroid-Induced Canine Prostatic Hyperplasia. J. Urol. 137:552-558, 1987.

  107. Berry, S. J., Coffey, D.S and Ewing, L. L. Effects of Aging on Prostate Growth in Beagles. J. Am. Physiol. Soc. 250 (Regulatory Integrative Comp. Physiol. 19):R1039-R1046, 1986.

  108. Berry, S. J., Strandberg, J. D., Saunders, W. J. and Coffey, D.S Development of Canine Benign Prostatic Hyperplasia With Age. Prostate 9:363-373, 1986.

  109. Naslund, M. J. and Coffey, D.S The Differential Effects of Neonatal Androgen, Estrogen and Progesterone on Adult Rat Prostate Growth. J. Urol. 136:1136-1140, 1986.

  110. Berry, S. J., Coffey, D.S, Strandberg, J. D. and Ewing, L. L. Effect of Age, Castration, and Testosterone Replacement on the Development and Restoration of Canine Benign Prostatic Hyperplasia. Prostate 9(3):295-302, 1986.

  111. Coffey, D.S Endocrine Control of Normal and Abnormal Growth of the Prostate. IN: Urologic Endocrinology (Rajfer, J., Ed.), W. B. Saunders Co., Philadelphia, 1986, pp. 170-195.

  112. Nelson, W. G., Liu, L. F. and Coffey, D.S Newly Replicated DNA is Associated with DNA Topoisomerase II in Cultured Rat Prostatic Adenocarcinoma Cells. Nature 322:187-189, 1986.

  113. Nelson, W. G., Pienta, K. J., Barrack, E. R. and Coffey, D.S The Role of the Nuclear Matrix in the Organization and Function of DNA. IN: Annual Review of Biophysics and Biophysical Chemistry, Vol. 15 (Engelman, D. M., Cantor, C. R. and Pollard, T. D., Eds.), Annual Reviews Inc., Palo Alto, California, 1986, pp. 457-475.

  114. Simons, J. W., Noga, S. J., Colombani, P. M., Beschorner, W. E., Coffey, D.S and Hess, A. D. Cyclosporine A, an In Vitro Calmodulin Antagonist, Induces Nuclear Lobulations in Human T Cell Lymphocytes and Monocytes. J. Cell Biol. 102:145-150, 1986.

  115. Berry, S. J., Sterner, R., Coffey, D.S and Ewing, L. L. Methods for Monitoring Canine Prostate Size: Internal and External Caliper Measurements. Prostate 6(3):303, 1985.

  116. Pienta, K. J. and Coffey, D.S The Nuclear Matrix: An Organizing Structure for the Interphase Nucleus and Chromosome. IN: Structure and Function of the Genetic Apparatus. Proceedings of a NATO Advanced Study Institute held September 18-30, 1983 in Erice, Italy (Nicolini, C. and Ts'o, P., Eds.), Plenum Press, New York, 1985, pp. 83-98.

  117. Simons, J. W., Noga, S. J., Colombani, P. M., Coffey, D.S and Hess, A. H. Cyclosporine Induces Alteration in the Nuclear Morphology of Human Mononuclear Leukocytes. IN: Nuclear Envelope and RNA Maturation. UCLA Symposia on Molecular and Cellular Biology New Series, Vol. 26. Proceedings of a Symposium held in Steamboat Springs, Colorado, January 12-19, 1985 (Smuckler, E. A. and Clawson, G. A., Eds.), Alan R. Liss, New York, 1985, pp. 125-136.

  118. Coffey, D.S The Biochemistry and Physiology of the Prostate and Seminal Vesicles. IN: Campbell's Urology, Vol. 1, 5th Edition (Walsh, P. C., Gittes, R. F., Perlmutter, A. D. and Stamey, T. A., Eds.), W. B. Saunders Co., Philadelphia, pp. 233-274, 1986.

  119. Berry, S. J., Coffey, D.S and Ewing, L. L. A Comparison of Human and Canine Benign Prostatic Hyperplasia. IN: Regulation of Androgen Action. Proceedings of an International Symposium, Montreal, 1984 (Bruchovsky, N., Chapdelaine, A. and Neumann, F., Eds.), Congressdruck R. Bruckner, Berlin (West), pp. 59-68, 1985.

  120. Pienta, K. J. and Coffey, D.S A Structural Analysis of the Role of the Nuclear Matrix and DNA Loops in the Organization of the Nucleus and Chromosome. J. Cell Science Suppl. 1:123-135, 1984.

  121. Benson, M. C., McDougal, D. C. and Coffey, D.S The Application of Perpendicular and Forward Light Scatter to Assess Nuclear and Cellular Morphology. Cytometry 5:515, 1985.

  122. Berry, S. J., Coffey, D.S, Walsh, P. C. and Ewing, L. L. The Development of Human Benign Prostatic Hyperplasia With Age. J. Urol. 132:474, 1984.

  123. Isaacs, W. B. and Coffey, D.S The Predominant Protein of Canine Seminal Plasma Is An Enzyme. J. Biol. Chem. 259:11520, 1984.

  124. Benson, M. C. and Coffey, D.S New Concepts and Controversies Concerning Prostate Cancer. IN: Progress and Controversies in Oncological Urology, Alan R. Liss, New York, pp. 547-562, 1984.

  125. Benson, M. C., McDougal, D. C. and Coffey, D.S The Use of Multiparameter Flow Cytometry to Assess Tumor Cell Heterogeneity and Grade Prostate Cancer. Prostate 5:27, 1984.

  126. Coffey, D.S The Role of Tumor Cell Heterogeneity in Controlling Prostate Cancer. IN: Proceedings of the Meeting of the Dutch Association of Urology, The Netherlands, (de Voogt, H.J., Ed.), pp. 37-42, 1983.

  127. Barrack, E. R. and Coffey, D.S The Role of Nuclear Structure in Hormone Action: The Nuclear Matrix. IN: Steroid Hormones Receptors: Structure and Function. Proceedings of Nobel Symposium No. 57 (Eriksson, H. and Gustafsson, J.-A., Eds.), Elsevier Science Publishers, Amsterdam, pp. 221-229, 1983.

  128. Diamond, D. A., Berry, S. J., Jewett, H. J., Eggleston, J. C. and Coffey, D.S A New Method to Assess Metastatic Potential of Human Prostate Cancer: Relative Nuclear Roundness. IN: Year Book of Urology - 1983 (Gillenwater, J. Y. and Howards, S. S., Eds.), Year Book Medical Publishers, Chicago/London, 1983. (Abstract of article appearing as full manuscript in J. Urol. 128:729, 1982.)

  129. Benson, M. C. and Coffey, D.S Prostate Cancer Research: Current Concepts and Controversies. Seminars in Urology 1:323, 1983.

  130. Barrack, E. R. and Coffey, D.S Hormone Receptors and the Nuclear Matrix. IN: Gene Regulation by Steroid Hormones II (Roy, A. K. and Clark, J. H., Eds.), Springer-Verlag, New York, pp. 239-266, 1983.

  131. Isaacs, J. T. and Coffey, D.S Model Systems for the Study of Prostatic Cancer. IN: Clinics in Oncology, Vol. 2 (Murphy, G. P., Ed.), W. B. Saunders Co. Ltd., London, pp. 479-498, 1983.

  132. Coffey, D.S The Concept of DNA Rearrangement in Carcinogenesis: The Nuclear Matrix. IN: Genes and Proteins in Oncogenesis (Weinstein, I. B. and Vogel, H. J., Eds.), Academic Press, New York, pp. 339-349, 1983.

  133. Brendler, C. B., Berry, S. J., Ewing, L. L., McCullough, A. R., Cochran, R. C., Strandberg, J. D., Zirkin, B. R., Coffey, D.S, Wheaton, L. G., Hiler, M. L., Bordy, M. J., Niswender, G. D., Scott, W. W. and Walsh, P. C. Spontaneous Benign Prostatic Hyperplasia in the Beagle. J. Clin. Invest. 71:1114, 1983.

  134. Barrack, E. R. and Coffey, D.S The Role of the Nuclear Matrix in Steroid Hormone Action. IN: Biochemical Actions of Hormones, Vol. X, Academic Press, New York, pp. 23-90, 1983.

  135. Owens, A. H., Coffey, D.S and Baylin, S. B. Tumor Cell Heterogeneity. Origins and Implications. Bristol-Myers Cancer Symposia, Vol. 4, (Owens, A. H., Coffey, D.S and Baylin, S. B., Eds.), Academic Press, New York, 1982.

  136. Diamond, D. A., Berry, S. J., Jewett, H. J., Eggleston, J. C. and Coffey, D.S A New Method to Assess Metastatic Potential of Human Prostate Cancer: Relative Nuclear Roundness. J. Urol. 128:729, 1982.

  137. Isaacs, J. T., Wake, N., Coffey, D.S and Sandberg, A. A. Genetic Instability Coupled to Clonal Selection as a Mechanism for Tumor Progression in the Dunning R-3327 Rat Prostatic Adenocarcinoma System. Cancer Res. 42:2353, 1982.

  138. Diamond, D. A., Berry, S. J., Umbricht, C., Jewett, H. J. and Coffey, D.S Computerized Image Analysis of Nuclear Shape as a Prognostic Factor for Prostatic Cancer. Prostate 3(4):321, 1982.

  139. Isaacs, J. T. and Coffey, D.S Animal Models in the Study of Prostatic Growth. IN: Scientific Foundations of Urology, Second Edition (Chisholm, G. D. and Williams, D. I., Eds.), William Heinemann Medical Books Ltd., London, pp. 743-754, 1982.

  140. Feinberg, A. P. and Coffey, D.S The Concept of DNA Rearrangement in Carcinogenesis and Development of Tumor Cell Heterogeneity. IN: Tumor Cell Heterogeneity. Origins and Implications. Bristol-Myers Cancer Symposia, Vol. 4 (Owens, A. H., Coffey, D.S and Baylin, S. B., Eds.), Academic Press, New York, pp. 469-488, 1982.

  141. Feinberg, A. P. and Coffey, D.S Organ Site Specificity for Cancer in Chromosomal Instability Disorders. Cancer Res. 42:3252, 1982.

  142. Barrack, E. R. and Coffey, D.S Biological Properties of the Nuclear Matrix: Steroid Hormone Binding. IN: Recent Progress in Hormone Research, Vol. 38 (Greep, R. O., Ed.), Academic Press, New York, pp. 133-195, 1982.

  143. Feinberg, A. P. and Coffey, D.S The Topology of DNA Loops: A Possible Link Between the Nuclear Matrix Structure and Nucleic Acid Function. IN: The Nuclear Envelope and the Nuclear Matrix (Maul, G. G., Ed.), Alan R. Liss, New York, pp. 293-305, 1982.

  144. Isaacs, J. T. and Coffey, D.S Androgen Metabolism in the Prostate: New Concepts Related to Normal and Abnormal Growth. IN: Antihormone. Bedeutung in der Urologie (Altwein, J. E., Bartsch, G. and Jacobi, G. H., Eds.), W. Zuckscherdt Verlag, Munchen, 1981.

  145. Isaacs, J. T. and Coffey, D.S Adaptation versus Selection as the Mechanism Responsible for the Relapse of Prostatic Cancer to Androgen Ablation Therapy as Studied in the Dunning R-3327-H Adenocarcinoma. Cancer Res. 41:5070, 1981.

  146. Isaacs, J. T., Barrack, E. R., Isaacs, W. B. and Coffey, D.S The Relationship of Cellular Structure and Function: The Matrix System. IN: The Prostatic Cell: Structure and Function (Murphy, G. P., Sandberg, A. A. and Karr, J. P., Eds.), Part A, Alan R. Liss, New York, pp. 1-24, 1981.

  147. Pardoll, D. M., Vogelstein, B. and Coffey, D.S A Fixed Site of DNA Replication in Eucaryotic Cells. IN: Readings in Mammalian Cell Culture (Pollack, R., Ed.), Cold Spring Laboratory, New York, 1981. (Reprinted from Cell, Vol. 19, 527-536, February, 1980, Copyright 1980 by MIT).

  148. Isaacs, J. T. and Coffey, D.S Animal Models in the Study of Prostatic Cancer. IN: Prostatic Cancer (Ablin, R. J., Ed.), Marcel Dekker, Inc., New York, pp. 61-72, 1981.

  149. Isaacs, J. T., Yu, G. W. and Coffey, D.S The Characterization of a Newly Identified, Highly Metastatic Variety of Dunning R-3327 Rat Prostatic Adenocarcinoma System: The MAT-LyLu Tumor. Invest. Urol. 19(1):20, 1981.

  150. Ehrlichman, R. J., Isaacs, J. T. and Coffey, D.S Differences in the Effects of Estradiol on Dihydrotestosterone Induced Prostatic Growth of the Castrate Dog and Rat. Invest. Urol. 18(6):466, 1981.

  151. Kaufmann, S. H., Coffey, D.S and Shaper, J. H. Considerations in the Isolation of Rat Liver Nuclear Matrix, Nuclear Envelope and Pore Complex Lamina. Exp. Cell Res. 132:105, 1981.

  152. Coffey, D.S and Isaacs, J. T. Control of Prostate Growth. Urology 17:17, 1981.

  153. Coffey, D.S and Isaacs, J. T. Prostate Tumor Biology and Cell Kinetics - Theory. Urology 17:40, 1981.

  154. Isaacs, J. T. and Coffey, D.S Changes in Dihydrotestosterone Metabolism Associated with the Development of Canine Benign Prostatic Hyperplasia. Endocrinology 108:445, 1981.

  155. Vogelstein, B., Pardoll, D. M. and Coffey, D.S Supercoiled Loops and Eucaryotic DNA Replication. Cell 22:79, 1980.

  156. Rohr, H. P., Coffey, D.S, DeKlerk, D. P., Woodtli, H. P. and Bartsch, G. The Dog Prostate Under Defined Hormonal Influences: An Approach to Experimental Induced Prostatic Growth. Path. Res. Pract. 166:347, 1980.

  157. Barrack, E. R. and Coffey, D.S The Specific Binding of Estrogens and Androgens to the Nuclear Matrix of Sex Hormone Responsive Tissues. J. Biol. Chem. 255(15):7265, 1980.

  158. Isaacs, J. T., Isaacs, W. B., Wheaton, L. G. and Coffey, D.S Differential Effects of Estrogen Treatment on Canine Seminal Plasma Components. Invest. Urol. 17(6):495, 1980.

  159. Isaacs, J. T., McDermott, I. R. and Coffey, D.S The Identification and Characterization of the C19O3 Metabolites of 5 -Androstane-3 ,17 -Diol Produced by the Canine Prostate: 5 -Androstane-3 ,6 ,17 -Triol and 5 -Androstane-3 ,7 ,17 -Triol. Steroids 35(2):139, 1980.

  160. Isaacs, J. T., Weissman, R. M., Coffey, D.S and Scott, W. W. Concepts in Prostatic Cancer Biology: Dunning R-3327-H, HI and AT Tumors. IN: Models for Prostate Cancer (Ablin, R. J. and Nieburgs, H. E., Eds.), Alan R. Liss, Inc., New York, pp. 311-323, 1980.

  161. Coffey, D.S and Isaacs, J. T. Requirements for an Idealized Animal Model of Prostatic Cancer. IN: Models for Prostate Cancer (Ablin, R. J. and Nieburgs, H. E., Eds.), Alan R. Liss, Inc., New York, pp. 379- 391, 1980.

  162. Pardoll, D. M., Vogelstein, B. and Coffey, D.S Fixed Site of DNA Replication in Eucaryotic Cells. Cell 19:527, 1980.

  163. Isaacs, J.T. and Coffey, D.S. Animal Models in the Study of Prostatic Cancer. Cancer Detection and Prevention, 2:587-599, 1979.

  164. Rajfer, J. and Coffey, D.S Effects of Neonatal Steroids on Male Sex Tissues. Invest. Urol. 17:13, 1979.

  165. Coffey, D.S and Isaacs, J. T. Experimental Concepts in the Design of New Treatments for Human Prostatic Cancer. IN: Prostate Cancer. A Series of Workshops on the Biology of Human Cancer, Report No. 9 (Coffey, D.S and Isaacs, J. T., Eds.), International Union Against Cancer, Geneva, pp. 233-259, 1979.

  166. Isaacs, J. T. and Coffey, D.S Spontaneous Animal Models for Prostatic Cancer. IN: Prostate Cancer. A Series of Workshops on the Biology of Human Cancer, Report No. 9 (Coffey, D.S and Isaacs, J. T., Eds.), International Union Against Cancer, Geneva, pp. 195-217, 1979.

  167. Isaacs, J. T. and Coffey, D.S Androgenic Control of Prostatic Growth: Regulation of Steroid Levels. IN: Prostate Cancer. A Series of Workshops on the Biology of Human Cancer, Report No. 9 (Coffey, D.S and Isaacs, J. T., Eds.), International Union Against Cancer, Geneva, pp. 112-122, 1979.

  168. Coffey, D.S Physiological Control of Prostatic Growth: An Overview. IN: Prostate Cancer. A Series of Workshops on the Biology of Human Cancer, Report No. 9 (Coffey, D.S and Isaacs, J. T., Eds.), International Union Against Cancer, Geneva, pp. 4-15, 1979.

  169. Coffey, D.S and Isaacs, J. T. Prostate Cancer. A Series of Workshops on the Biology of Human Cancer, Report No. 9 (Coffey, D.S and Isaacs, J. T., Eds.), International Union Against Cancer, Geneva, 1979.

  170. Isaacs, J. T., Scott, W. W. and Coffey, D.S New Biochemical Methods to Determine Androgen Sensitivity of Prostatic Cancer; the Relative Enzymatic Index (REI). IN: Prostate Cancer and Hormone Receptors (Murphy, G. P. and Sandberg, A. A., Eds.), Vol. 33, Progress in Clinical and Biological Research, Alan R. Liss, Inc., New York, pp. 133-144, 1979.

  171. Weissman, R. M., Scott, W. W., Isaacs, J. T. and Coffey, D.S Concepts Related to Prostatic Cancer as Revealed by a Study of the Dunning R3327 Prostatic Adenocarcinoma Models. IN: Advances in Medical Oncology, Research and Education, Vol. 11, Clinical Cancer Principle Sites 2 (Wilkinson, P. M., Ed.), Pergamon Press, Oxford, England, pp. 313-321, 1979.

  172. Wheaton, L. G., DeKlerk, D. P., Strandberg, J. D. and Coffey, D.S Relationship of Seminal Volume to Size and Disease of the Prostate in the Beagle. Am. J. Vet. Res. 40(9):1325, 1979.

  173. DeKlerk, D. P., Coffey, D.S, Ewing, L. L., McDermott, I. R., Reiner, W. G., Robinson, C. H., Scott, W. W., Strandberg, J. D., Talalay, P., Walsh, P. C., Wheaton, L. G. and Zirkin, B. R. Comparison of Spontaneous and Experimentally Induced Canine Prostatic Hyperplasia. J. Clin. Invest. 64(3):842, 1979.

  174. Shaper, J. H., Pardoll, D. M., Kaufmann, S. H., Barrack, E. R., Vogelstein, B. and Coffey, D.S The Relationship of the Nuclear Matrix to Cellular Structure and Function. IN: Advances in Enzyme Regulation (Weber, G., Ed.), Pergamon Press, Oxford, England, Vol. 17, pp. 213-248, 1979.

  175. Barrack, E. R., Hawkins, E. F. and Coffey, D.S The Specific Binding of Estradiol to the Nuclear Matrix. IN: Steroid Hormone Receptor Systems (Leavitt, W. W. and Clark, J. H., Eds.), Plenum Publishing Corp., pp. 47-70, 1979.

  176. Isaacs, J. T., Isaacs, W. B. and Coffey, D.S Models for Development of Nonreceptor Methods for Distinguishing Androgen-Sensitive and-Insensitive Prostatic Tumors. Cancer. Res. 39:2652, 1979.

  177. Coffey, D.S, Isaacs, J. T. and Weissman, R. M. Animal Models for the Study of Prostatic Cancer. IN: Prostatic Cancer (Murphy, G. P., Ed.), PSG Publishing Co., Inc., Littleton, Mass., pp. 89-110, 1979.

  178. Weissman, R. M., Coffey, D.S and Scott, W. W. Cell Kinetic Studies of Prostatic Cancer: Adjuvant Therapy in Animal Models. IN: Karger Highlights, Reprinted Selected Top Articles Published 1976-1978. Oncology 2, Cancer Chemotherapy. S. Karger, Basel, 1979, pp. 114-118.

  179. Isaacs, J. T., McDermott, I. R. and Coffey, D.S Characterization of Two New Enzymatic Activities of the Rat Ventral Prostate: 5a-Androstane-3 ,17 -Diol 6 -Hydroxylase and 5 -Androstane-3 ,17 -Diol 7 -Hydroxylase. Steroids 33:675, 1979.

  180. Isaacs, J. T., McDermott, I. R. and Coffey, D.S The Identification and Characterization of New C19O3 Steroid Metabolite in the Rat Ventral Prostate: 5 -Androstane-3 ,6 ,17 -Triol. Steroids 33:639, 1979.

  181. Chung, L. W. K. and Coffey, D.S Androgen Glucuronide. II. Differences in its Formation by Human Normal and Benign Hyperplasia Prostates. Invest Urol. 15:385, 1978.

  182. Rajfer, J. and Coffey, D.S Sex Steroid Imprinting of the Immature Prostate - Long-Term Effects. Invest. Urol. 16:186, 1978.

  183. DeKlerk, D. P. and Coffey, D.S Quantitative Determination of Prostatic Epithelial and Stromal Hyperplasia by a New Technique - Biomorphometrics. Invest. Urol. 16:240, 1978.

  184. Coffey, D.S The Biochemistry and Physiology of the Prostate and Seminal Vesicles. IN: Campbell's Urology (Harrison, J. H., Gittes, R. F., Perlmutter, A. D., Stamey, T. A. and Walsh, P. C., Eds.), 4th Edition, Vol. 1, W. B. Saunders Co., Philadelphia, pp. 161-201, 1978.

  185. Isaacs, J. T., Heston, W. D. W., Weissman, R. M. and Coffey, D.S Animal Models of the Hormone-Sensitive and -Insensitive Prostatic Adenocarcinomas, Dunning R-3327-H, R-3327-HI, and R-3327-AT. Cancer Res. 38:4353, 1978.

  186. Weissman, R. M., Coffey, D.S and Jewett, H. J. Current Concepts in the Study of Bladder Cancer. Urological Surveys 28:1, 1978.

  187. Barrack, E. R., Hawkins, E. F., Allen, S. L., Hicks, L. L. and Coffey, D.S Concepts Related to Salt Resistant Estradiol Receptors in Rat Uterine Nuclei: Nuclear Matrix. Biochem. Biophys. Res. Commun. 79:829, 1977.

  188. Chung, L. W. K. and Coffey, D.S Androgen Glucuronides. I. Direct Formation in Rat Accessory Sex Organs. Steroids 30:223, 1977.

  189. Rajfer, J., Coffey, D.S and Walsh, P. C. Effect of Hormones in the Newborn Period on the Development of the Penis. Surgical Forum 28:570, 1977.

  190. Hagan, K. F. and Coffey, D.S The Adverse Effects of Sperm During Vasovasostomy. J. Urol. 118:269, 1977.

  191. Weissman, R. M., Coffey, D.S and Scott, W. W. Cell Kinetic Studies of Prostatic Cancer; Adjuvant Therapy in Animal Models. Oncology 34(3):133, 1977.

  192. Smolev, J. K., Coffey, D.S and Scott, W. W. Experimental Models for the Study of Prostatic Adenocarcinoma. J. Urol. 118 (No. 1, Part 2): 216, 1977.

  193. Berezney, R. and Coffey, D.S Nuclear Matrix. Isolation and Characterization of a Framework Structure from Rat Liver Nuclei. J. Cell Biol. 73:616, 1977.

  194. Smolev, J. K., Heston, W. D. W., Scott, W. W. and Coffey, D.S Characterization of the Dunning R3327H Prostatic Adenocarcinoma: An Appropriate Animal Model for Prostatic Cancer. Cancer Trtm. Rep. 61 (No. 2):272, 1977.

  195. Coffey, D.S, DeKlerk, D. P. and Walsh, P. C. Benign Prostatic Hyperplasia. Current Concepts. IN: Proceedings of the Vth International Congress of Endocrinology (James, V. H. T., Ed.), Vol. 2, Excerpta Medica International Congress Series No. 403, Amsterdam, pp. 495-499, 1977.

  196. Allen, S. L., Berezney, R. and Coffey, D.S Phosphorylation of Nuclear Matrix Proteins in Isolated Regenerating Rat Liver Nuclei. Biochem. Biophys. Res. Commun. 75:111, 1977.

  197. DeKlerk, D. P., Heston, W. D. W. and Coffey, D.S Studies on the Role of Macromolecular Synthesis in the Growth of the Prostate. IN: Benign Prostatic Hyperplasia. Proceedings of the National Institute of Arthritis, Metabolism and Digestive Diseases Workshop. D.H.E.W. Publication, U.S. Government Printing Office, Feb. 20-21, 1975, pp. 43-54, 1976.

  198. Berezney, R. and Coffey, D.S The Nuclear Protein Matrix: Isolation, Structure, and Functions. IN: Advances in Enzyme Regulation (Weber, G., Ed.), Pergamon Press, Oxford, England, Vol. 14, pp. 63-100, 1976.

  199. Zirkin, B. R., Boison, A., Heston, W. D. W. and Coffey, D.S Release of DNA Template Restrictions in Rabbit Spermatozoa and Rat Liver Nuclei. J. Exp. Zool. 197:283, 1976.

  200. Sufrin, G., Heston, W. D. W., Hazra, T. and Coffey, D.S The Effect of Radiation on Prostatic Growth. Invest. Urol. 13:418, 1976.

  201. Sufrin, G. and Coffey, D.S Flutamide - Mechanism of Action of a New Nonsteroidal Antiandrogen. Invest. Urol. 13:429, 1976.

  202. Brannen, G. E. and Coffey, D.S Serum-Mediated Immunoresponse to Spermatozoa. Invest. Urol. 13:85, 1975.

  203. Sloan, W. R., Coffey, D.S and Scott, W. W. The Effects of 5-Fluorouracil on Prostatic DNA Synthesis. Invest. Urol. 13:90, 1975.

  204. Berger, B., Coffey, D.S and Scott, W. W. Concepts and Limitations in the Application of Radiolabeled Antiandrogens, Estrogens, or Androgens as Isotopic Scanning Agents for the Prostate. Invest. Urol. 13:10, 1975.

  205. Scott, W. W. and Coffey, D.S Nonsurgical Treatment of Human Benign Prostatic Hyperplasia. IN: Vitamins and Hormones, Vol. 33, Academic Press, New York, pp. 439-465, 1975.

  206. Sufrin, G. and Coffey, D.S Differences in the Mechanism of Action of Medrogestone and Cyproterone Acetate. Invest. Urol. 13:1, 1975.

  207. Berezney, R. and Coffey, D.S Nuclear Protein Matrix: Association with Newly Synthesized DNA. Science 189:291, 1975.

  208. Heston, W. D. W., Zirkin, B. R. and Coffey, D.S Release of Chromatin Template Restriction in Rabbit Spermatozoa. Biochem. Biophys. Res. Commun. 64:162-168, 1975.

  209. Coffey, D.S and Sloan, W. R. Biochemical Changes in Prostatic Tissue Associated with DNA Synthesis. IN: Normal and Abnormal Growth of the Prostate (Goland, M., Ed.), Charles C. Thomas, Illinois, pp. 240-274, 1975.

  210. Coffey, D.S and Freeman, C. Vas Injection: A New Nonsurgical Procedure to Induce Sterility in Human Males. IN: Control of Male Fertility (Sciarra, J. J., Markland, C. and Speidel, J. J., Eds.), pp. 147-160, 1975.

  211. Sloan, W. R., Heston, W. D. W. and Coffey, D.S New Model for Studying the Effects of Cancer Chemotherapeutic Agents on the Growth of the Prostate Gland. Cancer Chemother. Rep. 59:185-194, 1975.

  212. Brannen, G. E., Gomolka, D. M. and Coffey, D.S Specificity of Cell Membrane Antigens in Prostatic Cancer. Cancer Chemother. Rep. 59:127-138, 1975.

  213. Brannen, G. E., Eggleston, J. C., Adams, J. S. and Coffey, D.S The Effects of Immunosuppression on Sperm Granulomas in Vasectomized Rats. J. Urol. 112:793-797, 1974.

  214. Coffey, D.S The Effects of Androgens on DNA and RNA Synthesis in Sex Accessory Tissue. IN: Male Accessory Sex Organs (Brandes, D., Ed.), pp. 307-328, 1974.

  215. Berezney, R. and Coffey, D.S Identification of a Nuclear Protein Matrix. Biochem. Biophys. Res. Commun. 60:1410-1417, 1974.

  216. Brannen, G. E. and Coffey, D.S Immunologic Implications of Vasectomy: II. Serum-Mediated Immunity. Fertil. Steril. 25:515-520, 1974.

  217. Brannen, G. E., Kwart, A. M. and Coffey, D.S Immunologic Implications of Vasectomy: I. Cell-Mediated Immunity. Fertil. Steril. 25:508-514, 1974.

  218. Coffey, D.S, Barrack, E. R. and Heston, W. D. W. The Regulation of Nuclear DNA Template Restrictions by Acidic Polymers. IN: Advances in Enzyme Regulation (Weber, G., Ed.), Vol. 12, pp. 219-266, 1974.

  219. Freeman, C. and Coffey, D.S A New Method for Suppressing Sperm Granuloma Formation in the Vasectomized Rat. Fertil. Steril. 25:276-279, 1974.

  220. Sufrin, G. and Coffey, D.S A Comparison of the Hormone Responsiveness of the Prostate and Seminal Vesicles. Invest. Urol. 11:386-391, 1974.

  221. Freeman, C. and Coffey, D.S Male Sterility Induced by Ethanol Injection into the Vas Deferens. Int. J. Fertil. 18:129-132, 1973.

  222. Freeman, C. and Coffey, D.S Sterility in Male Animals Induced by Injection of Chemical Agents into the Vas Deferens. Fertil. Steril. 24:884-890, 1973.

  223. Kwart, A. M. and Coffey, D.S Sperm Granulomas: An Adverse Effect of Vasectomy. J. Urol. 110:416-422, 1973.

  224. Sufrin, G. and Coffey, D.S A New Model for Studying the Effect of Drugs on Prostatic Growth. I. Antiandrogens and DNA Synthesis. Invest. Urol. 11:45-54, 1973.

  225. Coffey, D.S, Barrack, E. R. and Heston, W. D. W. Brady Monograph. II. The Regulation of Nuclear DNA Template Restrictions by Acidic Polymers. Published by The James Buchanan Brady Urological Institute of The Johns Hopkins Hospital, December 1973.

  226. Brown, D. G. and Coffey, D.S Effect of Different Sizes of Polyacrylic Acid on the Structure and DNA Template Properties of Isolated Rat Liver Nuclei and Soluble Chromatin. Biochim. Biophys. Res. Commun. 294:74-86, 1973.

  227. Brown, D. G. and Coffey, D.S Release of Nuclear DNA Template Restrictions by Specific Polyribonucleotides. IN: Proceedings of the First International Conference on Cell Differentiation (Munksgaard, Copenhagen). Williams and Wilkins Co., Baltimore, Maryland, pp. 243-249, 1972.

  228. Mohr, S. J., Brown, D. G. and Coffey, D.S Size Requirement of Polyinosinic Acid for DNA Synthesis, Viral Resistance, and Increased Survival of Leukaemic Mice. Nature (New Biol.) 240:250-252, 1972.

  229. Arnold, E. A., Yawn, D. H., Brown, D. G., Wyllie, R. C. and Coffey, D. S. Structural Alteration in Isolated Rat Liver Nuclei After Removal of Template Restriction by Polyanions. J. Cell Biol. 53:737-757, 1972.

  230. Carter, M. F., Chung, L. W. K. and Coffey, D.S The Temporal Requirements for Androgens During the Cell Cycle of the Prostate Gland. IN: Urological Research (King, L. R. and Murphy, G. P., Eds.), Plenum Press, New York-London, pp. 27-38, 1972.

  231. Brown, D. G. and Coffey, D.S Effects of Polyinosinic Acid and Polycytidylic Acid on the Deoxyribonucleic Acid Template Activity of Isolated Nuclei and Soluble Chromatin from Rat Liver. J. Biol. Chem. 247:7674-7683, 1972.

  232. Chung, L. W. K. and Coffey, D.S Biochemical Characterization of Prostatic Nuclei. II. Relationship Between DNA Synthesis and Protein Synthesis. Biochim. Biophys. Res. Commun. 247:584-596, 1971.

  233. Chung, L. W. K. and Coffey, D.S Biochemical Characterization of Prostatic Nuclei. I. Androgen-Induced Changes in Nuclear Proteins. Biochim. Biophys. Res. Commun. 247:570-583, 1971.

  234. Brown, D. G. and Coffey, D.S The Release of Chromatin Template Restrictions by Natural Polyribonucleotides. Biochem. Biophys. Res. Commun. 42:326-333, 1971.

  235. Brown, D. G. and Coffey, D.S Release of Nuclear DNA Template Restrictions by Specific Polyribonucleotides. Science 171:176-178, 1971.

  236. Kraemer, R. J. and Coffey, D.S The Interaction of Natural and Synthetic Polyanions with Mammalian Nuclei. II. Nuclear Swelling. Biochim. Biophys. Acta 224:568-578, 1970.

  237. Kraemer, R. J. and Coffey, D.S The Interaction of Natural and Synthetic Polyanions with Mammalian Nuclei. I. DNA Synthesis. Biochim. Biophys. Acta 224:553-567, 1970.

  238. Brasel, J. A., Coffey, D.S and Williams-Ashman, H. G. Androgen- Induced Changes in the DNA Polymerase Activity of Coagulating Glands of Castrated Rats. Med. Exp. 18:321-326, 1969. v

  239. Texter, J. H. and Coffey, D.S The Effects of Amphotericin B on Prostatic and Testicular Function in the Dog. Invest. Urol. 7:90-106, 1969.

  240. Coffey, D.S, Ichinose, R. R., Shimazaki, J. and Williams-Ashman, H.G. Effects of Testosterone on Adenosine Triphosphate and Nicotinamide Adenine Dinucleotide Levels, and on Nicotinamide Mononucleotide Adenyltransferase Activity in the Ventral Prostate of Castrated Rats. Mol. Pharmacol. 4:580-590, 1968.

  241. Coffey, D.S, Shimazaki, J. and Williams-Ashman, H. G. Polymerization of Deoxyribonucleotides in Relation to Androgen-Induced Prostatic Growth. Arch. Biochem. Biophys. 124:184-198, 1968.

  242. Hellerman, L. and Coffey, D.S Studies on Crystalline D-Amino Acid Oxidase. V. Characterization of Borohydride-Reduced Enzyme-Substrate Intermediate. Synthesis of Note: The change to pitch (12) and font (4) must be converted manually.eNote: The change to pitch (12) and font (1) must be converted manually.-N-(1-Carboxymethyl)-L-Lysine. J. Biol. Chem. 242:582-589, 1967.

  243. Neims, A. H., Coffey, D.S and Hellerman, L. Interaction Between Tetraethylthiuram Disulfide and the Sulfhydryl Groups of D-Amino Acid Oxidase and of Hemoglobin. J. Biol. Chem. 241:5941-5948, 1966.

  244. Neims, A. H., Coffey, D.S and Hellerman, L. A Sensitive Radioassay for Sulfhydryl Groups with Tetraethylthiuram Disulfide. J. Biol. Chem. 241:3036, 1966.

  245. Coffey, D.S, Neims, A. H. and Hellerman, L. Studies on Crystalline D-Amino Acid Oxidase. II. Isolation of a Reduced 14C-Labeled Substrate-Enzyme Intermediate After the Action of Sodium Borohydride. J. Biol. Chem. 240:4058-4064, 1965.

  246. Coffey, D.S and Hellerman, L. The Interaction of 2,6-Dichloroindo- phenol and Protein Sulfhydryl Groups. Biochim. Biophys. Acta 100:98-103, 1965.

  247. Hellerman, L., Coffey, D.S and Neims, A. H. Studies on Crystalline D-Amino Acid Oxidase. I. Selective Inhibition in the Action of Sulfhydryl-Binding Reagents. J. Biol. Chem. 240:290-298, 1965.

  248. Coffey, D.S and Hellerman, L. Oxidation of Biological Thiols: Glutathione-Indophenol Interactions. Biochemistry 3:394-402, 1964.



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