Urology at Hopkins has developed with a
"a heritage of excellence"
and continues
to aspire to excellence
1904
Simple Perineal Prostatectomy for Benign Disease
At a time when open simple prostatectomy had a 20-percent mortality, Hugh Hampton Young developed specialized instruments and perfected the perineal approach, reducing mortality to 2 percent.
1904
Radical Prostatectomy for the Cure of Cancer
Hugh Hampton Young. Based on observations from performing simple prostatectomies, Young realized that it was possible to remove the entire organ. This was the beginning of an era of surgical management that continues to the present.
1913
Transurethral Prostatectomy
Hugh Hampton Young's "punch" procedure was the first endoscopic surgical procedure for the treatment of benign prostatic enlargement and the precursor of the modern transurethral prostatectomy.
1917
Founding of the Journal of Urology
Hugh Hampton Young. The American Urological Association absorbed the Journal in 1921 and it became the AUA’s official scientific publication. For the next seven decades, all of the editors were Brady faculty or prior trainees: Hugh H. Young (1917–1945); J. A. Campbell Colston (1946–1965); Hugh J. Jewett (1966–1977); William W. Scott (1977–1983); Herbert Brendler (1983–1985); and John T. Grayhack (1985–1994).
1917
Interstitial Radiotherapy
Hugh Hampton Young was among the first to administer interstitial radiotherapy for the treatment of prostate and bladder cancer.
1929
Posterior Urethral Valves
Hugh Hampton Young was among the first to clinically recognize, name and classify posterior urethral valves in children.
1946
Clinical Staging of Bladder Cancer
Hugh J. Jewett developed the first clinical staging of bladder cancer, created the basis for our modern-day staging of bladder cancer and developed a prognostic model that could be easily shared among physicians and patients.
1948
Research as an Integral Part of the Brady Residency
William Wallace Scott pioneered the first mandatory year of research during the urology residency, revolutionizing academic urology by creating surgeon/scientists.
1975
Discovery of Nuclear Matrix Protein
Donald S. Coffey. Isolation and recognition of a substructure to the mammalian cell nucleus (the nuclear matrix) that organizes genome functions into discrete regions. Figure from JAMA; 2006;296(4):445-448
1977
Functional reconstruction for bladder exstrophy
Robert D. Jeffs’s surgical approach to treating bladder exstrophy revolutionized the field, where urinary diversion was the standard treatment. Johns Hopkins remains the worldwide leader in the treatment of bladder exstrophy.
1979
Anatomy and surgical technique for control of the dorsal vein complex
Patrick Craig Walsh. Before this discovery and change in surgical technique, radical retropubic prostatectomy was often associated with life-threatening hemorrhage. Based on these anatomic observations, a technique for ligation and division of the dorsal vein complex made it possible to perform surgery under direct vision, resulting in a safer, more complete cancer operation. Postoperative mortality fell from 2 percent to 0.2 percent.
1981
Discovery of the Cavernous Nerves
Patrick C. Walsh and Pieter J . Donker. Prior to this discovery, all men who underwent a radical prostatectomy were impotent. However, this study demonstrated the location of the cavernous nerves, which was previously unknown. Because the cavernous nerves were shown to be outside the prostate, this study provided the basis for a surgical technique for their preservation.
1982
First purposeful nerve-sparing radical retropubic prostatectomy
Patrick Craig Walsh. Based on recognition that the capsular arteries and veins of the prostate (neurovascular bundle) provided the intraoperative landmark for identification of the microscopic cavernous nerves, and characterization of the fascial coverings of the prostate, a surgical technique was described that preserved sexual function.
1984
Mapping of alpha-1 adrenoreceptors in the prostate
Herbert Lepor and Ellen Shapiro. The detection and characterization of adrenergic receptors in the prostate provided the foundation for a radically different approach to benign prostatic hyperplasia management, and served to engage techniques, experimental approaches, and expertise common in the neurosciences for urologic research.
1984
The first use of hypothermia and circulatory arrest for the excision of renal cell carcinoma tumor thrombus above the diaphragm and into the right atrium
Fray Francis Marshall. This pioneering procedure made it possible for the first time to remove these extensive tumors more safely and more completely.
1992
First proof that familial aggregation of prostate cancer had a genetic basis
This ushered in technologies and paradigms of molecular genetics to the prostate cancer field.
1992
Discriminating the Role of Nitric Oxide in Penile Erection
Arthur L Burnett identifies and documents nitric oxide as a physiologic mediator and neurotransmitter of erectile function.
1993
Preoperative Nomogram to Predict Pathologic Stage - The Partin Tables
Based on three findings – Gleason score, clinical stage, and PSA – this nomogram made it possible for the first time preoperatively to predict what the pathologic stage would be after the prostate had been removed, i.e. the probability of cure.
1994
Prediction of Insignificant Tumor
The first criteria to identify ideal candidates for expectant management.
1995
Laparoscopic live donor nephrectomy (LDN).
Developed by a transplant surgeon, Lloyd Ratner, and a Brady urologist, Louis Kavoussi. This new advance had a profound impact on the field of transplantation. Compared to the standard open surgical approach, LDN results in less postoperative surgical pain, a shorter hospital stay, and quicker recovery. Consequently, the availability of this less- invasive surgical technique enhanced the willingness of family and friends to donate.
Figure from the New England Journal of Medicine, 2012; 366,141-9.
2012
HOXB13 Mutation: first mutation responsible for increased risk of prostate cancer in families.
Campbell's Textbook of Urology
Patrick C. Walsh. Walsh was Editor-in-Chief from 1986-2002 (5th, 6th, 7th, and 8th editions), during which time it expanded to encompass four volumes and 4,000 pages, becoming the definitive Urology textbook in the world. In recognition for his efforts, the book was renamed Campbell-Walsh Urology. Alan Partin has been an editor since 2002.
21 January 2015
BRADY CENTENNIAL
The Brady Urological Institute, given through the generosity of the James Buchanan Brady,

opened January 21,1915
IMAGE GALLERY
1897-1941
Hugh H. Young
Young performed the first perineal prostatectomy at the Johns Hopkins Hospital, 1927. IMAGE GALLERY
1946-1974
William W. Scott
During his tenure, Scott gave 15 named lectures and participated in some 25 visiting professorships. IMAGE GALLERY
1974-2004
Patrick C. Walsh
Dr. Walsh is best known for "the anatomic approach to radical prostatectomy". IMAGE GALLERY
2004-Present
Alan W. Partin
Dr. Partin is best known for developing The Partin Tables IMAGE GALLERY

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1905

Conservative Perineal Prostatectomy

The Early Diagnosis and Radical Cure of Carcinome of the Prostate

1913

A New Procedure (PUNCH OPERATION) for small prostatic bars and contracture of the prostatic orifice

1917

The use of radium and the punch operation in desperate cases of enlarged prostate

1918

The employment of the high frequency current for the extraction of calculi incarcerated in the lower end of the ureter

1919

A new germicide for use in the genito-urinary tract: "mercurochrome-220"

1920

Observations on gun-shot wounds of the urethra

1921

Physiological and pharmacological studies of the prostate gland

1922

An operation for the cure of incontinence associated with espispadias

1924

Secondary closure of tuberculous nephrectomy wounds

1925

Presentation of preoperative skin desinfectant - an alcohol- acetone-aqueous solution of mercurochrome

1926

Deep roentgen-ray therapy in the treatment of carcinoma of the bladder

1928

Vas ligation for the prevention of preoperative and post-operative epididymitis

1930

Medical Aspects of the treatment of benign prostatic hypertrophy

1931

A radical operation for the cure of cancer of the penis

1932

Carcinoma of the prostate, a clinical and pathological study

1934

Radiation Therapy of renal cortical neoplasms

1935

Bladder abnormalities due to injury of motor pathways in the nervous system

1937

The use of sulfanilamide in gonococcic infections

1938

Hypertension in unilateral renal disease

1939

Clinical experiments with androgens

1940

Stenosis of the ureteropelvic juncture: congenital and acquired

1941

Postoperative venous thrombosis and pulmonary embolism

1943

Carcinoma of the prostate

1947

Endocrine therapy in carcinoma of the prostate

1948

A new concept in the treatment of peynorie's diseases

1950

Prostatic cancer

1952

Infiltrating carcinoma of the bladder

1954

Renal homotransplantation: I The effect of cortisone on the transplant; II The effect of the transplant on the host

1955

Operation for tumor of a solitary kidney

1956

Significance of the palpable prostatic nodule

1957

Steroid response to therapy in prostatic cancer

1959

Radical Prostatectomy for early cancer

1961

Functional charactersitics of renovascular hypertension

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Under Construction

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James Buchanan Brady Urological Institute

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Based on a work at http://urology.jhu.edu/centennial