- Histone Deacetylase Inhibitors Up-Regulate Expression Of The Coxsackie Adenovirus Receptor (CAR) Preferentially In Bladder Cancer Cells. Sachs, M., Ramamurthy, M., van der Poel, H., Wickham, T., Lamfers, M., Gerritsen, W., Chowdhury, W., Li, Y., Schoenberg, M., and Rodriguez, R.
We have discovered that a certain class of drugs (Histone Deacetylase Inhibitors) can cause bladder cancer cells to express a receptor which is commonly lost during its transition to an invasive malignancy. This finding has profound ramifications for gene therapy of bladder cancer, and may have implications for a potential strategy for chemoprevention of invasiveness. |
