David Sidransky, M.D.

Professor of Otolaryngology, Oncology, Pathology, Urology
Director, Head and Neck Cancer Research

Johns Hopkins Medical Institutions

Fax: Fax: (410) 614-1411


F Free Access to abstracts at PubMed


  1. Sidransky, D., Von Eschenbach, A., Tsai, Y.C., Jones, P., Summerhayes, I., Marshall, F., Paul, M., Green, P., Hamilton, S.R., Frost, P., Vogelstein, B. Identification of p53 Gene Mutations in Bladder Cancers and Urine Samples. Science 252(5006):706-709, 1991.

  2. Hollstein, M., Sidransky, D., Vogelstein, B., Harris, C. p53 Mutations in Human Cancer. Science 253(5015):49-53, 1991.

  3. Saylors, R.L., Sidransky, D., Friedman, H.S., Bigner, S.H., Bigner, D.D., Vogelstein, B., Brodeur, G. Infrequent p53 Gene Mutations in Medulloblastoma. Cancer Research 51(17):4721-4723, 1991.

  4. Kastan, M.B., Onyekwere, O., Sidransky, D., Vogelstein, B., Craig, R.W. Participation of p53 Protein in the Cellular Response to DNA Damage. Cancer Research 51(23 Pt 1):6304-6311, 1991.

  5. Sidransky, D., Mikkelsan, T., Cavenee, W., Vogelstein, B. Clonal Expansion of p53 Mutant Cells is Associated with Brain Tumour Progression. Nature 335(6363):846-847, 1992.

  6. Bennett, W.P., Hollstein, M.C., Hsu, I.C., Sidransky, D., Lane, D.P., Vogelstein, B., Harris, C.C. Mutational Spectra and Immunohistochemical Analyses of p53 in Human Cancers. Chest 101(3 Suppl):19S-20S, 1992.

  7. Sidransky, D., Frost, P., Von Eschenbach, A., Oyasu, R., Preisinger, A.C., Vogelstein, B. Clonal Origin of Bladder Cancer. N Engl J Med 326(11):737-740, 1992.

  8. Sidransky, D., Tokino, T., Frost, P., Hamilton, S., Levin, B., Vogelstein, B. Identification of Ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors. Science 256(5053):102-105, 1992.

  9. Sidransky, D., Tokino, T., Helzlsouer, K., et. al. Inherited p53 Gene Mutations in Breast Cancer. Cancer Research 52(10):2984-2986, 1992.

  10. Lynch, H.T., Watson, P., Smyrk, T.C., Lanspa, S.J., Boma, B.M., Boland, C.R., Lynch, J.F., Cavalieri, R.J., Leppert, M., White, R. Sidransky, D., Vogelstein, B. Colon Cancer Genetics. Cancer 70(S):1300-1312, 1992.

  11. Celano, P., Berchtold, C.M., Mabry, M., Carroll, M., Sidransky, D., Casero, R.A., Jr., Lupu, R. Induction of Markers of Normal Differentiation in Human Colon Carcinoma Cells by the v-rasH Oncogene. Cell Growth Differ 4(4):341-347, 1993.

  12. Leach, F.S., Tokino, T., Meltzer, P. Burrell, M., Oliner, J.D., Smith, S., Hill, D.E., Sidransky, D., Kinzler, K.W., Vogelstein, B. p53 Mutation and MDM2 Amplification in Human Soft Tissue Sarcomas. Cancer Research 53(10 Suppl):2231-2234, 1993.

  13. Boyle, J.O., Koch, W., Hruban, R.H., van der Reit, P., Sidransky, D. The Incidence of p53 Mutations Increases with Progression of Head and Neck Cancer. Cancer Research 53(19):4477-4480, 1993.

  14. Ruppert, J.M., Tokino, K. Sidransky, D. Evidence for Two Bladder Cancer Suppressor Loci on Human Chromosome 9. Cancer Research 53(21):5093-5095, 1993.

  15. Tokino, T., Davidson, N., Helzlsouer, K., Zhenbauer, B., Nakamura, Y., Vogelstein, B., Sidransky, D. Absence of Germline Prohibitin Mutations in Early Onset Breast Cancer. International Journal of Oncology 3(4):769-772, 1993.

  16. Gonzalez-Zulueta, M. Ruppert, J.M., Tokino, K., Tsai, Y.C., Spruck, C.H., III, Miyao, N., Nichols, P.W., Hermann, G.G., Horn, T., Steven, K., Summerhayes, I.C., Sidransky, D., Jones, P.W. Microsatellite Instability in Bladder Cancer. Cancer Research 53(23):5620-5623, 1993.

  17. van der Reit, P. Karp, D. Farmer, E. Wei, Q., Grossman, L., Tokino, K. Ruppert, J.M., Sidransky, D. Progression of Basal Cell Carcinoma Through Loss of Chromosome 9q and Inactivation of a Single p53 Allele. Cancer Research 54(1):25-27, 1994.

  18. Merlo, A. Gabrielson, E., Askin, F. A, Sidransky, D. Frequent Loss of Chromosome 9 in Human Primary Non-Small Cell Lung Cancer. Cancer Research 54(3):640-642, 1994.

  19. Mao, L., Sidransky, D. Tetranucleotide Repeat Polymorphism in RAF1. Hum Mol Gen 3(3):521, 1994.

  20. Nawroz, H. van der Reit, P., Hruban, R.H., Koch, W.M., Ruppert, J.M., Sidransky, D. Allelotype of Head and Neck Squamous Cell Carcinoma. Cancer Research 54(5):1152-1155, 1994.

  21. van der Reit, P., Nawroz, H., Hruban, R.H., Corio, R., Tokino, K., Koch, W.M., Sidransky, D. Frequent Loss of Chromosome 9p21-22 Early in Head and Neck Cancer Progression. Cancer Research 54(5):1156-1158, 1994.

  22. Cairns, P., Tokino, K., Eby, Y. Sidransky, D. Homozygous Deletions of 9p21 in Primary Human Bladder Tumors Detected by Comparative Multiplex Polymerase Chain Reaction. Cancer Research 54(6):1422-1424, 1994.

  23. Mao, L., Hruban, R.H., Boyle, J.O., Tockman, M. Sidransky, D. Detection of Oncogene Mutations in Sputum Precedes Diagnosis of Lung Cancer. Cancer Research 54(7):1634-1637, 1994.

  24. Merlo, A., Mabry, M., Gabrielson, E., Vollmer, R., Baylin, S.B., Sidransky, D. Frequent Microsatellite Instability in Primary Small Cell Lung Cancer. Cancer Research 54(8):2098-2101, 1994.

  25. Merlo, A., Gabrielson, E., Mabry, M., Vollmer, R., baylin, S.B., Sidransky, D. Homozygous Deletion on Chromosome 9p and Loss of Heterozygosity on 9q, 6p, and 6q in Primary Human Small Cell Lung Cancer. Cancer Research 54(9):2322-2326, 1994.

  26. Hruban, R.H., van der Reit, P., Erozan, Y.S., Sidransky, D. Brief Report: Molecular Biology and the Early Detection of Carcinoma of the Bladder - The Case of Hubert H. Humphrey. N Engl J Med 330(18):1276-1278, 1994.

  27. Thomas, S., Brennan, J., Martel, G., Frazer, I., Montesano, R., Sidransky, D., Hollstein, M. Mutations in the Conserved Regions of p53 are Infrequent in Betel-Associated Oral Cancers from Papua New Guinea. Cancer Research 54(13):3588-3593, 1994.

  28. Huang, D.P., Lo, K-W., van Hasselt, C.A., Woo, J.K.S., Choi, P.H.K., Leung, S-F., Cheung, S-T., Cairns, P., Sidransky, D., Lee, J.C.K. A Region of Homozygous Deletion on Chromosome 9p21-22 in Primary Nasopharyngeal Carcinoma. Cancer Research 54(15):4003-4006, 1994.

  29. Yoo, g.H., Xu, H-J., Brennan, J.A., Westra, W., Hruban, R.H., Koch, W.M., Benedict, W.F., Sidransky, D. Infrequent Inactivation of the Retinoblastoma Gene Despite Frequent Loss of Chromosome 13q in Head and Neck Squamous Cell Carcinoma. Cancer Research 54(17):4603-4606, 1994.

  30. Koch, W.M., Boyle, J.O., Mao, L., Hakim, J., Hruban, R.H., Sidransky, D. p53 Gene Mutations as Markers of Tumor Spread in Synchronous Oral Cancers. Arch Otolaryngol Head Neck Surg 120(9):943-947, 1994.

  31. Blaugrund, J.E., Johns, M.M., Jr., Eby, Y.J., Ball, D.W., Baylin, S.B., Hruban, R.H., Sidransky, D. Ret Proto-Oncogene Mutations in Inherited and Sporadic Medullary Thyroid Cancer. Hum Mol Genet 3(10):1895-1897, 1994.

  32. Mao, L., Lee, D.J., Tockman, M.S., Erozan, Y.S., Askin, F., Sidransky, D. Microsatellite Alterations As Clonal Markers in the Detection of Human Cancer. Proc Natl Acad Sci (USA) 91(21):9871-9875, 1994.

  33. Boyle, J.B., Mao, L., Brennan, J.A., Koch, W.M., Eisele, D.W., Saunders, J.R., Sidransky, D. Gene Mutations in Saliva as Molecular Markers for Head and Neck Squamous Cell Carcinomas. Am J Surg 168(5):429-432, 1994.

  34. Koch, W., Sidransky, D. p53 Mutational Spectra in Elderly Patients. Archives of Otolaryngology - Head and Neck Surgery 120:943-947, 1994.

  35. Schoenberg, M.Cairns, P., Brooks, J.D., Marshall, F.F., Epstein, J.I., Isaacs, W.B., Sidransky, D. Frequent Loss of Chromosome Arms 8p and 13q in Collecting Duct Carcinoma (CDC) of the Kidney. Genes Chromosomes Cancer 12(1):76-80, 1995.

  36. Bedi, G.C., Westra, W.H., Farzadegan, H., Pitha, P.M., Sidransky, D. Microsatellite Instability in Primary Neoplasms from HIV+ Patients. Nat Med 1(1):65-68, 1995.

  37. Cairns, P., Tokino, K., Eby, Y., Sidransky, D. Localization of Tumor Suppressor Loci on Chromosome 9 in Primary Human Renal Cell Carcinomas. Cancer Research 55(2):224-227, 1995.

  38. Brennan, J.A., Mao, L., Hruban, R.H., Boyle, J.O., Eby, Y.J., Koch, W.M., Goodman, S.N., Sidransky, D. Molecular Assessment of Histopathologic Staging in Squamous-Cell Carcinoma of the Head and Neck. N Engl J Med 332(7):429-435, 1995.

  39. Koch, W.M., Patel, H., Brennan, J., Boyle, J.O., Sidransky, D. Squamous Cell Carcinoma of the Head and Neck in the Elderly. Arch Otolaryngol Head Neck Surg 121(3):262-265, 1995.

  40. Rabkin, C.S., Bedi, G., Musaba, E., Sunkutu, R., Mwansa, N., Sidransky, D., Biggar, R.J. Aids-related Kaposi's Sarcoma is a Clonal Neoplasm. Clin Cancer Res 1(3):257-260, 1995.

  41. Brennan, J.A., Boyle, J.O., Koch, W.M., Goodman, S.N., Hruban, R.H., Eby, Y.J., Couch, M.J., Forastiere, A.A., Sidransky, D. Association Between Cigarette Smoking and Mutation of the p53 Gene in Squamous-Cell Carcinoma of the Head and Neck. N Engl J Med 332(11):712-717, 1995.

  42. Merlo, A., Herman, J.G., Mao, L., Lee, D.J., Gabrielson, E., Burger, P.C., Baylin, S.B., Sidransky, D. 5' CpG Island Methylation is Associated with Transcriptional Silencing f the Tumour Suppressor p16/CDKN2/MTS1 in Human Cancers. Nat Med 1(7):686-692, 1995.

  43. Mao, L., Merlo, A., Bedi, G., Shapiro, G.L., Edwards, C.D., Rollins, B.J., Sidransky, D. A Novel p16INK4A Transcript. Cancer Research 55(14):2995-2997, 1995.

  44. Chang, W.Y-H., Cairns, P., Schoenberg, M.P., Polasick, T.J., Sidransky, D. Novel Suppressor Loci on Chromosome 14q in Primary Bladder Cancer. Cancer Research 55(15):3246-3249, 1995.

  45. Bedi, A., Barber, J.P., Bedi, G.C., El-Deiry, W.S., Sidransky, D., Vala, M.S., Hilton, J., Akhtar, A.J., Jones, R.J. BCR-ABL-Mediated Inhibition of Apoptosis with Delay of G2/M Transition After DNA Damage: A Mechanism of Resistance to Multiple Anticancer Agents. Blood 86(3):1148-1158, 1995.

  46. Herman, J.G., Merlo, A., Mao, L., Lapidus, R.G., Issa, J-P.J., Davidson, N.E., Sidransky, D. Baylin, S.B. Inactivation of the CDKN2/p16/MTS1 Gene is Frequently Associated with Aberrant DNA Methylation in All Common Human Cancers. Cancer Research 55(20):4525-4530, 1995.

  47. Rosin, M.P., Cairns, P., Epstein, J.I., Schoenberg, M.P., Sidransky, D. Partial Allelotype of Carcinoma in situ of the Human Bladder. Cancer Research 55(22):5213-5216, 1995.

  48. Polasick, T.J., Cairns, P., Chang, W.Y-H., Schoenberg, M.P., Sidransky, D. Distinct Regions of Allelic Loss on Human Chromosome 4 in Primary Bladder Carcinoma. Cancer Research 55(22):5396-5399, 1995.

  49. Shapiro, G.I., Park, J.E., Edwards, C.D., Mao, L., Merlo, A., Sidransky, D., Ewen, M.E., Rollins, B.J. Multiple Mechanisms of p16INK4A Inactivation in Non-Small Cell Lung Cancer Cell Lines. Cancer Research 55(24):6200-6209, 1995.

  50. Cairns, P., Polascik, T.J., Eby, Y., Tokino, K. Califano, J., Merlo, A., Mao, L., Herath, J., Jenkins, R., Westra, W., Rutter, J.L., Buckler, A., Gabrielson, E., Tockman, M., Cho, K.R., Hedrick, L., Bova, G.S., Issacs, W., Schwab, D., Sidransky, D. Frequency of Homozygous Deletion at p16/CDKN2 in Primary Human Tumors. Nature Genetics 11(2):210-212, 1995.

  51. Gartenhaus, R., Johns, M.M., III, Wang, P., Rai, K., Sidransky, D. Mutator Phenotype in a Subset of Chronic Lymphocytic Leukemia. Blood 87(1):38-41, 1996.

  52. Mao, L., Schoenberg, M.P., Scicchitano, M., Erozan, Y.S., Merlo, A., Schwab, D., Sidransky, D. Molecular Detection of Primary Bladder Cancer by Microsatellite Analysis. Science 271(5249):659-662, 1996.

  53. Schoenberg, M., Kiemeney, L., Walsh, P.C., Griffin, C.A., Sidransky, D. Germline Translocation t(5-20)(p15-q11) and Familial Transitional Cell Carcinoma. J Urol 155(3):1035-1036, 1996.

  54. Johns, M., III, Westra, W.H., Califano, J.A., Eisele, D., Koch, W.M., Sidransky, D. Allelotype of Salivary Gland Tumors. Cancer Research 56(5):1151-1154, 1996.

  55. Fujii, H., Marsh, C., Cairns, P., Sidransky, D. Gabrielson, E. Genetic Divergence in the Clonal Evolution of Breast Cancer. Cancer Research 56(7):1493-1497, 1996.

  56. Polasick, T.J., Cairns, P., Epstein, J.I., Fuzesi, L., Ro, J.Y., Marshall, F.F., Sidransky, D. Distal Nephron Renal Tumors: Microsatellite Allelotype. Cancer Research 56(8):1892-1895, 1996.

  57. Bedi, G.C., Westra, W.H., Gabrielson, E., Koch, W., Sidransky, D. Multiple Head and Neck Tumors: Evidence for a Common Clonal Origin. Cancer Research 56(11):2484-2487, 1996.

  58. Califano, J., van der Reit, P., Westra, W., Nawroz, H., Clayman, G., Piantadosi, S., Corio, R., Lee, D., Greenberg, B., Koch, W. Sidransky, D. Genetic Progression Model for Head and Neck Cancer: Implications for Field Cancerization. Cancer Research 56(11):2488-2492, 1996.

  59. Schutte, M., Hruban, R.H., Hedrick, L., Cho, K.R., Nadasdy, G.M., Weinstein, C.L., Bova, G.S., Isaacs, W.B., Cairns, P., Nawroz, H., Sidransky, D. Casero, R.A., Jr., Meltzer, P.S., Hahn, S.A., Kern, S.E DPC4 Gene in Various Tumor Types. Cancer Research 56(11):2527-2530, 1996.

  60. Reed, A., Califano, J., Cairns, P., Westra, W.H., Jones, R., Koch, W., Ahrendt, S., Eby, Y., Swell, D., Nawroz, H., Bartek, J., Sidransky, D. High Frequency of p16 (CDKN2/MTS-1/INK4A) Inactivation in Head and Neck Squamous Cell Carcinoma. Cancer Research 56(16):3630-3633, 1996.

  61. Nawroz, H., Koch, W., Anker, P., Stroun, M., Sidransky, D. Microsatellite Alterations in Serum DNA of Head and Neck Cancer Patients. Nat Med 2(9):1035-1037, 1996.

  62. Liggett, W.H., Jr., Sewell, D.A., Rocco, J., Ahrendt, S.A., Koch, W., Sidransky, D. p16 and p16ß are Potent Growth Suppressors of Head and Neck Squamous Carcinoma Cells In Vitro. Cancer Research 56(18):4119-4123, 1996.

  63. Yao, S-L., Akhtar, A.J., McKenna, K.A., Bedi, G.C., Sidransky, D., Mabry, M., Ravi, R., Collector, M.I., Jones, R.J., Sharkis, S.J., Fuchs, E.J., Bedi, A. Selective Radiosensitization of p53-Deficient Cells by Caffeine-Mediated Activation of p34cdc2 Kinase. Nat Med 2(10):1140-1143, 1996.

  64. Steiner, G., Cairns, P., Polascik, T.J., Marshall, F.F., Epstein, J.I., Sidransky, D. Schoenberg, M.P. High-Density Mapping on Chromosomal Arm 1q in Renal Collecting Duct Carcinoma: Region of Minimal Deletion at 1q32.1-32.2. Cancer Research 56(21):5044-5046, 1996.

  65. Moskaluk, C.A., Heitmiller, R., Zahurak, M., Schwab, D., Sidransky, D., Hamilton, S.R. p53 and p21(WAF1/CIP1/SDI1) Gene Products in Barrett Esophagus and Adenocarcinoma of the Esophagus and Esophagogastric Junction. Human Pathol 27(11):1211-1220, 1996.

  66. Koch, W.M., Brennan, J.A., Zahurak, M., Goodman, S.N., Westra, W.H., Schwab, D., Yoo, G.H., Lee, D.J., Forastiere, A., Sidransky, D. p53 Mutation and Locoregional Treatment Failure in Head and Neck Squamous Cell Carcinoma. J Natl Cancer Inst 88(21):1580-1586, 1996.

  67. Califano, J.A., Ahrendt, S., Meininger, G., Koch, W., Westra, W.H., Sidransky, D. Detection of Telomerase Activity in Oral Rinses from Head and Neck Squamous Cell Cancer Patients. Cancer Research 56(24):5720-5722, 1996.

  68. Califano, J.A., Johns, M.M., III, Westra, W.H., Lango, M., Eisele, D., Saji, M., Zeiger, M.A., Udelsman, R., Koch, W.M., Sidransky, D. An Allelotype of Papillary Thyroid Cancer. Int J Cancer 69(6):442-444, 1996.

  69. Wiest, J.S., Franklin, W.A., Drabkin, H., Gemmill, R., Sidransky, D., Anderson, M.W. Genetic Markers for Early Detection of Lung Cancer and Outcome Measures for Response to Chemoprevention. J Cell Biochem Supp. 28-29:64-73, 1997.

  70. Wiest, J.S., Franklin, W.A., Otstot, J.T., Forbey, K., Varella-Garcia, M., Rao, K., Drabkin, H., Gemmill, R., Ahrendt, S., Sidransky, D., Saccomanno, G., Fountain, J.W., Anderson, M.W. Identification of a Novel Region of Homozygous Deletion on Chromosome 9p in Squamous Cell Carcinoma of the Lung: The Location of a Putative Tumor Supressor Gene. Cancer Research 57(1):1-6, 1997.

  71. Lee, D.J., Koch, W.M., Yoo, G., Lango, M., Reed, A. Califano, J., Brennan, J.A., Westra, W.H., Zahurak, M., Sidransky, D. Impact of Chromosome 14q Loss on Survival in Primary Head and Neck Squamous Cell Carcinoma. Clin Cancer Res 3(4):501-505, 1997.

  72. Jarrard, D.F., Bova, G.S., Ewing, C.M., Herman, J.G., Pin, S.S., Nguyen, S.H., Cairns, P., Sidransky, D., Baylin, S.B., Isaacs, W.B., Deletional, Mutational, and Methylation Analyses of p16/CDKN2/MTS1 in Primary and Metastatic Prostate Cancer. Genes Chromosomes and Cancer 19(2):90-96, 1997.

  73. Steiner, G., Schoenberg, M.P., Linn, J.F., Mao, L., Sidransky, D. Detection of Bladder Cancer Recurrence by Microsatellite Analysis of Urine. Nat Med 3(6):621-624, 1997.

  74. Evron, E., Cairns, P., Halachmi, N., Ahrendt, S.A., Reed, A.L., Aidransky, D. Normal Polymorphism in the Incomplete Trinucleotide Repeat of the Arginine-Rich Protein Gene. Cancer Research 57(14):2888-2889, 1997.

  75. Ahrendt, S.A., Yang, S.C., Wu, L., Westra, W.H., Jen, J., Califano, J.A., Sidransky, D. Comparison of Oncogene Mutation Detection and Telomerase Activity for the Molecular Staging of Non-Small Cell Lung Cancer. Clin Cancer Res 3(7):1207-1214, 1997.

  76. Wang, Y., Hung, S-C., Linn, J.F., Steiner, G., Sidransky, D., Glazer, A.N., Mathies, R.A. Microsatellite-Based Cancer Detection Using Capillary Array Electrophoresis and Energy-Transfer Fluorescent Primers. Electrophoresis 18(10):1742-1748, 1997.

  77. Wang, S.I., Puc, J., Li, J., Bruce, J.N., Cairns, P., Sidransky, D., Parsons, R. Somatic Mutations of PTEN in Glioblastoma Multiforme. Cancer Research 57(19):4183-4186, 1997.

  78. Arap, W., Knudson, E., Sewell, D.A., Sidransky, D., Wang, J.Y.J., Huang, H.J.S., Cavenee, W.K. Functional Analysis of Wild-Type and Malignant Glioma Derived CDKN2A-Beta Alleles: Evidence for an RB-Independent Growth Suppressive Pathway. Oncogene 15(17):2013-2020, 1997.

  79. Cairns, P., Okami, K., Halachmi, S., Halachmi, N., Esteller, M., Herman, J.G., Jen, J., Isaacs, W.B., Bova, G.S., Sidransky, D. Frequent Inactivation of PTEN/MMAC1 in Primary Prostate Cancer. Cancer Research 57(22):4997-5000, 1997.

  80. Cairns, P., Okami, K., King, P., Bonacum, J., Ahrendt, S., Wu, L., Jen, J., Sidransky, D. Genomic Organization and Mutation Analysis of Hel-N1 in Lung Cancer with Chromosome 9p21 Deletions. Cancer Research 57(23):5356-5359, 1997.

  81. Okami, K., Cairns, P., Westra, W.H., Linn, J.F., Ahrendt, S.A., Wu, L., Sidransky, D., Jen, J. Detailed Deletion Mapping at Chromosome 9p21 in Non-Small Cell Lung Cancer by Microsatellite Analysis and Fluorescence in situ Hybridization. Int J Cancer (Predictive Oncology) 74(6):588-592, 1997.

  82. Linn, J.F., Lango, M., Halachmi, S., Schoenberg, M.P., Sidransky, D. Microsatellite Analysis and Telomerase Activity in Archived Tissue and Urine Samples of Bladder Cancer Patients. Int J Cancer (Predictive Oncology) 74(6):625-629, 1997.

  83. Halachmi, S., Enger, C., Rosenthal, D., Sidransky, D., Schoenberg, M. Molecular Diagnosis and Staging of Bladder Cancer. Molecular Urology 1(4):309-314, 1997.

  84. Suzuki, H., Freije, D., Nusskern, D.R., Okami, K., Cairns, P., Sidransky, D., Isaacs, W.B., Bova, G.S. Interfocal Heterogeneity of PTEN/MMAC1 Gene Alterations in Multiple Metastatic Prostate Cancer Tissues. Cancer Research 58(2):204-209, 1998.

  85. Okami, K., Wu, L., Riggins, G., Cairns, P., Goggins, M., Evron, E., Halachmi, N., Ahrendt, S.A., Reed, A.L., Hilgers, W., Kern, S.E., Koch, W.M., Sidransky, D., Jen, J. Analysis of PTEN/MMAC1 Alterations in Aerodigestive Tract Tumors. Cancer Research 58(3):509-511, 1998.

  86. Cairns, J.P., Chiang, P-W., Ramamoorthy, S., Kurnit, D.M., Sidransky, D. A Comparison Between Microsatellite and Quantitative-PCR Analyses to Detect Frequent p16 Copy Number Changes in Primary Bladder Tumors. Clin Cancer Res 4(2):441-444, 1998.

  87. Hibi, K., Robinson, C.R., Booker, S., Wu, L., Hamilton, S.R., Sidransky, D., Jen, J. Molecular Detection of Genetic Alterations in the Serum of Colorectal Cancer Patients. Cancer Research 58(7):1405-1407, 1998.

  88. Trink, B., Pai, S.I., Spunt, S.L., Raman, V., Cairns, P., Jen, J., Gabrielson, E., Sukumar, S., Sidransky, D. Absence of TSG101 Transcript Abnormalities in Human Cancers. Oncogene 16(21):2815-2818, 1998.

  89. Cairns, P., Evron, E., Okami, K., Halachmi, N., Esteller, M., Herman, J.G., Bose, S., Wang, S.I., Parsons, R., Sidransky, D. Point Mutation and Homozygous Deletion of PTEN/MMAC1 in Primary Bladder Cancers. Oncogene 16(24):3215-3218, 1998.

  90. Trink, B., Okami, K., Wu, L., Sriuranpong, V., Jen, J., Sidransky, D. A New Human p53 Homologue. Nature Medicine 4(7):747-748, 1998.

  91. Leong, P.P., Rezai, B., Koch, W.M., Reed, A., Eisele, D., Lee, D.J., Sidransky, D., Jen, J., Westra, W.H. Distinguishing Second Primary Tumors from Lung Metastases in Patients with Head and Neck Squamous Cell Carcinoma. J Natl Cancer Inst 90(13):972-977, 1998.

  92. Nawroz-Danish, H.M.N., Koch, W.M., Westra, W.H., Sidransky, D. Lack of BRCA2 Alterations in Primary Head and Neck Squamous Cell Carcinoma. Otolaryngol Head Neck Surg 119(1):21-25, 1998.

  93. Rocco, J.W., Li, D., Liggett, W.H., Duan, L., Saunders, J.K., Jr., Sidransky, D., O'Malley, B.W., Jr. p16INK4A Adenovirus-Mediated Gene Therapy of Human Head and Neck Squamous Cell Cancer. Clin Cancer Res 4(7):1697-1704, 1998.

  94. Pai, S.I., Wu, G.S., Özören, N., Wu, L., Jen, J., Sidransky, D., El-Deiry, W.S. Rare Loss-of-Function Mutation of a Death Receptor Gene in Head and Neck Cancer. Cancer Research 58(16):3513-3518, 1998.

  95. Halachmi, N., Halachmi, S., Evron, E., Cairns, P., Okami, K., Saji, M., Westra, W.H., Zeiger, M.A., Jen, J., Sidransky, D. Somatic Mutations of the PTEN Tumor Suppressor Gene in Sporadic Follicular Thyroid Tumors. Genes Chromosomes Cancer 23(3):239-243, 1998.

  96. Boland, C.R., Thibodeau, S.N., Hamilton, S.R., Sidransky, D., Eshleman, J.R., Burt, R.W., Meltzer, S.J., Rodriguez-Bigas, M.A., Fodde, R., Ranzani, G.N., Srivastava, S. A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: Development of International Criteria for the Determination of Microsatellite Instability in Colorectal Cancer. Cancer Research 58(22):5248-5257, 1998.

  97. Baker, L.A., Chow, N.H., Docimo, S.G., Gearhart, J.P., Sidransky, D., Schoenberg, M.P. Microsatellite Deoxyribonucleic Acid Analysis to Detect Bladder Cancer in Bladder Exstrophy. J Urol 160(6 Pt 1):2192-2193, 1998.

  98. Sanchez-Cespedes, M., Cairns, P., Jen, J., Sidransky, D. Degenerate Oligonucleotide-Primed PCR (DOP-PCR): Evaluation of its Reliability for Screening of Genetic Alterations in Neoplasia. Biotechniques 25(6):1036-1038, 1998.

  99. Hibi, K., Liu, Q., Beaudry, G.A., Madden, S.L., Westra, W.H., Wehage, S.L., Yang, S.C., Heitmiller, R.F., Bertelsen, A.H., Sidransky, D., Jen, J. Serial Analysis of Gene Expression in Non-Small Cell Lung Cancer. Cancer Research 58(24):5690-5694, 1998.

  100. Westra, W.H., Koch, W.M., Sidransky, D., Jen, J. Distinguishing Second Primary Tumors From Lung Metastases in Patients with Head and Neck Squamous Cell Carcinoma - Response. JNCI 90(20):1571, 1998.

  101. Esteller, M., Sanchez-Cespedes, M., Rosell, R., Sidransky, D. Baylin, S.B., Herman, J.G. Detection of Aberrant Promoter Hypermethylation of Tumor Supressor Genes in Serum DNA from Non-Small Cell Lung Cancer Patients. Cancer Research 59(1):67-70, 1999.

  102. Ahrendt, S.A., Chow, Xu, L., Yang, S.C., Eisenberg, C.F., Esteller, M., Herman, J.G., Wu, L., Decker, P.A., Jen, J., Sidransky, D. Molecular Detection of Tumor Cells in Bronchoalveolar Lavage Fluid From Patients With Early Stage Lung Cancer. J Natl Cancer Inst 91(4):332-339, 1999.

  103. Merbs, S., Sidransky, D. Analysis of p16 (CDKN2/MTS-1/INK4A) Alterations in Primary Sporadic Uveal Melanoma. Invest Ophthalmol Vis Sci 40(3):779-783, 1999.

  104. Califano, J., Westra, W.H., Meininger, G., Reed, A., Koch, W., Sidransky, D. Unknown Primary Head and Neck Squamous Cell Carcinoma: Molecular Identification of the Site of Origin. J Natl Cancer Inst 91(7):599-604, 1999.

  105. Yamaguchi, K., Okami, K., Hibi, K., Wehage, S.L., Jen, J., Sidransky, D. Mutation Analysis of hBUB1 in Aneuploid HNSCC and Lung Cancer Cell Lines. Cancer Lett 139(2):183-187, 1999.

  106. Ahrendt, S.A., Eisenberger, C.F., Yip, L., Rashid, A., Chow, J.T., Pitt, H.A., Sidransky, D. Chromosome 9p21 Loss and p16 Inactivation in Primary Sclerosing Cholangitis-Associated Cholangiocarcinoma. J Surg Res 84(1):88-93, 1999.

  107. Okami, K., Reed, A.L., Cairns, P., Koch, W.M., Westra, W.H., Wehage, S., Jen, J., Sidransky, D. Cyclin D-1 Amplification is Independent of p16 Inactivation in Head and Neck Squamous Cell Carcinoma. Oncogene 18(23):3541-3545, 1999.

  108. Ahrendt, S.A., Halachmi, S., Chow, J.T., Wu, L., Halachmi, N., Yang, S.C., Wehage, S., Jen, J., Sidransky, D. Rapid p53 Sequence Analysis in Primary Lung Cancer Using an Oligonucleotide Probe Array. Proc Natl Acad Sci 96(13):7382-7387, 1999.

  109. Parrella, P., Sidransky, D., Merbs, S.L. Allelotype of Posterior Uveal Melanoma: Implications for a Bifurcated Tumor Progression Pathway. Cancer Research 59(13):3032-3037, 1999.

  110. Califano, J., Leong, P.L., Koch, W.M., Eisenberg, C.F., Sidransky, D., Westra, W.H. Second Esophageal Tumors in Patients with Head and Neck Squamous Cell Carcinoma: An Assessment of Clonal Relationships. Clin Cancer Res 5(7):1862-1867, 1999.

  111. Hibi, K., Westra, W.H., Borges, M., Goodman, S., Sidransky, D., Jen, J. PGP9.5 As a Candidate Tumor Marker for Non-Small-Cell Lung Cancer. Am J Pathol 155(3):711-715, 1999.

  112. Eisenberger, C.F., Wu, L., Nicol, T., Shah, S.I., Sidransky, D., Westra, W.H. Comparative Microsatellite Analysis in Discerning Origin of Disseminated Tumor: The Case of a Patient with Malignant Ascites and a History of Multiple Tumors. Human Pathology (Case Studies) 30(9):1111-1113, 1999.

  113. Sanchez-Cespedes, M., Esteller, M., Hibi, K., Cope, F.O., Westra, W.H., Piantadosi, S., Herman, J.G., Jen, J., Sidransky, D. Molecular Detection of Neoplastic Cells in Lymph Nodes of Metastatic Colorectal Cancer Patients Predicts Recurrence. Clin Cancer Res 5(9):2450-2454, 1999.

  114. Docimo, S.G., Chow, N.H., Steiner, G., Silver, R.I., Rodriguez, R., Kinsman, S., Sidransky, D., Schoenberg, M. Detection of Adenocarcinoma by Urinary Microsatellite Analysis After Augmentation Cystoplasty. Urology 54(3):561, 1999.

  115. Taylor, D., Koch, W.M., Zahurak, M., Shah, K., Sidransky, D., Westra, W.H. Immunohistochemical Detection of p53 Protein Accumulation in Head and Neck Cancer: Correlation with p53 Gene Alterations. Human Pathol 30(10):1221-1225, 1999.

  116. . Sanchez-Cespedes, M., Reed A.L., Buta, M., Wu, L., Westra, W.H., Herman, J.G., Yang, S.C., Jen, J., Sidransky, D. Inactivation of the INK4A/ARF Locus Frequently Coexists with TP53 Mutations in Non-Small Cell Lung Cancer. Oncogene 18(43):5843-5849, 1999.

  117. Koch, W.M., Lango, M., Sewell, D. Zahurak, M., Sidransky, D. Head and Neck Cancer in Nonsmokers: A Distinct Clinical and Molecular Entity. Laryngoscope 109(10):1544-1551, 1999.

  118. Eisenberger, C.F., Schoenberg, M., Enger, C., Hortopan, S., Shah, S., Chow, N-H., Marshall, F.F., Sidransky, D. Diagnosis of Renal Cancer By Molecular Urinalysis. J Natl Cancer Inst 91(23):2028-2032, 1999.

  119. Gabrielson, E., Sidransky, D. Absence of Intragenic Mismatch Mutations in Small Cell Lung Cancers with Microsatellite Instability. International Journal of Cancer 80:944-945, 1999.

  120. Nawroz-Danish, H.M., Koch, W.M., Westra, W.H., Yoo, G., Sidransky, D. Second Place - Resident Basic Science Award 1997 - Lack of BRCA2 Alterations in Primary Head and Neck Squamous Cell Carcinoma. Otolaryngology - Head & Neck Surgery 199(1):21-25, 1999.

  121. Leong, P.M., Kauffman, C.L., Moresi, J.M., Wu, L., Jeronimo, C., Sidransky, D., Miller, S.J. Basal Cell Carcinoma-Like Epidermal Changes Overlying Dermatofibromas Often Reveal Loss of Heterozygosity in the PTCH Gene. Journal of Investigative Dermatology 113(2):279-280, 1999.

  122. Califano, J, Koch, W., Sidransky, D., Westra, W.H. Inverted Sinonasal Papilloma: A Molecular Genetic Appraisal of its Putative Status as a Precursor to Squamous Cell Carcinoma. Am J Pathol 156(1):333-337, 2000.

  123. Lynch, H.T., McComb, R.D., Osborn, N.K., Wolpert, P.A., Lynch, J.F., Wszolek, Z.K., Sidransky, D., Steg, R.E. Predominance of Brain Tumors in an Extended Li-Fraument (SBLA) Kindred, Including a Case of Sturge-Weber Syndrome. Cancer 88(2):433-439, 2000.

  124. Califano, J., Westra, W.H., Meininger, G., Corio, R., Koch, W., Sidransky, D. Genetic Progression and Clonal Relationship of Recurrent Premalignant Head and Neck Lesions. Clinical Cancer Research 6(2):347-352, 2000.

  125. Sanchez-Cespedes, M., Esteller, M., Wu, L., Nawroz-Danish, H., Yoo, G.H., Koch, W., Jen, J., Herman, J.G., Sidransky, D. Gene Promoter Hypermethylation in Tumors and Serum of Head and Neck Cancer Patients. Cancer Research 60(4):892-895, 2000.

  126. Halachmi, S., DeMarzo, A.M., Chow, N., Halachmi, N., Smith, A.E., Linn, J.F., Nativ, O., Epstein J.I., Schoenberg, M.P., Sidransky, D. Genetic Alterations in Urinary Bladder Carcinosarcoma: Evidence of a Common Clonal Origin. Eur Urol 37(3):350-357, 2000.

  127. Sanchez-Cespedes, M., Okami, K., Cairns, P., Sidransky, D. Molecular Analysis of the Candidate Tumor Suppressor Gene ING1 in Human Head and Neck Tumors with 13q Deletions. Genes Chromosomes Cancer 27(3):319-322, 2000.

  128. Fliss, M.S., Usadel, H., Caballero, O.L., Wu, L., Buta, M., Eleff, S.M., Jen, J., Sidransky, D. Facile Detection of Homoplasmic Mitochondrial DNA Mutations in Primary Tumors and Bodily Fluids. Science 287(5460):2017-2019, 2000.

  129. Gillison, M.L., Koch, W.M., Capone, R.B., Spafford, M., Westra, W.H., Wu, L., Zahurak, M.L. Daniel, R.W., Viglione, M. Symer, D.E., Shah, K.V., Sidransky, D. Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers. J Natl Cancer Inst 92(9):709-720, 2000.

  130. Yamaguchi, K., Wu, L., Caballero, O.L., Hibi, K., Trink, B., Resto, V., Cairns, P., Okami, K., Koch, W.M., Sidransky, D., Jen, J. Frequent Gain of the p40/p51/p63 Gene Locus in Primary Head and Neck Squamous Cell Carcinoma. Int J Cancer 86:684-689, 2000.

  131. Esteller, M., Toyota, M., Sanchez-Cespedes, M., Capella, G., Peinado, M.A., Watkins, D.N., Issa, J-P.J., Sidransky, D., Baylin, S.B., Herman, J.G. Inactivation of the DNA Repair Gene 06-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation is Associated with G to A Mutations in K-ras in Colorectal Tumorigenesis. Cancer Research 60(9):2368-2371, 2000.

  132. Ahrendt, S.A., Decker, P.A., Doffek, K., Wang, B., Xu, L., Demeure, M.J., Jen, J., Sidransky, D. Microsatellite Instability at Selected Tetranucleotide Repeats is Associated with p53 Mutations in Non-Small Cell Lung Cancer. Cancer Research 60(9):2488-2491, 2000.

  133. Hibi, K., Trink, B., Patturajan, M., Westra, W.H., Caballero, O.L., Hill, D.E., Jen, J., Sidransky, D. AIS is an Oncogene Amplified in Squamous Cell Carcinoma. Proc. Nat'l. Acad. Sci. 97(10):5462-5467, 2000.

  134. Shah, S.I., Greenberg, B., Califano, J., Chow, J., Lee, D.J., Sewell, D.A., Reed, A., Lango, M., Koch, W., Sidransky, D. Two Distinct Regions of Loss on Chromosome 4q in Primary Head and Neck Squamous Cell Carcinoma. Archives of Otolaryngology - Head and Neck Surgery, in press.

  135. Xu, L., Chow, J., Bonacum, J., Eisenberger, C., Ahrendt, S., Spafford, M., Wu, L., Lee, S.M., Piantadosi, S., Sidransky, D., Jen, J. Instability of (AAAG)n Repeat Sequences in Upper Aerodigestive Tract Cancers. Submitted, 1999.

  136. Cairns, P., Esteller, M., Herman, J.G., Schoenberg, M., Jeronimo, C., Sanchez-Cespedes, M., Chow, N.-H., Grasso, M., Wu, L., Westra, W., Sidransky, D. Molecular Detection of Early Stage Prostate Cancer in Urine. Nature Medicine, Submitted, 1999.

  137. Medintz, I.L., Lee, C.-C.R., Sidransky, D. Loss of Heterozygosity Assay for Molecular Detection of Cancer Using Energy-Transfer Primers and Capillary Array Electrophoresis. Genome Research, Submitted, 1999.

  138. Resto, V., Caballero, O.L., Buta, M.R., Westra, W.H., Wu, L., Westendorf, J.M., Jen, J., Hieter, P., Sidransky, D. A Putative Oncogenic Role for MPP11 in Head and Neck Squamous Cell Carcinoma. Submitted, 1999.

  139. Ahrendt, S.A., Chow, J.T., Yang, S.C., Wu, L., Zhang, M..-J., Jen, J., Sidransky, D. Mutation of the p53 Gene is Associated with Alcohol Consumption and Cigarette Smoking in Non-Small Cell Lung Cancer. Submitted.

  1. Sidransky, D., Messing, E. Molecular Genetics and Biochemical Mechanisms in Bladder Cancer. Oncogenes, Tumor Suppressor Genes, and Growth Factors. Urol Clin North Am 19(4):629-639, 1992.

  2. Sidransky, D., Boyle, J.O., Koch, W., van der Reit, P. Oncogene Mutations as Intermediate Markers. J Cell Biochem Suppl 17F:184-187, 1993.

  3. Sidransky, D. Boyle, J.O., Koch, W. Molecular Screening: Prospects for a New Approach. Arch Otolaryngol Head Neck Surg 119(11):1187-1190, 1993.

  4. Bast, R., Fenoglio-Preiser, C.M., Ozer, H., Sidransky, D. Clinical Applications of Tumor Markers. Patient Care 27(6):61-85, Medical Economics Publishing, 1993.

  5. Sidransky, D. Gene Mutations Aid Cytologic Screening of Cancer. Clinical Chemistry 39(4):708-709, 1993.

  6. Erlich, H.A., Gorodezky, C., Saiki, R., Sidransky, D., Sninsky, J. Molecular Biology of Cancer, Virus and HLA Typing. Rev Invest Clin Suppl:59-61, 1994.

  7. Mao, L., Sidransky, D. Cancer Screening Based on Genetic Alterations in Human Tumors. Cancer Research 54(7Suppl S):S1939-S1940, 1994.

  8. Sidransky, D. Molecular Screening - How Long Can We Afford to Wait? J Natl Cancer Inst 86(13):955-956, 1994.

  9. Cairns, P., Mao, L., Merlo, A., Lee, D.J., Schwab, D., Eby, Y., Tokino, K., van der Reit, P., Blaugrund, J.E., Sidransky, D. Rates of p16 (MTS1) Mutations in Primary Tumors with 9p Loss. Science 265(5170):415-417, 1994.

  10. Sidransky, D. Identification of Gene Mutations in Cancer Screening. Molecular Markers of Early Cancer, eds. W. Ki Hong, M.D., Scott Lippman, M.D., James L., Mulshine, M.D., Sudhir Srivastava, Ph.D., Futura Publishing Corporation, 1994.

  11. Sidransky, D. Molecular Markers in Cancer Diagnosis. J Natl Cancer Inst 87:17-29, 1995.

  12. Sidransky, D. Molecular Markers in Cancer - Can We Make Better Predictions? Int J Cancer 64(1):1-2, 1995.

  13. Sidransky, D. Molecular Genetics of Head and Neck Cancer. Curr Opin Oncol 7:229-233, 1995.

  14. Sidransky, D. Screening for Clonal Genetic Alterations. Eur J Cancer 31A(7/8):1127-1129, Elsevier Science, Ltd., 1995.

  15. Sidransky, D. Importance of Chromosome 9p Loss in Human Lung Cancer. J Natl Cancer Inst 87(16):1201-1202, 1995.

  16. Sidransky, D. DNA in Neoplastic Disease Diagnosis. Molecular Biology and Biotechnology - A Comprehensive Desk Reference, edited by Robert A. Meyers, VCH Publishers, Inc., 224-228, 1995.

  17. Sidransky, D., Holstein, M. Clinical Implications of the p53 Gene. Annu Rev Med 47:285-301, 1996.

  18. Brennan, J.A., Sidransky, D. Molecular Staging of Head and Neck Squamous Carcinoma. Cancer Metastasis 15(1):3-10, 1996.

  19. Sidransky, D. Two Track But One Race? Cancer Genetics. Curr Biol 6(5):523-525, 1996.

  20. Rosin, M.P., Miller, S.J., Schwab, D., Westra, W.H., Sidransky, D. Molecular Analysis of Effectiveness of Moh's Surgical Technique. Lancet 347(9016):1692-1693, 1996.

  21. Sidransky, D. Advances in Cancer Detection. Sci Am 275(3):104-109, 1996.

  22. Sidransky, D. Is Human Patched the Gatekeeper of Common Skin Cancers? Nature Genetics 14(1):7-8, 1996.

  23. Steiner, G., Sidransky, D. Molecular Differential Diagnosis of Renal Carcinoma: From Microscopes to Microsatellites. Am J Pathol 149(6), American Society for Investigative Pathology 149(6):1791-1795, 1996.

  24. Sidransky, D. Early Molecular Detection of Cancer. Accomplishments in Cancer Research 1995, J.G. Fortner & P.A. Sharp, General Motors Cancer Research Foundation, 1996.

  25. Sidransky, D. Nucleic Acid-Based Methods for the Detection of Cancer. Science 278(5340):1054-1059, 1997.

  26. Sidransky, D. Molecular Biology of Head and Neck Tumors. Cancers: Principles and Practice of Oncology, Chapter 29.1, Vicent T. DeVita, Jr., Samuel Hellman, Steven A. Rosenberg, J.B. Lippincott Publishers, 1997.

  27. Sidransky, D. Molecular Detection of Lung Cancer. Lung Cancer 2nd Ed., Blackwell Science Publishers, 1997.

  28. Cairns, P.Liu, B.C.-S., Sidransky, D. Molecular Biology of Bladder Cancer. Principles and Practice of Genitourinary Oncology, Chapter 20, 223-230, eds. Derek Raghavan, Howard I. Scher, Steven A. Leibel, and Paul H. Lange, Lippincott-Ravan Publishers, 1997.

  29. Liggett, W.H., Jr., Sidransky, D. The Role of p16 Tumor Suppressor Gene in Cancer. J Clin Oncol 16(3):1197-1206, 1998.

  30. Westra, W.H., Sidransky, D. Phenotypic and Genotypic Disparity in Premalignant Lesions: Of Calm Water and Crocodiles. Journal of the National Cancer Institute 90(20):1500-1501, 1998.

  31. Anbazhagan, R., Merlo, A., Sidransky, D., Gabrielson, E. Absence of Intragenic Mismatch Mutations in Small Cell Lung Cancers with Microsatellite Instability. Int J Cancer 80(6):944-945, 1999.

  32. Cairns, P. and Sidransky, D. Molecular Methods for the Diagnosis of Cancer. Biochim Biophys Acta 1423(2):c11-c18, 1999.

  33. Leong, P.M., Kauffman, C.L., Moresi, J.M., Wu, L., Jeronimo, C., Sidransky, D., Miller, S.J. Basal Cell Carcinoma-Like Epidermal Changes Overlying Dermatofibromas Often Reveal Loss of Heterozygosity in the PTCH Gene. J Invest Dermatol 113(2):279-280, 1999.

  34. Ahrendt, S.A., Sidransky, D. The Potential of Molecular Screening. Surg Oncol Clin N Am 8(4):641-656, 1999.

  35. Califano, J., Sidransky, D. Molecular Biology of Head and Neck Cancer. Head and Neck Cancer: A Multidisciplinary Approach, Chapter 1, Lippincott-Raven Publishers, pp.3-10, 1999.

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