Danny Y Song, M.D.

Associate Professor of Urology and Oncology
Radiation Oncology and Molecular Radiation Sciences

The Johns Hopkins University School of Medicine
Sidney Kimmel Comprehensive Cancer Center 401 N Broadway, Suite 1440 Baltimore, Maryland 21231-1000

Appointments: (410) 502-5875

Email: dsong2@jhmi.edu

Dr. Daniel (Danny) Song is an Associate Professor of urology, oncology, and radiation oncology at the Johns Hopkins School of Medicine. He serves as the co-director of the Prostate Cancer Multidisciplinary Clinic at the Johns Hopkins School of Medicine and the Physician Advisor and Director of Faculty Affairs for the Department of Radiation Oncology and Molecular Radiation Sciences. His area of clinical expertise is in the management of genitourinary cancers, including cancers of the prostate, bladder and urinary tract, and testicular cancer.

Dr. Song's applies his expertise in the utilization of a variety of radiation modalities including external beam radiation, image-guided and intensity-modulated radiation, prostate brachytherapy (seed implants), and stereotactic body radiation therapy.

Dr. Song's research interests include the development and refinement of new imaging methods to improve radiation targeting, as well as innovative means of reducing potential side effects of radiation treatment.  His research efforts have been sponsored and funded by competitive grants from organizations such as the Department of Defense, the National Cancer Institute, and the American Cancer Society.

He is board-certified, and also a member of the examination committee for the American Board of Radiology, which administers the board certification process for radiation oncologists nationwide.   He serves on the editorial board of the International Journal of Radiation Oncology, Biology, and Physics, the premier research journal for radiation oncology, and on the scientific review committees for the American Society for Radiation Oncology (ASTRO) and American Brachytherapy Society.  He also participated in writing practice consensus guidelines on stereotactic body radiation therapy (TG-101) and image-guided robotic brachytherapy (TG-192) produced by the American Association of Physics in Medicine. 




B.A., Southern Adventist University, Chattanooga, TN

1996 M.D. Medical College of Georgia, Augusta, GA



Sinai Hospital of Baltimore, Internal Medicine, Baltimore, Maryland


Radiation Oncology, The Johns Hopkins Hospital, Baltimore, Maryland

2000-01 Chief Resident,
Radiation Oncology, The Johns Hopkins Hospital, Baltimore, Maryland

Licensure & Certifications

  •  2001-2011       Board certification in Radiation Oncology, American Board of Radiology

  •         -2005       Virginia Board of Medicine

  •         -2005       Maryland Board of Physicians

  •         -2006       Maryland Dept of Health and Mental Hygiene, Division of Drug Control

  •         -2007       Drug Enforcement Administration license


  Free Access to abstracts at PubMed

Peer reviewed publications

  1. Benedict SH, Yenice KM, Followill D, Galvin JM, Hinson W, Kavanagh B, Keall P, Lovelock M, Meeks S, Papiez L, Purdie T, Sadagopan R, Schell MC, Salter B, Schlesinger DJ, Shiu AS, Solberg T, Song DY, Stieber V, Timmerman R, Tomé WA, Verellen D, Wang L, Yin FF: Stereotactic body radiation therapy: the report of AAPM Task Group 101.  Med Phys. 2010;37:4078-101.
  2. Podder TK, Beaulieu L, Caldwell B, Cormack RA, Crass JB, Dicker AP, Fenster A, Fichtinger G, Meltsner MA, Moerland MA, Nath R, Rivard MJ, Salcudean T, Song DY, Thomadsen BR, Yu Y: AAPM and GEC-ESTRO guidelines for image-guided robotic brachytherapy: Report of Task Group 192.  Med Phys. 2014 Oct;41(10):101501. doi: 10.1118/1.4895013.
  3. Song DY, Kavanagh BD, Benedict SH, Schefter TA: Stereotactic body radiotherapy: rationale, techniques, optimization, and application of an emerging technology. Oncology. 2004;18:1419-1430.
  4. Song DY: The role of radiotherapy in the treatment of locally advanced prostate cancer. Community Oncol. 2006;3:759-764.
  5. Tran PT, Hales RK, Zeng J, Aziz K, Salih T, Gajula RP, Chettiar S, Gandhi N, Wild AT, Kumar R, Herman JM, Song DY, DeWeese TL: Tissue biomarkers for prostate cancer radiation therapy. Curr Mol Med. 2012;12:772-787.
  6. Pinkawa M, Schoth F, Bohmer D, Hatiboglu G, Sharabi A, Song D, Eble MJ: Current standards and future directions for prostate cancer radiation therapy.  Exp Rev Anticancer Ther. 2013;13:75-88
  7. DeWeese TL, Song DY: Radiation dose escalation as treatment for clinically-localized prostate  cancer: is more really better? JAMA. 2005;294:1274-1275.
  8. Song DY, DeWeese TL: Can PSA nadir predict prostate cancer outcomes following radiotherapy?  Nat Clin Pract Urol. 2006;3:464-465.
  9. Song DY, DeWeese TL: Defining the appropriate measure of success for adjuvant radiation following prostatectomy.  Nat Clin Pract Urol. 2007;4(8):416-417. Munn DH, Beall AC,
  10. Song DY, Wrenn RW, Throckmorton DC:  Activation-induced apoptosis in human macrophages: developmental regulation of a novel cell death pathway by macrophage colony-stimulating factor and interferon. J Exp Med. 1995;181(1):127-136.
  11. Song DY, Lawrie WT, Abrams RA, Kafonek DR, Bayless TM, Welsh JS, DeWeese TL:  Acute and late radiotherapy toxicity in patients with inflammatory bowel disease.  Int J Radiat Oncol Biol Phys. 2001;51(2):455-459.
  12. Song DY, Thompson TL, Ramakrishnan V, Harrison R, Bhavsar N, Onaodowan O, DeWeese TL: Salvage Radiotherapy for Rising or Persistent PSA after Radical Prostatectomy. Urology. 2002;60(2):281-287.
  13. Yu HH, Song DY, Tsai Y, Thompson T, Frassica DA, DeWeese TL: Perineural invasion affects biochemical recurrence-free survival in patients with prostate cancer treated with definitive external beam radiotherapy.  Urology. 2007;70(1):111-116.
  14. Stoianovici D, Song D, Petrisor D, Ursu D, Mazilu D, Muntener M, Schar M, Patriciu A: "MRI Stealth" Robot for Prostate Interventions. Minim Invasive Ther & Allied Technol. 2007;16(4):241-248.  PMC3106223
  15. Jain A, Deguet A, Iordachita I, Chintalapani G, Blevins J, Le Y, Armour E, Burdette C, Song D, Fichtinger G: Intra-operative 3D guidance in prostate brachytherapy using a non-isocentric C-arm.  Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2007;10(Pt 2):9-17.
  16. Fichtinger G, Fiene J, Kennedy CW, Kronreif G, Iordachita I, Song DY, Burdette EC, Kazanzides P: Robotic assistance for ultrasound guided prostate brachytherapy.  Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2007;10(Pt 1):119-127.
  17. Fichtinger G, Fiene J, Kennedy CW, Kronreif G, Iordachita I, Song DY, Burdette EC, Kazanzides P: Robotic assistance for ultrasound guided prostate brachytherapy.  Med Image Anal. 2008;12(5);535-545.
  18. Muntener M, Patriciu A, Petrisor D, Schar M, Ursu D, Song DY, Stoianovici D: Transperineal prostate intervention: robot for fully automated MR imaging – system description and proof of principle in a canine model. Radiology. 2008;247(2):543-549.  PMC3108451
  19. Lin SH, Sugar E, Teslow T, McNutt T, Saleh H, Song DY: Comparison of daily couch shifts using MVCT (TomoTherapy) and B-mode Ultrasound (BAT system) during prostate radiotherapy.  Technol Cancer Res Treat. 2008;7(4):279-285. PMC3634324
  20. Foroughi P, Song D, Chintalapani G, Taylor RH, Fichtinger G: Localization of pelvic anatomical coordinate system using US/Atlas registration for total hip replacement.  Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2008;11:871-879.
  21. Ford EC, Gaudette R, Myers L, Vanderver B, Engineer L, Zellars R, Song DY, Wong J, DeWeese TL: Evaluation of safety in a radiation oncology setting using failure mode and effects analysis.  Int J Radiat Oncol Biol Phys. 2009;74(3):852-858.  PMC3655406
  22. Lee J, Liu X, Jain AK, Song DY, Burdette EC, Prince JL, Fichtinger G: Prostate brachytherapy seed reconstruction with Gaussian blurring and optimal coverage cost. IEEE Trans Med Imaging. 2009;28:1955-1968.  PMC2790003
  23. Susil RC, McNutt T, DeWeese TL, Song DY: Effects of prostate-rectum separation on rectal dose from external beam radiation therapy.  Int J Radiat Oncol Biol Phys. 2010;76(4):1251-1258.  PMC3115781
  24. Fallavollita P, Karim-Aghaloo Z, Burdette EC, Song DY, Abolmaesumi P, Fichtinger G:  Registration between ultrasound and fluoroscopy or CT in prostate brachytherapy.  Med Phys. 2010;37:2749-2760.
  25. Lin J, Sinibaldi VJ, Carducci MA, Denmeade S, Song D, DeWeese T, Eisenberger MA: Phase I trial with a combination of docetaxel and (153)Sm-lexidronam in patients with castration-resistant metastatic prostate cancer. Urol Oncol. 2011;29:670-675.  PMC3483074
  26. Lee J, Labat C, Jain AK, Song DY, Burdette C, Fichtinger G, Prince JL: REDMAPS – Reduced-dimensionality matching for prostate brachytherapy seed reconstruction.  IEEE Trans Med Imaging. 2011;30:38-51.  PMC3072797
  27. Song DY, Burdette EC, Fiene J, Armour E, Kronreif G, Deguet A, Zhang Z, Iordachita I, Fichtinger G, Kazanzides P: Robotic needle guide for prostate brachytherapy: clinical testing of feasibility and performance.  Brachytherapy. 2011;10:57-63.  PMC3021094
  28. Song DY, Jain AK, Zhang Z, Deguet A, Le Y, Armour E, Burdette EC, Fichtinger G: Dynamic intraoperative dosimetry for prostate brachytherapy using a non-isocentric C-arm.  Brachytherapy. 2011;10:98-106.
  29. Fallavollita P, Burdette EC, Song DY, Abolmaesumi P, Fichtinger G: Technical note: unsupervised C-arm pose tracking with radiographic fiducial.  Med Phys. 2011;38:2241-2245.
  30. Lee J, Kuo N, Deguet A, Dehghan E, Song DY, Burdette EC, Prince JL: Intraoperative 3D reconstruction of prostate brachytherapy implants with automatic pose correction.  Phys Med Biol. 2011;56:5011-5027.  PMC3172706
  31. Kuo N, Deguet A, Song DY, Burdette EC, Prince JL, Lee J: Automatic segmentation of radiographic fiducial and seeds from fluoroscopic images in prostate brachytherapy.  Med Eng Phys. 2012;34:64-77.  PMC3209498
  32. Jain A, Deguet A, Iordachita I, Chintalapani G, Vikal S, Blevins J, Le Y, Armour E, Burdette C, Song D, Fichtinger G: Intra-operative 3D guidance and edema detection in prostate brachytherapy using a non-isocentric C-arm.  Med Image Anal. 2012;16:731-743.
  33. Qiu H, Herman J, Ahuja N, DeWeese T, Song DY: Neoadjuvant chemoradiation followed by interstitial prostate brachytherapy for synchronous prostate and rectal cancer.  Pract Radiat Oncol. 2012;4:e77-84.
  34. Wenzel J, Jones R, Klimmek R, Krumm S, Darrell L, Song D, Stearns V, Ford J: Cancer support and resource needs among African American older adults.  Clin J Oncol Nurs. 2012;16(4):372-377.
  35. Kuo N, Kang HJ, Song DY, Kang JU, Boctor EM: Real-time photoacoustic imaging of prostate brachytherapy seeds using a clinical ultrasound system.  J Biomed Opt. 2012;17(6):066005.
  36. Dehghan E, Lee J, Fallavollita P, Kuo N, Deguet A, Le Y, Burdette EC, Song DY, Prince JL, Fichtinger G: Ultrasound-fluoroscopy registration for prostate brachytherapy dosimetry. Med Image Anal. 2012;16(7):1347-1358.  PMC3448845
  37. Majewicz A, Marra S, van Vledder M, Ming D, Choti M, Song DY, Okamura A: Behavior of tip-steerable needles in ex vivo and in vivo tissue.  IEEE Trans Biomed Eng. 2012;59(10):2705-2715.  PMC3448818
  38. Yang Y, Ford EC, Wu B, Pinkawa M, van Triest B, Campbell P, Song DY, McNutt TR: An overlap-volume-histogram based method for rectal dose prediction and automated treatment planning in the external beam prostate radiotherapy following hydrogel injection. Med Phys. 2013;Jan;40(1):011709. doi: 10.1118/1.4769424.
  39. Song DY, Herfarth KK, Uhl M, Eble MJ, Pinkawa M, van Triest B, Kalisvaart R, Weber DC, Miralbell R, DeWeese TL, Ford EC: A multi-institutional clinical trial of rectal dose reduction via injected polyethylene-glycol hydrogel during IMRT for prostate cancer: Analysis of dosimetric outcomes. Int J Radiat Oncol Biol Phys. 2013;87(1):81-87. (Epub 2013 Feb 13)  PMC3737267
  40. Gandhi N, Wild AT, Chettiar ST, Aziz K, Kato Y, Gajula RP, Williams RD, Cades JA, Annadanam A, Song D, Zhang Y, Hales RK, Herman JM, Armour E, DeWeese TL, Schaeffer EM, Tran PT: Novel Hsp90 inhibitor NVP-AUY922 radiosensitizes prostate cancer cells.  Cancer Biol Ther. 2013;14(4):347-356. (Epub 2013 Jan 28)  PMC3667875
  41. Christodouleas JP, Tang S, Susil RC, McNutt TR, Song DY, Bekelman J, Deville C, Vapiwala N, DeWeese TL, Lu HM, Both S: The effect of anterior proton beams in the setting of a prostate-rectum spacer.  Med Dosim. 2013;38(3):315-319. (Epub 2013 Apr 8)
  42. Corn PG, Song DY, Heath E, Maier J, Meyn R, Kuban D, DePetrillo TA, Mathew P: Sunitinib plus androgen deprivation and radiation therapy for patients with localized high-risk prostate cancer: results from a multi-institutional phase I study.  Int J Radiat Oncol Biol Phys. 2013;86(3):540-545. PMC4103023.
  43. Kuo N, Dehghan E, Deguet A, Song DY, Prince JL, Lee J: A dynamic dosimetry system for prostate brachytherapy.  Proc SPIE. 2013;Mar 8;8671. doi: 10.1117/12.2008097.  PMC3877329
  44. Alcorn S, Walker AJ, Gandhi N, Narang A, Wild AT, Hales RK, Herman JM, Song DY, DeWeese TL, Antonarakis ES, Tran PT: Molecularly targeted agents as radiosensitizers in cancer therapy--focus on prostate cancer.  Int J Mol Sci. 2013;Jul 16;14(7):14800-14832. doi: 10.3390/ijms140714800.  PMC3742274
  45. Lediju Bell MA, Kuo N, Song DY,  Boctor EM: Short-lag spatial coherence beamforming of photoacoustic images for enhanced visualization of prostate brachytherapy seeds.  Biomed Opt Express. 2013;Sep 4;4(10):1964-1977. doi: 10.1364/BOE.4.001964.  PMC3799659
  46. Uhl M, Herfarth K, Eble MJ, Pinkawa M, van Triest B, Kalisvaart R, Weber DC, Miralbell R, Song DY, DeWeese TL: Absorbable hydrogel spacer use in men undergoing prostate cancer radiotherapy: 12 month toxicity and proctoscopy results of a prospective multicenter phase II trial.  Radiat Oncol. 2014;9:96.  PMC24758224
  47. Kuo N, Dehghan E, Deguet A, Mian OY, Le Y, Burdette EC, Fichtinger G, Prince JL, Song DY, Lee J: An image-guidance system for dynamic dose calculation in prostate brachytherapy using ultrasound and fluoroscopy.  Med Phys. 2014;41(9):091712. doi: 10.1118/1.4893761.
  48. Lediju Bell MA, Kuo NP, Song DY, et al: In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging. J Biomed Opt. 2014;19(12):126011. doi:10.1117/1.JBO.19.12.126011.
  49. Huynh-Le M, Zhang Z, Tran PT, DeWeese TL, Song DY:  Low interrater reliability in grading of rectal bleeding using National Cancer Institute Common Toxicity Criteria and Radiation Therapy Oncology Group toxicity scales: a survey of radiation oncologists. Int J Radiat Oncol Biol Phys. 2014;Dec 1;90(5):1076-1082. doi: 10.1016/j.ijrobp.2014.08.014. (Epub 2014 Oct 13).
  50. Lediju Bell MA, Guo X, Song DY, Boctor EM. Transurethral light delivery for prostate photoacoustic imaging. J Biomed Opt. 2015 Mar 1;20(3):36002. doi: 10.1117/1.JBO.20.3.036002.
  51. Sundi D, Cohen J, Cole A, Neuman B, Cooper J, Faisal F, Raben M, Song DY, Drake C, Netto G, Macura K, DeWeese T, Partin A, Bivalacqua T, Ross A, Schaeffer E: Establishment of a new prostate cancer multidisciplinary clinic.  Prostate. 2015 75(2):191-9. PMCID: PMC4270998.
  52. Kumar R, Le Y, DeWeese T, Song DY: Re-implantation following sub-optimal dosimetry in low-dose-rate prostate brachytherapy: technique for outpatient source insertion using local anesthesia. J Contemp Brachy (in press).
  53. DeWeese TL, Song DY: Current evidence for the role of combined androgen suppression and radiation in the treatment of adenocarcinoma of the prostate. Urology. 2000;55:169-174.
  54. Swartz MJ, Janson K, DeWeese TL, Song DY. Radiation therapy for prostate cancer: the role for dose escalation.  Compr Ther. 2007;33:216-222.
  55. Redmond K, Song DY: Thoracic irradiation in the elderly.  Thorac Surg Clin. 2009;19:391-400.
  56. Song DY: Oncology scan—rising stars, fading stars, and shooting stars: new trends in prostate cancer management. Int J Radiat Oncol Biol Phys. 2014;89(1):4-6.

  1. Song DY, Blomgren H:  "Body Stereotactic Radiotherapy for Lung Tumors" in Body Stereotactic Radiotherapy, Kavanagh and Timmerman, eds., Williams-Wilkins, 2004.

  2. Benedict S, Song DY: "High Precision Radiotherapy" in IMRT Handbook: Foundations & clinical applications, Bortfeld, Schmidt-Ullrich, and de Neve, eds., Springer-Verlag, 2004.

  3. Benedict S, Cardinale RM, and Song DY: "Application of IMRT to stereotactic radiosurgery", in Intensity Modulated Radiotherapy: A Clinical Perspective, Arno J. Mundt and John C. Roeske, eds., BC Decker Inc Publisher, Hamilton, Ontario, Canada, 2004.

  4. Song DY, and DeWeese TL: "Radiotherapy for the treatment of locally advanced and metastatic prostate cancer", in Prostate Cancer: Surgical Principles and Practice, Kirby, Partin, Feneley, and Parsons eds., Taylor and Francis, London, 2005.

  5. Song DY, Jabbour S, and DeWeese TL: "Emerging concepts in improving the therapeutic outcome of locally advanced prostate cancer using radiation therapy", in Prostate Cancer: Biology, genetics, and the new therapeutics, Chung, Isaacs, and Simon eds., Humana Press, NJ, 2006.

  6. Song DY, DeWeese TL: "Radiation Therapy", in Dr. Patrick Walsh's Guide to Surviving Prostate Cancer, Janet Worthington and Patrick C. Walsh, Warner Books, NY. (in press)

  7. Christodouleas J, Fox J, Song DY, DeWeese TL: "Radiation Therapy for Prostate Cancer", in Early Diagnosis of Cancer Series: Prostate Cancer, Su LM (Ed), Saunders Elsevier, Philadelphia, PA, 2009.

  8. Song DY: "Brachytherapy for Prostate Cancer", in Radiation Oncology: a Question-Based Review", Hristov B, Lin S, Christodouleas J (Eds), Lippincott Williams & Wilkins, Philadelphia, PA, 2010.

  9. Hales R, Song DY: "Radiation Therapy" in Johns Hopkins Patients' Guide to Lung Cancer, Klamerus J, Brahmer J, Ettinger D (Eds), Jones and Bartlett, Sudbury, MA.

  10. Sharabi A, Song DY: "Effects on rectal dose of injectable hydrogel spacer", in Innovative Radiotherapy Techniques for Prostate Cancer, Pinkawa M (Ed), UNI-MED Science (in press).

  11. Song DY.  Stereotactic body radiation therapy: rationale and clinical experience. In: UpToDate.com, Rose BD (Ed), UpToDate, Wellesley, MA, 2008-2013.

  12. Dehghan E, Kuo N, Deguet A, Le Y, Armour E, Burdette EC, Song DY, Fichtinger G, Prince JL, Lee J:  "Ultrasound-Fluoroscopy Registration for Intraoperative Dynamic Dosimetry in Prostate Brachytherapy", in Abdomen and Thoracic Imaging, El-Baz, Saba, and Suri eds., Springer, 2014.


Departmental Administrative Appointments

2005-present    Member, SKCCC MD Logix development oversight committee
2005-present    Member, Johns Hopkins Hospital Clinical Quality Improvement committee
2005-present    Member, SKCCC Clinical Research Review Committee
2005-present    Institutional principal investigator, Radiation Therapy Oncology Group

Professional Societies

1995-present    Alpha Omega Alpha Medical Honor Society
1997-present    American Society for Therapeutic Radiology and Oncology
2002-present    American College of Surgeons Oncology Group
2004-present    American Brachytherapy Society

Awards & Honors

2002 Faculty Teaching Award, VCU Department of Radiation Oncology
2002 Teacher of the Year Award, Association of Residents in Radiation Oncology
2010 Educator of the Year Award, Association of Residents in Radiation Oncology
2014 Director's Teaching Award, The Sidney Kimmel Comprehensive Cancer Center