Bladder Cancer Research Center
Exploring New Treatments for Bladder Cancer
"THE p53 TRIAL"
This is an important study designed to provide better understanding of bladder cancer and how to treat patients with this disease. This trial is funded by the National Cancer Institute, and will enroll more than 500 patients in about three years from over 30 hospitals around the world.
Background information: Like all tumors, the development of bladder cancer occurs through various mechanisms, which usually involve a change in one of your genes. Genes are like blueprints for our bodies. They contain information that determines our appearance and many aspects of our health. Chromosomes are the packages of genes found in our cells. Like all cancers, bladder cancer develops when alterations of the genes accumulate over time. The most common gene alteration found in tumors occurs in a gene called "p53". The p53 gene is located on chromosome number 17 (see figure 1). The normal function of the p53 gene is to prevent the development of tumor growth, and that is why when the p53 gene is altered, the chance of developing a tumor increases.