Charles G. Drake, M.D., Ph.D. Assistant Professor, Oncology, Immunology and Urology Johns Hopkins Sidney Kimmel Comprehensive Cancer Center Email:cdrake@jhmi.edu

   PUBLICATIONS

Peer-Reviewed Original Research Publications
1. Wilkerson DK, Mezrich R, Drake C, Sebok D, Zatina MA:  Magnetic resonance imaging of acute occlusive intestinal ischemia.  J Vasc Surg 4:567-71, 1990.

2. Drake CG, Babcock SK, Palmer E, Kotzin BL: Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice. PNAS  91:4062-4066, 1994.

3. Rozzo SJ, Drake CG, Chiang BL, Gershwin ME, Kotzin BL: Evidence for polyclonal T cell activation in murine models of systemic lupus erythematosus.  J Immunol 153:1340-1351, 1994.

4. Drake CG, Rozzo SJ, Hirschfeld HF, Smarnworawong NP, Palmer E, Kotzin BL: Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner. J Immunol 154:2441-2447, 1995.

5. Drake CG, Rozzo SJ, Vyse TJ, Palmer E, Kotzin BL: Genetic contributions to lupus-like disease in (NZB x NZW)F1 mice. Immunol Rev 144:51-74, 1995.

6. Drake CG, Rozzo SJ, Vyse TJ, Palmer E, Kotzin BL: Absence of coding sequence polymorphism in the serum amyloid P component gene (Sap) in autoimmune New Zealand Black mice.  Mamm Genome 7:466-467, 1996.

7. Vyse TJ, Drake CG, Rozzo SJ, Roper ER, Izui S, Kotzin BL: Genetic evidence for the importance of gp70 immune complexes versus antinuclear antibodies in the development of lupus nephritis of New Zealand hybrid mice J Clin Invest 98:1762-1772, 1996.

8.  Rozzo, SJ, Vyse, TJ, Drake CG, Kotzin BL:  Effect of background on the contribution of NZB loci to autoimmune lupus nephritis.  PNAS 93: 15154-15158, 1996.

9.  Vyse TJ, Rozzo SJ, Drake CG, Izui S, Kotzin BL:  Control of multiple autoantibodies linked with a lupus nephritis susceptibility locus in New Zealand Black mice. J Immunol 158:5566-5574, 1997.

10. Vyse TJ, Drake CG, Rozzo SJ, Appel  VB, Mathis D, Benoist C, Izui S, Palmer E, Kotzin BL:  Contributions of Ea (z) and Eb (z) MHC genes to lupus susceptibility in New Zealand Mice. J Immunol 160:2757-2766, 1998.

11.  Huang CT, Huso DL, Lu Z, Wang T, Zhou G, Kennedy EP, Drake CG, Morgan DJ, Sherman LA, Higgins AD, Pardoll DM, Adler AJ:  CD4+ T cells pass through an effector phase during the process of in vivo tolerance induction.  J Immunol 170:3945-3953, 2003.

12.  Kowalski J, Drake CG, Schwartz R, Powell J:  Non-Parametric, hypothesis-based analysis of microarrays for comparison of several phenotypes.  Bioinformatics  20: 364-373, 2004.

13.  Doody AD, Kovalchin JT, Mihalyo MA, Hagymasi AT, Drake CG, Adler AJ:  Glycoprotein 96 Can Chaperone Both MHC Class I- and Class II- Restricted  Epitopes for In Vivo Presentation, but Selectively Primes CD8+ T Cell Effector Function.  J Immunol 172:5924-5930, 2004.
 
14.  Huang CT, Workman CJ, Flies D, Pan, X, Marson AL, Zhou, G, Hipkiss, E, Ravi S, Kowalski J, Levitsky HI, Workman CJ,  Powell JD, Pardoll DM, Drake CG, Vignali DAA:  Role of LAG-3 in Regulatory T Cells.  Immunity 21:503-513, 2004.

15.  Agrawal N, Bettegowda C,  Cheong I, Geschwind J, Drake CG, Hipkiss EL, Tatsumi M, Dang LH,  Diaz L,  Pomper M, Abusedera M,  Wahl RH, Kinzler KW, Zhou S, Huso DL, Vogelstein B:  Bacteriolytic therapy can generate a potent immune response against experimental tumor. PNAS 101:15172-15177, 2004.

16.  Drake CG, Higgins AD, Mihalyo MA, Huang CT, Kelleher E, Ravi S, Hipkiss EL, Kennedy EP, Long M, McGary PW, Coryell L, Nelson WG, Pardoll DM, Adler AJ:   Androgen-Ablation Mitigates Tolerance to a Prostate/Prostate-Cancer Restricted Antigen.  Cancer Cell  7:239-249, 2005.

17.  Hurchla MA, Sedy JR, Gavrielli M, Drake CG, Murphy TL, Murphy KM: B and T Lymphocyte Attenuator Exhibits Structural and Expression Polymorphisms and Is Highly Induced in Anergic CD4+ T Cells. J Immunol 174:3377-3385, 2005.

18.  Safford M, Collins, S, Lutz, M, Allen, A, Huang CT, Kowalski J, Blackford A, Horton M, Drake CG, Schwartz RH, Powell JD. Egr-2 and Egr-3 are negative regulators of T cell activation.  Nature Immunology 6:472-480, 2005.

19.  Zhou G, Drake CG, Levitsky H:  Amplification of Tumor-specific Regulatory T cells Following Therapeutic Cancer Vaccines.  Blood 107:628-636, 2006.

20.  Palapattu GS, Meeker A, Harris T, Collector MI, Sharkis SJ, DeMarzo AM, Warlick C, Drake CG, Nelson WG:  Epithelial Architectural Destruction is Necessary for Bone Marrow Derived Cell Contribution to Regenerating Prostate Epithelium.  J Urol  176:813-818, 2006.

21.  Litvinov IV, Vander Griend DJ, Antony L, Dalrymple S, De Marzo AM, Drake CG, Isaacs  JT: Androgen Receptor as a Licensing Factor for DNA Replication in Androgen Sensitive Prostate Cancer Cells. PNAS 103(41):15085-15090, 2006.

22.  Collins S, Wolfriam LA, Drake CG, Horton MR, Powell JD: Cutting Edge: TCR-Induced NAB2 Enhances T Cell Function by Coactivating IL-2 Transcription.  J Immunol 177:8301-8305, 2006.

23.  Goldberg MV, Maris CM, Hipkiss EL, Flies AS, Zhen LZ, Tuder RM, Grosso JF, Harris TJ, Getnet D, Whartenby KA, Brockstedt DG, Dubensky TW, Chen L, Pardoll DM, Drake CG.  Role of PD-1 and its Ligand B7-H1 in Early Fate Decisions of CD8 T Cells.  Blood 110:186-192, 2007.

24.  Harris TJ, Grosso JF, Yen HR, Xin H, Kortylewski M, Albesiano E, Hipkiss EL, Getnet G, Goldberg MV, Maris CH, Housseau F, Pardoll DM, Drake CG:  An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity, JI Cutting Edge 179:4318-4321, 2007.

25.  Grosso JF, Kelleher CC, Harris TJ, Maris CH, Hipkiss EL, Bruno TC, DeMarzo A, Anders R, Netto G, Getnet D, Goldberg MV, Pardoll DM, Drake CG:  LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems.  J Clin Invest 117:3383-3392, 2007.

26.  Zarek PE, Huang CT, Lutz ER, Kowalski J, Horton MR, Linden J, Drake CG, Powell JD:  A2A Receptor Signaling Promotes Peripheral Tolerance by Inducing T cell Anergy and the Generation of Adaptive Regulatory T cells.  Blood Oct 1; Epub ahead of print, 2007.




Published Symposium Presentations
1. Drake CG, Sebok D, Mezrich R:  Real time three dimensional display of MRI angiograms.   Society of Magnetic Resonance in Medicine Eighth Annual Meeting, 1989. 

2. Drake CG, Sebok D, Hirkaler GM, Cavallo G, Mezrich R:  Simultaneous imaging and recording of physiological data in the open chest rabbit infarct model.   Society of Magnetic Resonance in Medicine Eighth Annual Meeting, 1989.

3. Drake CG, Babcock S, Palmer E, Kotzin BL: The contribution of NZB genes to disease in (NZB x NZW)F1 mice.  Clinical Research.  42:5A, 1994.

4.  Vyse TJ, Drake CG, Izui S, Kotzin BL:  Mapping an NZB locus on chromosome 1 linked with lupus nephritis, autoantibody production and total IgG3 levels.  American College of Rheumatology National Scientific Meeting, 1996.

5.  Vyse TJ, Drake CG, Rozzo S, Izui S, Kotzin BL:  Genetic evidence for the importance of anti-gp70 versus antinuclear autoantibodies in murine lupus nephritis.  American College of Rheumatology National Scientific Meeting, 1996.

6.  Drake CG, Parsons D:  An unusual case of carcinoid presenting with right to left shunt.  American College of Physicians Annual Meeting, 1997.

7.  Drake CG, Huang CT, Adler AJ, Pardoll DM:  Absence of activation or tolerance in T-cells specific for a prostate restricted antigen.  Regulation of Immunity and Autoimmunity, 2001.

8.  Drake CG, Huang CT, Kennedy EP, Adler AJ, Pardoll DM:  Castration alters immunological ignorance to a prostate-restricted self-antigen.  Mechanisms of Immune Tolerance, 2002.

9.  Keller ET, Rowley DR, Tomlins SA, Drake CG, Kantoff PW, Pienta KJ, Montie JE, Carter HB, Hruszkewicz AM, Gomez J, Mohla S, Getzenberg RH:  Eleventh Prouts Neck Meeting on Prostate Cancer: emerging strategies in prostate cancer therapy.  Cancer Res 67:9613-9615, 2007